Sepsis | UPDATED Questions with 100% Verified Answers
Q1: What is the definition of sepsis? (book lab values)
A: fever>101.3
tachypnea>20
tachy > 90BPM
leukocytosis >12,000 cell/mm^3 or >10% immature or <4,000 cells/mm^3
*caused by an invasive infection
(15)
Q2: What organisms can cause sepsis?
A: MC in the past: gram () bacilli (ex e coli and klebesiella) and pseudomonas aeruginosa
Recently: more gram (+) and opportunistic fungi
(15)
Q3: According to our speaker what is sepsis? (words)
A: lifethreatening organ dysfunction due to dysregulated host response to infection
(speaker)
Q4: What is septic shock? (speaker book definition)
A: subset of sepsis in which underlying circulatory and cellular metabolism abnormalities
are profound enough to substantially increase mortality
(speaker)
Q5: What is our immune system responding to in sepsis that causes the development of septic shock?
A: We react to the endotoxins (LPS outer membrane of gram () bacteria binds tolllike
receptor)
(15)
Q6: What part of our immune system is responsible for causing septic shock?
A: innate immune system...
macrophages
neutrophils
dendritic cells
NK cells
mast cells
eosinophils
basophils
(15)
, Q7: What does LPS signaling ultimately cause?
A: outpouring of inflammatory cytokines and mediators
Through CD14, MD2, TLR4, and MyD88 or TRIF gross
(15)
Q8: What parts of the bacteria cause the problems in sepsis?
A: endotoxin
bacterial superantigens
peptidoglycan from cell wall of bacteria
capsular antigens from bacteria
lipoteichoic acid lipopeptides
microbial DNA
microbial toxins
procoagulant substances from bugs
(15)
Q9: What has the ability to activate large numbers of CD4+ cells by binding directly to class II antigens and
release inflammatory junk?
A: bacterial superantigens
(15)
Q10: What are the major inflammatory cytokines that play a role in sepsis?
A: TNFalpha
IL1B
(15)
Q11: What is the resulting injury caused by the release of cytokines (mainly TNF alpha and IL1B)?
A: endothelial injury
coagulation activation
and septic shock
(16)
Q12: Do you want Th1 or Th2 to predominate in sepsis?
A: 2, it moves the immune response to humoral and reduces inflammatory response
(16)
Q13: What interleukins promote the Th1 response? Th2?
A: IL12
IL2
Th2: IL4, IL10, IL13
(16)
Q1: What is the definition of sepsis? (book lab values)
A: fever>101.3
tachypnea>20
tachy > 90BPM
leukocytosis >12,000 cell/mm^3 or >10% immature or <4,000 cells/mm^3
*caused by an invasive infection
(15)
Q2: What organisms can cause sepsis?
A: MC in the past: gram () bacilli (ex e coli and klebesiella) and pseudomonas aeruginosa
Recently: more gram (+) and opportunistic fungi
(15)
Q3: According to our speaker what is sepsis? (words)
A: lifethreatening organ dysfunction due to dysregulated host response to infection
(speaker)
Q4: What is septic shock? (speaker book definition)
A: subset of sepsis in which underlying circulatory and cellular metabolism abnormalities
are profound enough to substantially increase mortality
(speaker)
Q5: What is our immune system responding to in sepsis that causes the development of septic shock?
A: We react to the endotoxins (LPS outer membrane of gram () bacteria binds tolllike
receptor)
(15)
Q6: What part of our immune system is responsible for causing septic shock?
A: innate immune system...
macrophages
neutrophils
dendritic cells
NK cells
mast cells
eosinophils
basophils
(15)
, Q7: What does LPS signaling ultimately cause?
A: outpouring of inflammatory cytokines and mediators
Through CD14, MD2, TLR4, and MyD88 or TRIF gross
(15)
Q8: What parts of the bacteria cause the problems in sepsis?
A: endotoxin
bacterial superantigens
peptidoglycan from cell wall of bacteria
capsular antigens from bacteria
lipoteichoic acid lipopeptides
microbial DNA
microbial toxins
procoagulant substances from bugs
(15)
Q9: What has the ability to activate large numbers of CD4+ cells by binding directly to class II antigens and
release inflammatory junk?
A: bacterial superantigens
(15)
Q10: What are the major inflammatory cytokines that play a role in sepsis?
A: TNFalpha
IL1B
(15)
Q11: What is the resulting injury caused by the release of cytokines (mainly TNF alpha and IL1B)?
A: endothelial injury
coagulation activation
and septic shock
(16)
Q12: Do you want Th1 or Th2 to predominate in sepsis?
A: 2, it moves the immune response to humoral and reduces inflammatory response
(16)
Q13: What interleukins promote the Th1 response? Th2?
A: IL12
IL2
Th2: IL4, IL10, IL13
(16)
