NSG 533 Opioid Quiz | UPDATED Questions with 100% Verified
Answers
Wilkes University • NSG 533
Q1: Endogenous opioid peptides
A: Small molecules that are naturally produced in the CNS and in various glands throughout
the body, such as the pituitary and adrenal glands. Consists of endorphins, enkephalins,
dynorphins, and nociceptins.
Q2: Mechanism of action for opioids
A: Stimulating opioid ureceptors in the CNS. Pure agonists (morphine) bind to ureceptors
to produce analgesia that increases with dose without a ceiling effect. Partial agonists at
the ureceptor (Buprenorphine, tramadol) cause less conformational change and
receptor activation than full agonists.
Q3: Indications for initiating opioid therapy
A: Used when benefits outweigh risks associated with opioids such as abuse. Used for acute
pain (including postsurgical) from under a month, and chronic pain.
Q4: Tolerance
A: the diminishing effect with regular use of the same dose of a drug, requiring the user to
take larger and larger doses before experiencing the drug's effect
Q5: Dependence
A: the condition that results when the brain develops a chemical need for a drug and cannot
function normally without it
Q6: Addiction
A: A physiological or psychological dependence on a drug
Q7: Neuralgia
A: nerve pain
Q8: Analgesia
A: Pain relief; inability to feel pain
Answers
Wilkes University • NSG 533
Q1: Endogenous opioid peptides
A: Small molecules that are naturally produced in the CNS and in various glands throughout
the body, such as the pituitary and adrenal glands. Consists of endorphins, enkephalins,
dynorphins, and nociceptins.
Q2: Mechanism of action for opioids
A: Stimulating opioid ureceptors in the CNS. Pure agonists (morphine) bind to ureceptors
to produce analgesia that increases with dose without a ceiling effect. Partial agonists at
the ureceptor (Buprenorphine, tramadol) cause less conformational change and
receptor activation than full agonists.
Q3: Indications for initiating opioid therapy
A: Used when benefits outweigh risks associated with opioids such as abuse. Used for acute
pain (including postsurgical) from under a month, and chronic pain.
Q4: Tolerance
A: the diminishing effect with regular use of the same dose of a drug, requiring the user to
take larger and larger doses before experiencing the drug's effect
Q5: Dependence
A: the condition that results when the brain develops a chemical need for a drug and cannot
function normally without it
Q6: Addiction
A: A physiological or psychological dependence on a drug
Q7: Neuralgia
A: nerve pain
Q8: Analgesia
A: Pain relief; inability to feel pain
