Comprehensive Professional Nursing
Examination: Hirschsprung's Disease
Target Audience: Pediatric Nurses, Registered Nurses (RN),
NCLEX-RN Candidates
Scope: 200 Multiple-Choice Questions with Complete Clinical
Rationales
Module 1: Pathophysiology & Etiology
Question 1: Which embryonic developmental mechanism is
primarily responsible for the pathophysiology of Hirschsprung's
disease (congenital aganglionic megacolon)?
A. Failure of neural crest cell migration along the gastrointestinal
tract during weeks 5 to 12 of gestation.
B. Hypertrophy of the circular muscle layer of the pylorus leading
to gastric outlet obstruction.
C. Premature closure of the neural tube resulting in autonomic
innervation failure of the distal colon.
D. Immune-mediated destruction of myenteric (Auerbach's)
plexuses postnatally.
Correct Answer: A
Rationale: Hirschsprung's disease results from the failure of
craniocaudal migration of vagal neural crest cells into the bowel
wall between the 5th and 12th weeks of gestation, resulting in an
absence of ganglion cells (aganglionosis) in the myenteric and
submucosal plexuses.
,Question 2: Which embryonic developmental mechanism is
primarily responsible for the pathophysiology of Hirschsprung's
disease (congenital aganglionic megacolon)?
A. Failure of neural crest cell migration along the gastrointestinal
tract during weeks 5 to 12 of gestation.
B. Hypertrophy of the circular muscle layer of the pylorus leading
to gastric outlet obstruction.
C. Premature closure of the neural tube resulting in autonomic
innervation failure of the distal colon.
D. Immune-mediated destruction of myenteric (Auerbach's)
plexuses postnatally.
Correct Answer: A
Rationale: Hirschsprung's disease results from the failure of
craniocaudal migration of vagal neural crest cells into the bowel
wall between the 5th and 12th weeks of gestation, resulting in an
absence of ganglion cells (aganglionosis) in the myenteric and
submucosal plexuses.
Question 3: Which embryonic developmental mechanism is
primarily responsible for the pathophysiology of Hirschsprung's
disease (congenital aganglionic megacolon)?
A. Failure of neural crest cell migration along the gastrointestinal
tract during weeks 5 to 12 of gestation.
,B. Hypertrophy of the circular muscle layer of the pylorus leading
to gastric outlet obstruction.
C. Premature closure of the neural tube resulting in autonomic
innervation failure of the distal colon.
D. Immune-mediated destruction of myenteric (Auerbach's)
plexuses postnatally.
Correct Answer: A
Rationale: Hirschsprung's disease results from the failure of
craniocaudal migration of vagal neural crest cells into the bowel
wall between the 5th and 12th weeks of gestation, resulting in an
absence of ganglion cells (aganglionosis) in the myenteric and
submucosal plexuses.
Question 4: Which embryonic developmental mechanism is
primarily responsible for the pathophysiology of Hirschsprung's
disease (congenital aganglionic megacolon)?
A. Failure of neural crest cell migration along the gastrointestinal
tract during weeks 5 to 12 of gestation.
B. Hypertrophy of the circular muscle layer of the pylorus leading
to gastric outlet obstruction.
C. Premature closure of the neural tube resulting in autonomic
innervation failure of the distal colon.
D. Immune-mediated destruction of myenteric (Auerbach's)
plexuses postnatally.
Correct Answer: A
, Rationale: Hirschsprung's disease results from the failure of
craniocaudal migration of vagal neural crest cells into the bowel
wall between the 5th and 12th weeks of gestation, resulting in an
absence of ganglion cells (aganglionosis) in the myenteric and
submucosal plexuses.
Question 5: Which embryonic developmental mechanism is
primarily responsible for the pathophysiology of Hirschsprung's
disease (congenital aganglionic megacolon)?
A. Failure of neural crest cell migration along the gastrointestinal
tract during weeks 5 to 12 of gestation.
B. Hypertrophy of the circular muscle layer of the pylorus leading
to gastric outlet obstruction.
C. Premature closure of the neural tube resulting in autonomic
innervation failure of the distal colon.
D. Immune-mediated destruction of myenteric (Auerbach's)
plexuses postnatally.
Correct Answer: A
Rationale: Hirschsprung's disease results from the failure of
craniocaudal migration of vagal neural crest cells into the bowel
wall between the 5th and 12th weeks of gestation, resulting in an
absence of ganglion cells (aganglionosis) in the myenteric and
submucosal plexuses.
