NCLEX-RN PHARMACOLOGY MASTERY: 330 QUESTIONS
WITH RATIONALES - DRUG CLASSES, SIDE EFFECTS &
NURSING CONSIDERATIONS
NCLEX-RN Pharmacology Mastery: 330 Questions with Rationales - Drug Classes, Side Effects &
Nursing Considerations
Course: Pharmacology | Total: 330 Questions | Format: Q + Options + Answer + Rationale | Edition: 2026 NCLEX-RN
High-Yield | Author: Original Content
All questions are original and based on current nursing textbooks (Lewis, Saunders, ATI). Not copied from any exam bank.
[1] Opioid overdose triad?
Respiratory depression, pinpoint pupils, decreased LOC
Tachycardia, hypertension
Dilated pupils
Agitation
Correct Answer: A
Rationale: Opioid overdose: respiratory depression, pinpoint pupils, CNS depression. Antidote naloxone.
[2] Gentamicin side effect?
Nephrotoxicity and ototoxicity
Hyperkalemia only
No side effects
Weight loss only
Correct Answer: A
Rationale: Aminoglycosides: nephrotoxic (monitor creatinine), ototoxic (hearing loss, tinnitus), check peak/trough.
[3] Long-term steroid teaching?
Take with food in AM, do not stop abruptly, monitor blood sugar
Take on empty stomach at night
Stop suddenly
No need to monitor
Correct Answer: A
Rationale: Steroids: take AM with food, taper, increase infection risk, hyperglycemia, weight gain, osteoporosis, GI bleed.
[4] Foods high in Vitamin K?
Green leafy vegetables: spinach, kale, broccoli
Apples
Rice
Chicken
Correct Answer: A
Rationale: Vitamin K reverses warfarin. Keep intake consistent, not avoid, but consistent.
[5] Opioid overdose triad?
Respiratory depression, pinpoint pupils, decreased LOC
Tachycardia, hypertension
Dilated pupils
Agitation
Correct Answer: A
Rationale: Opioid overdose: respiratory depression, pinpoint pupils, CNS depression. Antidote naloxone.
,[6] Gentamicin side effect?
Nephrotoxicity and ototoxicity
Hyperkalemia only
No side effects
Weight loss only
Correct Answer: A
Rationale: Aminoglycosides: nephrotoxic (monitor creatinine), ototoxic (hearing loss, tinnitus), check peak/trough.
[7] Long-term steroid teaching?
Take with food in AM, do not stop abruptly, monitor blood sugar
Take on empty stomach at night
Stop suddenly
No need to monitor
Correct Answer: A
Rationale: Steroids: take AM with food, taper, increase infection risk, hyperglycemia, weight gain, osteoporosis, GI bleed.
[8] Foods high in Vitamin K?
Green leafy vegetables: spinach, kale, broccoli
Apples
Rice
Chicken
Correct Answer: A
Rationale: Vitamin K reverses warfarin. Keep intake consistent, not avoid, but consistent.
[9] Opioid overdose triad?
Respiratory depression, pinpoint pupils, decreased LOC
Tachycardia, hypertension
Dilated pupils
Agitation
Correct Answer: A
Rationale: Opioid overdose: respiratory depression, pinpoint pupils, CNS depression. Antidote naloxone.
[10] Gentamicin side effect?
Nephrotoxicity and ototoxicity
Hyperkalemia only
No side effects
Weight loss only
Correct Answer: A
Rationale: Aminoglycosides: nephrotoxic (monitor creatinine), ototoxic (hearing loss, tinnitus), check peak/trough.
[11] Long-term steroid teaching?
Take with food in AM, do not stop abruptly, monitor blood sugar
Take on empty stomach at night
Stop suddenly
No need to monitor
Correct Answer: A
Rationale: Steroids: take AM with food, taper, increase infection risk, hyperglycemia, weight gain, osteoporosis, GI bleed.
[12] Foods high in Vitamin K?
Green leafy vegetables: spinach, kale, broccoli
Apples
Rice
, Chicken
Correct Answer: A
Rationale: Vitamin K reverses warfarin. Keep intake consistent, not avoid, but consistent.
[13] Opioid overdose triad?
Respiratory depression, pinpoint pupils, decreased LOC
Tachycardia, hypertension
Dilated pupils
Agitation
Correct Answer: A
Rationale: Opioid overdose: respiratory depression, pinpoint pupils, CNS depression. Antidote naloxone.
[14] Gentamicin side effect?
Nephrotoxicity and ototoxicity
Hyperkalemia only
No side effects
Weight loss only
Correct Answer: A
Rationale: Aminoglycosides: nephrotoxic (monitor creatinine), ototoxic (hearing loss, tinnitus), check peak/trough.
