AAMC FL 1 FULL REVIEW – BIO/BIOCHEM |ACTUAL
QUESTIONS AND VERIFIED ANSWERS|BRAND NEW
2026-2027 UPDATE|GRADED A+
Question 1
Based on the data presented in the passage, which statement best describes the
HSP110ΔE9 allele?
A.Cancer-promoting and dominant to HSP110WT
B.Cancer-promoting and recessive to HSP110WT
C.Cancer-suppressing and dominant to HSP110WT
D.Cancer-suppressing and recessive to HSP110WT
CORRECT ANSWER
Cross out A and B. LOOK AT THE FIGURE! Tumor volume is DOWN.
Table 2 shows that HSP110ΔE9 allele when mixed with HSP110WT there is more
apoptotic cells. So it's dominant.
SLOW THE HECK DOWN AND READ
Question 2
Based on the passage, in MSI CRC primary tumor cells, the size of the deletion in the
HSP110 T17 microsatellite is inversely correlated with:
A.the amount of HSP110ΔE9 protein expressed.
1
,B.the number of mature HSP110WT transcripts synthesized.
C.the frequency of the omission of HSP110 Exon 9 during splicing.
D.the extent of premature translation termination in Exon 10.
CORRECT ANSWER
INVERSELY CORRELATED WITH
According to Table 1, as the size of the deletion increases, the amount of HSP110ΔE9 and
HSP110WT transcripts synthesized increase and decrease, respectively.
also: The larger HSP110 T17 deletions cause Exon 9 to be omitted from the final sequence
during pre-mRNA processing. This generates a premature stop codon in Exon 10,
resulting in the mutant protein HSP110ΔE9.
You're going to have MORE PRE-MATURE transcripts, SO LESS mature ones.
Question 3
A man with a CRC mutation that results in the synthesis of HSP110ΔE9 and a woman that
does not carry this mutation in any of her tissues have a child. What is the percent chance
that the child will inherit the CRC mutation?
A.0%
B.25%
C.50%
D.100%
passage: People with MSI CRC have HSP110ΔE9 transcripts in cancerous tissue only.
2
,CORRECT ANSWER
YOU AINT GONNA PASS DOWN CANCEROUS TISSUE
A!
Question 4
Which nucleotide pairing(s) would be recognized by the MMR system during DNA
replication?
dTMP and dCMP
dGMP and dAMP
dAMP and dTMP
A.I only
B.III only
C.I and II only
D.I, II, and III
CORRECT ANSWER
Looking for mismatched bases!
Roman numeral 2 comes up twice so start there.
G and A are not paired correctly (cross out a and b)
Now looking at 3. Adenine and Thymine are paired together normally, eliminate D, end
with C.
3
, Question 5
The information in the passage best supports the conclusion that Intron 8 of HSP110 most
likely contains which of the following?
A.Stop codon
B.Splice acceptor site
C.HSP110 gene promoter
D.Partial coding sequence of HSP110
CORRECT ANSWER
Introns are useless pieces of shit
only think it will have is a place for the splice some to come and crunch it.
Question 6
According to the information in the passage, HSP110 is most likely which type of protein?
A.Adhesion
B.Chaperone
C.Clathrin
D.Enzyme
Passage: HSP110 can bind structurally similar heat shock proteins and functions to facilitate
proper protein folding and to reduce levels of nonfunctional protein aggregates.
CORRECT ANSWER
FACILITATING PROTEIN FOLDING = CHAPERONE
4
QUESTIONS AND VERIFIED ANSWERS|BRAND NEW
2026-2027 UPDATE|GRADED A+
Question 1
Based on the data presented in the passage, which statement best describes the
HSP110ΔE9 allele?
A.Cancer-promoting and dominant to HSP110WT
B.Cancer-promoting and recessive to HSP110WT
C.Cancer-suppressing and dominant to HSP110WT
D.Cancer-suppressing and recessive to HSP110WT
CORRECT ANSWER
Cross out A and B. LOOK AT THE FIGURE! Tumor volume is DOWN.
Table 2 shows that HSP110ΔE9 allele when mixed with HSP110WT there is more
apoptotic cells. So it's dominant.
SLOW THE HECK DOWN AND READ
Question 2
Based on the passage, in MSI CRC primary tumor cells, the size of the deletion in the
HSP110 T17 microsatellite is inversely correlated with:
A.the amount of HSP110ΔE9 protein expressed.
1
,B.the number of mature HSP110WT transcripts synthesized.
C.the frequency of the omission of HSP110 Exon 9 during splicing.
D.the extent of premature translation termination in Exon 10.
CORRECT ANSWER
INVERSELY CORRELATED WITH
According to Table 1, as the size of the deletion increases, the amount of HSP110ΔE9 and
HSP110WT transcripts synthesized increase and decrease, respectively.
also: The larger HSP110 T17 deletions cause Exon 9 to be omitted from the final sequence
during pre-mRNA processing. This generates a premature stop codon in Exon 10,
resulting in the mutant protein HSP110ΔE9.
You're going to have MORE PRE-MATURE transcripts, SO LESS mature ones.
Question 3
A man with a CRC mutation that results in the synthesis of HSP110ΔE9 and a woman that
does not carry this mutation in any of her tissues have a child. What is the percent chance
that the child will inherit the CRC mutation?
A.0%
B.25%
C.50%
D.100%
passage: People with MSI CRC have HSP110ΔE9 transcripts in cancerous tissue only.
2
,CORRECT ANSWER
YOU AINT GONNA PASS DOWN CANCEROUS TISSUE
A!
Question 4
Which nucleotide pairing(s) would be recognized by the MMR system during DNA
replication?
dTMP and dCMP
dGMP and dAMP
dAMP and dTMP
A.I only
B.III only
C.I and II only
D.I, II, and III
CORRECT ANSWER
Looking for mismatched bases!
Roman numeral 2 comes up twice so start there.
G and A are not paired correctly (cross out a and b)
Now looking at 3. Adenine and Thymine are paired together normally, eliminate D, end
with C.
3
, Question 5
The information in the passage best supports the conclusion that Intron 8 of HSP110 most
likely contains which of the following?
A.Stop codon
B.Splice acceptor site
C.HSP110 gene promoter
D.Partial coding sequence of HSP110
CORRECT ANSWER
Introns are useless pieces of shit
only think it will have is a place for the splice some to come and crunch it.
Question 6
According to the information in the passage, HSP110 is most likely which type of protein?
A.Adhesion
B.Chaperone
C.Clathrin
D.Enzyme
Passage: HSP110 can bind structurally similar heat shock proteins and functions to facilitate
proper protein folding and to reduce levels of nonfunctional protein aggregates.
CORRECT ANSWER
FACILITATING PROTEIN FOLDING = CHAPERONE
4
