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Advanced Pathophysiology- UTMB
5355 Exam 2|Certified Q&A 2026
histamine binding to H1 causes- answer-smooth muscle contraction
histamine binding to H2 causes- answer-smooth muscle relaxation, avoids
anaphylaxis
H2 blocker examples- answer-pepcid
H1 is- answer-pro-inflammatory
H2 is- answer-antiinflammatory
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Type 2 hypersensitivity is- answer-tissue specific; a specific cell or tissue is the
target of an immune response
Symptoms of many type II reactions are- answer-determined by the tissue or
organ being targeted.
In type 2 hypersensitivity reactions antibodies bind to- answer-tissue specific
antigens
IgG and IgM and complement cascade are active in- answer-type 2 reactions to
destroy cell membrane and initiate lysis of cell
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Examples of type 2 hypersensitivity reactions- answer-Autoimmune hemolytic
anemia or transfusion reactions (RBCs are destroyed by complement mediated
lysis)
Type 3 hypersensitivity is- answer-immune-complex mediated; antigen-antibody
complex not formed immune complexes form in the circulation and later are
deposited to vessels walls
Type III reactions are not - specific- answer-organ
cell damage in type III reactions are due to- answer-complement activation,
chemotaxis generated for neutrophils and lysosomal enzymes once in tissues
Examples of type III reactions include- answer-repeated IV administration of
drugs, lupus, glomerulonephritis, think generalized symptoms with rash
Advanced Pathophysiology- UTMB
5355 Exam 2|Certified Q&A 2026
histamine binding to H1 causes- answer-smooth muscle contraction
histamine binding to H2 causes- answer-smooth muscle relaxation, avoids
anaphylaxis
H2 blocker examples- answer-pepcid
H1 is- answer-pro-inflammatory
H2 is- answer-antiinflammatory
,2|Page
Type 2 hypersensitivity is- answer-tissue specific; a specific cell or tissue is the
target of an immune response
Symptoms of many type II reactions are- answer-determined by the tissue or
organ being targeted.
In type 2 hypersensitivity reactions antibodies bind to- answer-tissue specific
antigens
IgG and IgM and complement cascade are active in- answer-type 2 reactions to
destroy cell membrane and initiate lysis of cell
, 3|Page
Examples of type 2 hypersensitivity reactions- answer-Autoimmune hemolytic
anemia or transfusion reactions (RBCs are destroyed by complement mediated
lysis)
Type 3 hypersensitivity is- answer-immune-complex mediated; antigen-antibody
complex not formed immune complexes form in the circulation and later are
deposited to vessels walls
Type III reactions are not - specific- answer-organ
cell damage in type III reactions are due to- answer-complement activation,
chemotaxis generated for neutrophils and lysosomal enzymes once in tissues
Examples of type III reactions include- answer-repeated IV administration of
drugs, lupus, glomerulonephritis, think generalized symptoms with rash
