HESI LPN - ADN ENTRANCE EXAM
TEST BANK ACTUAL 2026/2027
HIGH YIELD PRACTICE
QUESTIONS AND STUDY GUIDE
HESI LPN - ADN ENTRANCE EXAM TEST | Comprehensive
Examination
HESI LPN - ADN ENTRANCE EXAM TEST BANK
ACTUAL 2026/2027 HIGH YIELD PRACTICE
QUESTIONS AND STUDY GUIDE COMPLETE
INTRODUCTION
This document is an important and very helpful preparation
resource for HESI LPN - ADN ENTRANCE EXAM TEST
BANK ACTUAL 2026/2027 HIGH YIELD PRACTICE
QUESTIONS AND STUDY GUIDE COMPLETE ACCURATE
EXAM REAL QUESTIONS AND CORRECT VERIFIED
SOLUTIONS WITH DETAILED RATIONALES (100%
RELIABLE ANSWERS) CURRENTLY UPDATED VERSION
2026 EDIT. Every item uses a focused exam stem, four response
options, a keyed response, and a clear rationale, making it
easier to understand the subject, spot distractors, and build real
exam confidence.
Page 1
, Question 1
Which cellular process directly explains why a patient with a mitochondrial
disorder experiences profound fatigue and lactic acidosis after minimal
exertion?
A. Impaired oxidative phosphorylation forces reliance on anaerobic
glycolysis.
B. Defective ribosomal translation reduces contractile protein synthesis.
C. Golgi apparatus dysfunction prevents post-translational modification
of enzymes.
D. Lysosomal enzyme deficiency causes accumulation of glycogen in
muscle.
Correct Answer: A - Impaired oxidative phosphorylation forces
reliance on anaerobic glycolysis.
RATIONALE
Mitochondria produce ATP via oxidative phosphorylation; when
impaired, cells shift to anaerobic glycolysis, yielding less ATP and
excess lactate. Ribosomal, Golgi, and lysosomal defects do not
directly cause lactic acidosis with exertion.
Question 2
A nurse must administer 0.5 g of a medication available as 250 mg/5 mL.
Using dimensional analysis, how many mL will the nurse administer?
A. 5 mL
B. 10 mL
C. 2.5 mL
D. 20 mL
Correct Answer: B - 10 mL
Page 2
, RATIONALE
Convert 0.5 g to 500 mg. Then (500 mg) × (5 mL / 250 mg) = 10 mL.
Options A, C, and D result from incorrect conversion or inversion of
the ratio.
Question 3
A patient with a central line develops sudden fever, chills, and hypotension.
Blood cultures grow gram-positive cocci in clusters that are catalase-positive
and coagulase-positive. Which organism is most likely?
A. Staphylococcus epidermidis
B. Streptococcus pyogenes
C. Staphylococcus aureus
D. Enterococcus faecalis
Correct Answer: C - Staphylococcus aureus
RATIONALE
Coagulase-positive, catalase-positive gram-positive cocci in clusters
identify Staphylococcus aureus. S. epidermidis is coagulase-negative;
S. pyogenes is catalase-negative and forms chains; Enterococcus is
catalase-negative and often in pairs/chains.
Question 4
In a study examining the relationship between nurse staffing ratios and patient
falls, which statistical test is most appropriate to compare fall rates between
two independent groups with non-normal distributions?
A. Independent samples t-test
B. Mann-Whitney U test
C. Chi-square test
D. Pearson correlation
Correct Answer: B - Mann-Whitney U test
Page 3
, RATIONALE
The Mann-Whitney U test is a non-parametric alternative to the t-test
for comparing two independent groups when normality is violated.
T-test assumes normality; chi-square compares categorical
frequencies; Pearson correlation assesses linear association between
continuous variables.
Question 5
A provider orders 1000 mL of 0.9% NaCl to infuse over 8 hours. The drop
factor is 15 gtt/mL. What is the flow rate in drops per minute?
A. 31 gtt/min
B. 21 gtt/min
C. 42 gtt/min
D. 15 gtt/min
Correct Answer: A - 31 gtt/min
RATIONALE
Flow rate = (1000 mL × 15 gtt/mL) / (8 h × 60 min/h) =
31.25, rounded to 31 gtt/min. Other options reflect calculation errors.
Question 6
Which of the following best illustrates the concept of 'confidentiality' as
applied to a nurse discussing a patient's case in a public elevator?
A. The nurse is violating HIPAA by disclosing protected health
information.
B. The nurse is allowed to discuss if no names are used.
C. The nurse is exempt because the discussion is for educational
purposes.
D. The nurse is not liable if the patient consents verbally.
Correct Answer: A - The nurse is violating HIPAA by disclosing
protected health information.