Examination: Hirschsprung's Disease
Target Audience: Pediatric Nurses, Registered Nurses (RN),
NCLEX-RN Candidates
Scope: 200 Multiple-Choice Questions with Complete Clinical
Rationales
Module 1: Pathophysiology & Etiology
Question 1: Which embryonic developmental mechanism is
primarily responsible for the pathophysiology of Hirschsprung's
disease (congenital aganglionic megacolon)?
A. Failure of neural crest cell migration along the gastrointestinal
tract during weeks 5 to 12 of gestation.
B. Hypertrophy of the circular muscle layer of the pylorus leading
to gastric outlet obstruction.
C. Premature closure of the neural tube resulting in autonomic
innervation failure of the distal colon.
D. Immune-mediated destruction of myenteric (Auerbach's)
plexuses postnatally.
Correct Answer: A
Rationale: Hirschsprung's disease results from the failure of
craniocaudal migration of vagal neural crest cells into the bowel
wall between the 5th and 12th weeks of gestation, resulting in an
absence of ganglion cells (aganglionosis) in the myenteric and
submucosal plexuses.
,Question 2: Which embryonic developmental mechanism is
primarily responsible for the pathophysiology of Hirschsprung's
disease (congenital aganglionic megacolon)?
A. Failure of neural crest cell migration along the gastrointestinal
tract during weeks 5 to 12 of gestation.
B. Hypertrophy of the circular muscle layer of the pylorus leading
to gastric outlet obstruction.
C. Premature closure of the neural tube resulting in autonomic
innervation failure of the distal colon.
D. Immune-mediated destruction of myenteric (Auerbach's)
plexuses postnatally.
Correct Answer: A
Rationale: Hirschsprung's disease results from the failure of
craniocaudal migration of vagal neural crest cells into the bowel
wall between the 5th and 12th weeks of gestation, resulting in an
absence of ganglion cells (aganglionosis) in the myenteric and
submucosal plexuses.
Question 3: Which embryonic developmental mechanism is
primarily responsible for the pathophysiology of Hirschsprung's
disease (congenital aganglionic megacolon)?
A. Failure of neural crest cell migration along the gastrointestinal
tract during weeks 5 to 12 of gestation.
,B. Hypertrophy of the circular muscle layer of the pylorus leading
to gastric outlet obstruction.
C. Premature closure of the neural tube resulting in autonomic
innervation failure of the distal colon.
D. Immune-mediated destruction of myenteric (Auerbach's)
plexuses postnatally.
Correct Answer: A
Rationale: Hirschsprung's disease results from the failure of
craniocaudal migration of vagal neural crest cells into the bowel
wall between the 5th and 12th weeks of gestation, resulting in an
absence of ganglion cells (aganglionosis) in the myenteric and
submucosal plexuses.
Question 4: Which embryonic developmental mechanism is
primarily responsible for the pathophysiology of Hirschsprung's
disease (congenital aganglionic megacolon)?
A. Failure of neural crest cell migration along the gastrointestinal
tract during weeks 5 to 12 of gestation.
B. Hypertrophy of the circular muscle layer of the pylorus leading
to gastric outlet obstruction.
C. Premature closure of the neural tube resulting in autonomic
innervation failure of the distal colon.
D. Immune-mediated destruction of myenteric (Auerbach's)
plexuses postnatally.
Correct Answer: A
, Rationale: Hirschsprung's disease results from the failure of
craniocaudal migration of vagal neural crest cells into the bowel
wall between the 5th and 12th weeks of gestation, resulting in an
absence of ganglion cells (aganglionosis) in the myenteric and
submucosal plexuses.
Question 5: Which embryonic developmental mechanism is
primarily responsible for the pathophysiology of Hirschsprung's
disease (congenital aganglionic megacolon)?
A. Failure of neural crest cell migration along the gastrointestinal
tract during weeks 5 to 12 of gestation.
B. Hypertrophy of the circular muscle layer of the pylorus leading
to gastric outlet obstruction.
C. Premature closure of the neural tube resulting in autonomic
innervation failure of the distal colon.
D. Immune-mediated destruction of myenteric (Auerbach's)
plexuses postnatally.
Correct Answer: A
Rationale: Hirschsprung's disease results from the failure of
craniocaudal migration of vagal neural crest cells into the bowel
wall between the 5th and 12th weeks of gestation, resulting in an
absence of ganglion cells (aganglionosis) in the myenteric and
submucosal plexuses.
