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Why are neonates at higher risk for drug toxicity related to hepatic and
renal immaturity?
A) CYP450 enzymes are hyperactive at birth
B) Glomerular filtration rate and phase I/II liver enzymes are
significantly reduced
C) Plasma albumin levels are abnormally high
D) Biliary excretion is accelerated -ANSWER-B) Glomerular filtration
rate and phase I/II liver enzymes are significantly reduced
What physiological change in geriatric patients primarily contributes to
decreased drug clearance and prolonged half-life?
A) Increased cardiac output
B) Decreased glomerular filtration rate (GFR) and renal blood flow
C) Increased hepatic enzyme activity
D) Decreased body fat percentage -ANSWER-B) Decreased glomerular
filtration rate (GFR) and renal blood flow
How does increased body fat and decreased lean muscle mass in older
adults affect lipid-soluble (lipophilic) drugs?
,A)Increases their volume of distribution, leading to prolonged drug
accumulation and half-life
B)Decreases their volume of distribution and shortens half-life
C) Prevents them from crossing cellular membranes
D) Eliminates the need for hepatic metabolism -ANSWER-A) Increases
their volume of distribution, leading to prolonged drug accumulation
and half-life
What is the clinical consequence of decreased serum albumin in elderly
patients?
A) Decreased free (active) drug levels in plasma
B)Faster renal elimination
C)Increased free (active) fraction of highly protein-bound drugs, raising
toxicity risk
D) Reduced oral bioavailability –ANSWER-C)Increased free (active)
fraction of highly protein-bound drugs, raising toxicity risk
What is polypharmacy?
A) The use of a single drug to treat multiple conditions
B) The concurrent use of multiple medications by a patient, often
increasing the risk of interactions
C) The practice of compounding generic medications
D) The administration of drugs exclusively via intravenous infusion -
ANSWER-B) The concurrent use of multiple medications by a patient,
often increasing the risk of interactions
, What is the primary purpose of the Beers Criteria in geriatric
pharmacology?
A) To calculate drug dosages based on weight
B)To determine insurance reimbursement rates for prescription drugs
C) To regulate pharmaceutical manufacturing standards
D)To identify potentially inappropriate medications that should be
avoided in older adults -ANSWER-D) To identify potentially
inappropriate medications that should be avoided in older adults
During which stage of pregnancy is fetal exposure to teratogenic drugs
most likely to result in major structural malformations (organogenesis)?
A) First trimester
B) Second trimester
C) Third trimester
D) Labor and delivery -ANSWER-A) First trimester
Which maternal pharmacokinetic change during the third trimester of
pregnancy can significantly lower plasma concentrations of renally
cleared drugs?
A) Decreased cardiac output
B) Increased glomerular filtration rate (GFR) and renal plasma flow
C) Reduced total body water