Page 4
TEST BANK ACTUAL 2026/2027
HIGH YIELD PRACTICE
QUESTIONS AND STUDY GUIDE
HESI LPN - ADN ENTRANCE EXAM TEST | Comprehensive
Examination
HESI LPN - ADN ENTRANCE EXAM TEST BANK
ACTUAL 2026/2027 HIGH YIELD PRACTICE
QUESTIONS AND STUDY GUIDE COMPLETE
INTRODUCTION
This document is an important and very helpful preparation
resource for HESI LPN - ADN ENTRANCE EXAM TEST
BANK ACTUAL 2026/2027 HIGH YIELD PRACTICE
QUESTIONS AND STUDY GUIDE COMPLETE ACCURATE
EXAM REAL QUESTIONS AND CORRECT VERIFIED
SOLUTIONS WITH DETAILED RATIONALES (100%
RELIABLE ANSWERS) CURRENTLY UPDATED VERSION
2026 EDIT. Every item uses a focused exam stem, four response
options, a keyed response, and a clear rationale, making it
easier to understand the subject, spot distractors, and build real
exam confidence.
Page 1
, Question 1
Which cellular process directly explains why a patient with a mitochondrial
disorder experiences profound fatigue and lactic acidosis after minimal
exertion?
A. Impaired oxidative phosphorylation forces reliance on anaerobic
glycolysis.
B. Defective ribosomal translation reduces contractile protein synthesis.
C. Golgi apparatus dysfunction prevents post-translational modification
of enzymes.
D. Lysosomal enzyme deficiency causes accumulation of glycogen in
muscle.
Correct Answer: A - Impaired oxidative phosphorylation forces
reliance on anaerobic glycolysis.
RATIONALE
Mitochondria produce ATP via oxidative phosphorylation; when
impaired, cells shift to anaerobic glycolysis, yielding less ATP and
excess lactate. Ribosomal, Golgi, and lysosomal defects do not
directly cause lactic acidosis with exertion.
Question 2
A nurse must administer 0.5 g of a medication available as 250 mg/5 mL.
Using dimensional analysis, how many mL will the nurse administer?
A. 5 mL
B. 10 mL
C. 2.5 mL
D. 20 mL
Correct Answer: B - 10 mL
Page 2
, RATIONALE
Convert 0.5 g to 500 mg. Then (500 mg) × (5 mL / 250 mg) = 10 mL.
Options A, C, and D result from incorrect conversion or inversion of
the ratio.
Question 3
A patient with a central line develops sudden fever, chills, and hypotension.
Blood cultures grow gram-positive cocci in clusters that are catalase-positive
and coagulase-positive. Which organism is most likely?
A. Staphylococcus epidermidis
B. Streptococcus pyogenes
C. Staphylococcus aureus
D. Enterococcus faecalis
Correct Answer: C - Staphylococcus aureus
RATIONALE
Coagulase-positive, catalase-positive gram-positive cocci in clusters
identify Staphylococcus aureus. S. epidermidis is coagulase-negative;
S. pyogenes is catalase-negative and forms chains; Enterococcus is
catalase-negative and often in pairs/chains.
Question 4
In a study examining the relationship between nurse staffing ratios and patient
falls, which statistical test is most appropriate to compare fall rates between
two independent groups with non-normal distributions?
A. Independent samples t-test
B. Mann-Whitney U test
C. Chi-square test
D. Pearson correlation
Correct Answer: B - Mann-Whitney U test
Page 3
, RATIONALE
The Mann-Whitney U test is a non-parametric alternative to the t-test
for comparing two independent groups when normality is violated.
T-test assumes normality; chi-square compares categorical
frequencies; Pearson correlation assesses linear association between
continuous variables.
Question 5
A provider orders 1000 mL of 0.9% NaCl to infuse over 8 hours. The drop
factor is 15 gtt/mL. What is the flow rate in drops per minute?
A. 31 gtt/min
B. 21 gtt/min
C. 42 gtt/min
D. 15 gtt/min
Correct Answer: A - 31 gtt/min
RATIONALE
Flow rate = (1000 mL × 15 gtt/mL) / (8 h × 60 min/h) =
31.25, rounded to 31 gtt/min. Other options reflect calculation errors.
Question 6
Which of the following best illustrates the concept of 'confidentiality' as
applied to a nurse discussing a patient's case in a public elevator?
A. The nurse is violating HIPAA by disclosing protected health
information.
B. The nurse is allowed to discuss if no names are used.
C. The nurse is exempt because the discussion is for educational
purposes.
D. The nurse is not liable if the patient consents verbally.
Correct Answer: A - The nurse is violating HIPAA by disclosing
protected health information.
Page 4