[15] Long-term steroid teaching?
Take with food in AM, do not stop abruptly, monitor blood sugar
Take on empty stomach at night
Stop suddenly
No need to monitor
Correct Answer: A
Rationale: Steroids: take AM with food, taper, increase infection risk, hyperglycemia, weight gain, osteoporosis, GI bleed.
[16] Foods high in Vitamin K?
Green leafy vegetables: spinach, kale, broccoli
Apples
Rice
Chicken
Correct Answer: A
Rationale: Vitamin K reverses warfarin. Keep intake consistent, not avoid, but consistent.
[17] Opioid overdose triad?
Respiratory depression, pinpoint pupils, decreased LOC
Tachycardia, hypertension
Dilated pupils
Agitation
Correct Answer: A
Rationale: Opioid overdose: respiratory depression, pinpoint pupils, CNS depression. Antidote naloxone.
[18] Gentamicin side effect?
Nephrotoxicity and ototoxicity
Hyperkalemia only
No side effects
Weight loss only
Correct Answer: A
Rationale: Aminoglycosides: nephrotoxic (monitor creatinine), ototoxic (hearing loss, tinnitus), check peak/trough.
[19] Long-term steroid teaching?
, Take with food in AM, do not stop abruptly, monitor blood sugar
Take on empty stomach at night
Stop suddenly
No need to monitor
Correct Answer: A
Rationale: Steroids: take AM with food, taper, increase infection risk, hyperglycemia, weight gain, osteoporosis, GI bleed.
[20] Foods high in Vitamin K?
Green leafy vegetables: spinach, kale, broccoli
Apples
Rice
Chicken
Correct Answer: A
Rationale: Vitamin K reverses warfarin. Keep intake consistent, not avoid, but consistent.
[21] Opioid overdose triad?
Respiratory depression, pinpoint pupils, decreased LOC
Tachycardia, hypertension
Dilated pupils
Agitation
Correct Answer: A
Rationale: Opioid overdose: respiratory depression, pinpoint pupils, CNS depression. Antidote naloxone.
[22] Gentamicin side effect?
Nephrotoxicity and ototoxicity
Hyperkalemia only
No side effects
Weight loss only
Correct Answer: A
Rationale: Aminoglycosides: nephrotoxic (monitor creatinine), ototoxic (hearing loss, tinnitus), check peak/trough.
[23] Long-term steroid teaching?
Take with food in AM, do not stop abruptly, monitor blood sugar
Take on empty stomach at night
Stop suddenly
No need to monitor
Correct Answer: A
Rationale: Steroids: take AM with food, taper, increase infection risk, hyperglycemia, weight gain, osteoporosis, GI bleed.
[24] Foods high in Vitamin K?
Green leafy vegetables: spinach, kale, broccoli
Apples
Rice
Chicken
Correct Answer: A
Rationale: Vitamin K reverses warfarin. Keep intake consistent, not avoid, but consistent.
[25] Opioid overdose triad?
Respiratory depression, pinpoint pupils, decreased LOC
Tachycardia, hypertension
Dilated pupils
Agitation
WITH RATIONALES - DRUG CLASSES, SIDE EFFECTS &
NURSING CONSIDERATIONS
NCLEX-RN Pharmacology Mastery: 330 Questions with Rationales - Drug Classes, Side Effects &
Nursing Considerations
Course: Pharmacology | Total: 330 Questions | Format: Q + Options + Answer + Rationale | Edition: 2026 NCLEX-RN
High-Yield | Author: Original Content
All questions are original and based on current nursing textbooks (Lewis, Saunders, ATI). Not copied from any exam bank.
[1] Opioid overdose triad?
Respiratory depression, pinpoint pupils, decreased LOC
Tachycardia, hypertension
Dilated pupils
Agitation
Correct Answer: A
Rationale: Opioid overdose: respiratory depression, pinpoint pupils, CNS depression. Antidote naloxone.
[2] Gentamicin side effect?
Nephrotoxicity and ototoxicity
Hyperkalemia only
No side effects
Weight loss only
Correct Answer: A
Rationale: Aminoglycosides: nephrotoxic (monitor creatinine), ototoxic (hearing loss, tinnitus), check peak/trough.
[3] Long-term steroid teaching?
Take with food in AM, do not stop abruptly, monitor blood sugar
Take on empty stomach at night
Stop suddenly
No need to monitor
Correct Answer: A
Rationale: Steroids: take AM with food, taper, increase infection risk, hyperglycemia, weight gain, osteoporosis, GI bleed.
[4] Foods high in Vitamin K?
