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NCLEX Nursing Exam 2026/2027 – Infection Control, Safety & Patient Care Practice Questions

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Prepare for the NCLEX Nursing Exam 2026/2027 with focused practice questions covering infection prevention and control, standard and transmission-based precautions, personal protective equipment, patient safety, fall prevention, safe patient care, emergency response, hazardous and infectious materials, medication safety, incident reporting, and clinical judgment. This study resource is designed to support nursing students reviewing safety, infection control, and patient-care concepts aligned with the current 2026 NCLEX-RN Test Plan.

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NCLEX Nursing Exam | Infection Control, Safety & Patient Care | Practice Questions & Verified Answers




Which patient is at the highest risk for A 78-year-old receiving broad-spectrum IV antibiotics
developing a Health Care-Associated with an indwelling urinary catheter.
Infection (HAI)?


What factors directly contribute to the Invasive medical procedures, administration of broad-
development of Health Care-Associated spectrum antibiotics, proliferation of Multidrug-Resistant
Infections (HAIs)? Organisms (MDROs), breaks in infection prevention
and control activities.


Which host factors influence infection Age, sex, nutritional status, stress levels, disease
prevention and control? process.



What are the primary goals of nursing Eliminate the infectious organism and support the
care for a patient with a severe bacterial patient's defenses.
infection?


What health promotion measures are Nutrition, hygiene, immunization, adequate rest, and
essential for boosting host defenses regular exercise.
against infectious pathogens?


Which patient should the nurse assess An 82-year-old malnourished patient with severe
first based on risk for systemic chronic stress and an indwelling IV line.
infection?


What mechanism explains the Antibiotic administration disrupting normal protective
occurrence of Clostridioides difficile flora and facilitating MDRO/pathogen growth.
infection after prolonged antibiotic
therapy?


What cluster of assessment findings Advanced age, poor nutritional status, chronic stress,
represents host susceptibility factors? disease process (diabetes), and invasive device.



What cause of HAIs is classified when a Break in infection prevention and control activities.
healthcare worker fails to perform hand
hygiene?


What recommendation helps reduce Maintain balanced nutrition, practice diligent hygiene,
susceptibility to viral respiratory ensure immunizations are current, and get adequate
illnesses? rest and exercise.


Grade A+ | Updated

, NCLEX Nursing Exam | Infection Control, Safety & Patient Care | Practice Questions & Verified Answers



What is the correct priority order for 3, 2, 1, 4.
managing an acute bacterial wound
infection?


Which intervention directly supports a Providing high-protein nutritional support and ensuring
patient's host defenses in severe adequate oxygenation and rest.
sepsis?


Which organisms are classified as Methicillin-Resistant Staphylococcus aureus (MRSA),
Multidrug-Resistant Organisms Vancomycin-Resistant Enterococcus (VRE),
(MDROs)? Carbapenem-Resistant Enterobacteriaceae (CRE).


Why does severe psychological or Stress alters immune response and elevates cortisol,
physical stress increase vulnerability to suppressing host defenses.
infection?


How many HAI risk factors does an Multiple risk factors due to disease process and
elderly patient with chronic kidney invasive procedure.
disease and malnutrition have?


How many HAI risk factors does the Four (Age, Disease process, Nutritional status, Invasive
patient have according to the Dinosaur procedure)
slides?


What is the focus of health promotion in Health promotion focuses on nutrition, hygiene,
infection control? immunizations, and rest to prevent illness, whereas
acute care focuses on eliminating organisms and
supporting defenses during illness.


What action by the nurse represents a Re-using a single-use urinary drainage container
direct break in infection control between two patients without disinfection.
activities?


Why are pediatric and geriatric patients Age significantly influences infection susceptibility due
at elevated risk for infection? to immature or senescent immune systems.



How is a patient with a central venous Health Care-Associated Infection (HAI) related to an
catheter and positive blood cultures for invasive procedure.
Staphylococcus aureus categorized?




Grade A+ | Updated

, NCLEX Nursing Exam | Infection Control, Safety & Patient Care | Practice Questions & Verified Answers



Which interventions should the nurse Administer prescribed parenteral or oral enteral
include to support a patient's natural nutrition as tolerated, encourage uninterrupted periods
defenses during acute infection of rest to lower metabolic demands, maintain adequate
treatment? fluid and electrolyte balance, administer prescribed
antimicrobial therapy on time.


What intervention addresses a core Audit staff compliance with sterile technique and hand
cause of HAIs in surgical site hygiene during surgical prep and wound care.
infections?


How does poor nutritional status impair Inadequate protein and caloric intake impairs tissue
a host's ability to prevent infection? repair and antibody synthesis.



What is the key component of Health promotion to enhance specific immune defenses
immunization for healthy adults? before exposure.



How do stress and disease process They significantly elevate the patient's overall risk for
interact to affect HAI risk? acquiring an HAI.



What are essential components of Hand hygiene before and after patient contact,
standard hygiene protocols to promote performing oral care to maintain intact mucous
health? membranes, cleansing skin to reduce bacterial bioload,
maintaining clean, dry bed linens.


What action must the nurse take for Verify the patient's identity using at least two unique
proper patient identification before identifiers (e.g., full name and date of birth).
administering medication?


What environmental finding in Mrs. Multiple unsecured throw rugs and cluttered magazines
Cohen's home requires immediate on the living room floor.
intervention?


Which clinical assessment findings Dragging the left foot when ambulating, weak hand
indicate a high risk for falls in a post- grasp when holding an assistive device, unsteady gait
stroke patient? and impaired standing balance, history of a fall within
the past 12 months.


How does CMS treat a Stage 3 CMS classifies it as a Never Event / Hospital-Acquired
pressure injury developed during a Condition and will not provide additional payment for
hospital stay? treatment.

Grade A+ | Updated

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