MEDICAL LABORATORY REVIEW:
IMMUNOHEMATOLOGY EXAM
What type of serological testing does the blood bank technologist perform when
determining the blood group of a patient? - Correct Answers -Phenotyping
If anti-K reacts 3+ with a donor cell with a genotype KK and 2+ with a Kk cell, the
antibody is demonstrating: - Correct Answers -Dosage
Carla expresses the blood group antigens FyA, FyB, and XgA. James shoes
expressions of none of these antigens. What factor may account for the absence of
these antigens in James? - Correct Answers -Gender
Which of the following statements is true? - Correct Answers -An individual with the BB
genotype is homozygous for B antigen
Which genotype will give rise to the Bombay phenotype? - Correct Answers -hh only
Meiosis in cell division is limited to the ova and sperm producing four gametes
containing what complement of DNA? - Correct Answers -1N
A cell that is not actively dividing is said to be in : - Correct Answers -Interphase
Which of the following describes the expression of most blood group antigens? - Correct
Answers -Codominant
What blood type is not possible for an offspring of AO and BO mating? - Correct
Answers -All are possible
The alleged father of a child in a disputed case of paternity is blood group AB. The
mother and child are group O. What type of exclusion is this? - Correct Answers -
Indirect/secondary/second order
If the frequency of gene Y is 0.4 and the frequency of gene Z is 0.5, one would expect
that they should occur together 0.2 (20%) of the time. In actuality, they are found
together 32% of the time. This is an example of: - Correct Answers -Linkage
disequilibrium
In the Hardy-Weinberg formula, p2 represents... - Correct Answers -The homozygous
population of one allele
, In this type of inheritance, the father carries the trait on his X chromosome. The has no
sons with the trait because he passed his y chromosome to them; however, all his
daughters will express the trait. - Correct Answers -X-linked dominant
Why do IgM antibodies, such as those formed against the ABO antigens, have the
ability to directly agglutinate red blood cells and cause visible agglutination? - Correct
Answers -IgM antibodies are larger molecule and have the ability to bind more antigen
Which of the following enhancement mediums decreases the zeta potential, allowing
antibody and antigen to come closer together? - Correct Answers -LISS
This type of antibody response is analogous to an anamnestic antibody reaction. -
Correct Answers -Secondary
Which antibodies to a component of complement are contained in the rabbit polyspecific
antihuman globulin reagent for detection of in vitro sensitization? - Correct Answers -
Anit-IgG and anti-C3d
Which distinguishes A1 from A@ blood groups? - Correct Answers -An A2 person may
form anti-A1; and A1 person will not for anti-A1
A patient's serum is incompatible with O cells. The patient RBCs give a negative
reaction to anti-H lectin. What is the most likely cause of these results? - Correct
Answers -The patient may be a Bombay
What antibodies are formed by a Bombay individual? - Correct Answers -Anti-A, B, and
H
Acquired B antigens have been found in - Correct Answers -Group A persons
Blood is crossmatched on an A pos person with a negative antibody screen, The patient
received a transfusion of A positive RBCs 3 years agao. The donors chosen for
crossmatch were A positive. The crossmatch was run on the Ortho Provue and yielded
3+ incompatibility. How can these results be explained? - Correct Answers -The patient
has an A2 with anti A1
A patient's red cells forward as group O, serum agglutinates B cells (4+) only. Your next
step would be: - Correct Answers -Incubate washed red cells with anti-A1 and anti-A, B
for 30 minutes at RT
Which typing results are most likely to occur when a patient has an acquired B antigen?
- Correct Answers -Anti-A 4+, anti-B 1+, A1 cells neg, B cells 4+
What sample is best for detecting complement-dependent antibodies? - Correct
Answers -Serum stored at 4 degrees for not longer than 48 hours
IMMUNOHEMATOLOGY EXAM
What type of serological testing does the blood bank technologist perform when
determining the blood group of a patient? - Correct Answers -Phenotyping
If anti-K reacts 3+ with a donor cell with a genotype KK and 2+ with a Kk cell, the
antibody is demonstrating: - Correct Answers -Dosage
Carla expresses the blood group antigens FyA, FyB, and XgA. James shoes
expressions of none of these antigens. What factor may account for the absence of
these antigens in James? - Correct Answers -Gender
Which of the following statements is true? - Correct Answers -An individual with the BB
genotype is homozygous for B antigen
Which genotype will give rise to the Bombay phenotype? - Correct Answers -hh only
Meiosis in cell division is limited to the ova and sperm producing four gametes
containing what complement of DNA? - Correct Answers -1N
A cell that is not actively dividing is said to be in : - Correct Answers -Interphase
Which of the following describes the expression of most blood group antigens? - Correct
Answers -Codominant
What blood type is not possible for an offspring of AO and BO mating? - Correct
Answers -All are possible
The alleged father of a child in a disputed case of paternity is blood group AB. The
mother and child are group O. What type of exclusion is this? - Correct Answers -
Indirect/secondary/second order
If the frequency of gene Y is 0.4 and the frequency of gene Z is 0.5, one would expect
that they should occur together 0.2 (20%) of the time. In actuality, they are found
together 32% of the time. This is an example of: - Correct Answers -Linkage
disequilibrium
In the Hardy-Weinberg formula, p2 represents... - Correct Answers -The homozygous
population of one allele
, In this type of inheritance, the father carries the trait on his X chromosome. The has no
sons with the trait because he passed his y chromosome to them; however, all his
daughters will express the trait. - Correct Answers -X-linked dominant
Why do IgM antibodies, such as those formed against the ABO antigens, have the
ability to directly agglutinate red blood cells and cause visible agglutination? - Correct
Answers -IgM antibodies are larger molecule and have the ability to bind more antigen
Which of the following enhancement mediums decreases the zeta potential, allowing
antibody and antigen to come closer together? - Correct Answers -LISS
This type of antibody response is analogous to an anamnestic antibody reaction. -
Correct Answers -Secondary
Which antibodies to a component of complement are contained in the rabbit polyspecific
antihuman globulin reagent for detection of in vitro sensitization? - Correct Answers -
Anit-IgG and anti-C3d
Which distinguishes A1 from A@ blood groups? - Correct Answers -An A2 person may
form anti-A1; and A1 person will not for anti-A1
A patient's serum is incompatible with O cells. The patient RBCs give a negative
reaction to anti-H lectin. What is the most likely cause of these results? - Correct
Answers -The patient may be a Bombay
What antibodies are formed by a Bombay individual? - Correct Answers -Anti-A, B, and
H
Acquired B antigens have been found in - Correct Answers -Group A persons
Blood is crossmatched on an A pos person with a negative antibody screen, The patient
received a transfusion of A positive RBCs 3 years agao. The donors chosen for
crossmatch were A positive. The crossmatch was run on the Ortho Provue and yielded
3+ incompatibility. How can these results be explained? - Correct Answers -The patient
has an A2 with anti A1
A patient's red cells forward as group O, serum agglutinates B cells (4+) only. Your next
step would be: - Correct Answers -Incubate washed red cells with anti-A1 and anti-A, B
for 30 minutes at RT
Which typing results are most likely to occur when a patient has an acquired B antigen?
- Correct Answers -Anti-A 4+, anti-B 1+, A1 cells neg, B cells 4+
What sample is best for detecting complement-dependent antibodies? - Correct
Answers -Serum stored at 4 degrees for not longer than 48 hours
