GALEN COLLEGE OF NURSING
DEPARTMENT OF HUMAN SCIENCES — NU-110 INTEGRATED HUMAN SCIENCES
2026/27 EXAMINATION 1 — COMPREHENSIVE STUDY EXAM & ANSWER KEY
Student Name: ___________________________ Date:
Course/Section: NU-110 Integrated Human Score / Total: ________ / 100 Marks
Sciences
EXAMINATION INSTRUCTIONS & STRUCTURE:
1. This exam consists of 50 high-yield multiple-choice questions covering Units 1, 2, and 3.
2. Select the single best answer (A, B, C, or D) for each item.
4. All questions, options, and rationales are strictly grounded in Galen College of Nursing NU-110 curriculum
sources.
Question 1. Which chemical entity acts as the primary homeostatic regulator stimulating the
respiratory control center in the medulla oblongata to adjust pulmonary ventilation?
(A) Venous bicarbonate ion concentration
(B) Serum sodium level
(C) Arterial oxygen concentration (PaO2)
(D) Arterial carbon dioxide level (PaCO2)
✔ Correct Answer: Option (D) — Arterial carbon dioxide level (PaCO2)
Rationale: Carbon dioxide (CO2) is the primary chemical regulator of respiration. Chemoreceptors in the
brain stem and blood vessels detect changes in arterial CO2 levels, sending signals to the respiratory
control center in the medulla oblongata to adjust breathing rate and depth to maintain normal acid-base
homeostasis.
Question 2. A patient experiencing an acute panic attack presents with severe hyperventilation.
Which systemic arterial blood gas and pH alteration directly results from hypocapnia?
(A) Increased exhalation of carbon dioxide leading to alkalosis
(B) Decreased blood pH accompanied by elevated carbonic acid
(C) Retention of hydrogen ions leading to metabolic acidosis
(D) Decreased exhalation of carbon dioxide leading to respiratory acidosis
✔ Correct Answer: Option (A) — Increased exhalation of carbon dioxide leading to alkalosis
Rationale: Hyperventilation increases the rate and depth of breathing above optimal metabolic needs,
causing excessive exhalation of carbon dioxide (hypocapnia). This depletion of arterial CO2 decreases
carbonic acid concentration, causing systemic blood pH to rise (alkalosis).
Fall 2026 Examination 1 — Page 1 of 15
, Galen College of Nursing | NU-110 Integrated Human Sciences
Question 3. Hypoventilation causes insufficient movement of air into and out of the alveoli. What
immediate chemical shift occurs in the blood stream as a result of hypoventilation?
(A) Blood CO2 levels increase, causing respiratory acidosis
(B) Blood CO2 levels decrease, causing alkalosis
(C) Blood pH rises rapidly due to loss of hydrogen ions
(D) Bicarbonate ions are completely eliminated by the lungs
✔ Correct Answer: Option (A) — Blood CO2 levels increase, causing respiratory acidosis
Rationale: Hypoventilation occurs when pulmonary ventilation is inadequate to meet metabolic needs.
Carbon dioxide accumulates in the alveoli and bloodstream, forming carbonic acid and increasing hydrogen
ion concentration, which lowers blood pH and produces respiratory acidosis.
Question 4. In the chemical pathway of carbon dioxide transport, which enzyme catalyzes the
reversible conversion of carbon dioxide and water into carbonic acid within red blood cells?
(A) Creatine kinase
(B) Acetylcholinesterase
(C) Carbonic anhydrase
(D) Lactate dehydrogenase
✔ Correct Answer: Option (C) — Carbonic anhydrase
Rationale: Carbonic anhydrase is the enzyme inside erythrocytes that rapidly converts dissolved carbon
dioxide and water into carbonic acid (H2CO3), facilitating CO2 transport from metabolic tissues to the lungs.
Question 5. Following the enzymatic formation of carbonic acid (H2CO3) in systemic capillaries, into
which two ions does carbonic acid immediately dissociate?
(A) Calcium ions and phosphate ions
(B) Potassium ions and hydroxyl ions
(C) Sodium ions and chloride ions
(D) Hydrogen ions and bicarbonate ions
✔ Correct Answer: Option (D) — Hydrogen ions and bicarbonate ions
Rationale: Carbonic acid spontaneously separates into hydrogen ions (H+) and bicarbonate ions (HCO3-).
Bicarbonate diffuses into the plasma as the principal buffer carrying CO2 back to the lungs for elimination.
Question 6. Anatomically, the laryngopharynx serves as a shared conduit for air, liquids, and solids.
Into which anterior and posterior structures does the laryngopharynx open?
(A) Anteriorly into the oropharynx and posteriorly into the bronchi
(B) Anteriorly into the nasopharynx and posteriorly into the trachea
(C) Anteriorly into the larynx and posteriorly into the esophagus
(D) Anteriorly into the esophagus and posteriorly into the glottis
✔ Correct Answer: Option (C) — Anteriorly into the larynx and posteriorly into the esophagus
Rationale: The laryngopharynx is the inferior portion of the pharynx that branches anteriorly into the larynx
(voice box) to conduct air into the trachea, and posteriorly into the esophagus to direct food and liquids into
Fall 2026 Examination 1 — Page 2 of 15