Green leafy vegetables: spinach, kale, broccoli
Apples
Rice
Chicken
Correct Answer: A
Rationale: Vitamin K reverses warfarin. Keep intake consistent, not avoid, but consistent.
[5] Opioid overdose triad?
Respiratory depression, pinpoint pupils, decreased LOC
Tachycardia, hypertension
Dilated pupils
Agitation
Correct Answer: A
Rationale: Opioid overdose: respiratory depression, pinpoint pupils, CNS depression. Antidote naloxone.
,[6] Gentamicin side effect?
Nephrotoxicity and ototoxicity
Hyperkalemia only
No side effects
Weight loss only
Correct Answer: A
Rationale: Aminoglycosides: nephrotoxic (monitor creatinine), ototoxic (hearing loss, tinnitus), check peak/trough.
[7] Long-term steroid teaching?
Take with food in AM, do not stop abruptly, monitor blood sugar
Take on empty stomach at night
Stop suddenly
No need to monitor
Correct Answer: A
Rationale: Steroids: take AM with food, taper, increase infection risk, hyperglycemia, weight gain, osteoporosis, GI bleed.
[8] Foods high in Vitamin K?
Green leafy vegetables: spinach, kale, broccoli
Apples
Rice
Chicken
Correct Answer: A
Rationale: Vitamin K reverses warfarin. Keep intake consistent, not avoid, but consistent.
[9] Opioid overdose triad?
Respiratory depression, pinpoint pupils, decreased LOC
Tachycardia, hypertension
Dilated pupils
Agitation
Correct Answer: A
Rationale: Opioid overdose: respiratory depression, pinpoint pupils, CNS depression. Antidote naloxone.
[10] Gentamicin side effect?
Nephrotoxicity and ototoxicity
Hyperkalemia only
No side effects
Weight loss only
Correct Answer: A
Rationale: Aminoglycosides: nephrotoxic (monitor creatinine), ototoxic (hearing loss, tinnitus), check peak/trough.
[11] Long-term steroid teaching?
Take with food in AM, do not stop abruptly, monitor blood sugar
Take on empty stomach at night
Stop suddenly
No need to monitor
Correct Answer: A
Rationale: Steroids: take AM with food, taper, increase infection risk, hyperglycemia, weight gain, osteoporosis, GI bleed.
[12] Foods high in Vitamin K?
Green leafy vegetables: spinach, kale, broccoli
Apples
Rice
, Chicken
Correct Answer: A
Rationale: Vitamin K reverses warfarin. Keep intake consistent, not avoid, but consistent.
[13] Opioid overdose triad?
Respiratory depression, pinpoint pupils, decreased LOC
Tachycardia, hypertension
Dilated pupils
Agitation
Correct Answer: A
Rationale: Opioid overdose: respiratory depression, pinpoint pupils, CNS depression. Antidote naloxone.
[14] Gentamicin side effect?
Nephrotoxicity and ototoxicity
Hyperkalemia only
No side effects
Weight loss only
Correct Answer: A
Rationale: Aminoglycosides: nephrotoxic (monitor creatinine), ototoxic (hearing loss, tinnitus), check peak/trough.
[15] Long-term steroid teaching?
Take with food in AM, do not stop abruptly, monitor blood sugar
Take on empty stomach at night
Stop suddenly
No need to monitor
Correct Answer: A
Rationale: Steroids: take AM with food, taper, increase infection risk, hyperglycemia, weight gain, osteoporosis, GI bleed.
[16] Foods high in Vitamin K?
Green leafy vegetables: spinach, kale, broccoli
Apples
Rice
Chicken
Correct Answer: A
Rationale: Vitamin K reverses warfarin. Keep intake consistent, not avoid, but consistent.
[17] Opioid overdose triad?
Respiratory depression, pinpoint pupils, decreased LOC
Tachycardia, hypertension
Dilated pupils
Agitation
Correct Answer: A
Rationale: Opioid overdose: respiratory depression, pinpoint pupils, CNS depression. Antidote naloxone.
[18] Gentamicin side effect?
Nephrotoxicity and ototoxicity
Hyperkalemia only
No side effects
Weight loss only
Correct Answer: A
Rationale: Aminoglycosides: nephrotoxic (monitor creatinine), ototoxic (hearing loss, tinnitus), check peak/trough.
[19] Long-term steroid teaching?
, Take with food in AM, do not stop abruptly, monitor blood sugar
Take on empty stomach at night
Stop suddenly
No need to monitor
Correct Answer: A
Rationale: Steroids: take AM with food, taper, increase infection risk, hyperglycemia, weight gain, osteoporosis, GI bleed.
[20] Foods high in Vitamin K?
Green leafy vegetables: spinach, kale, broccoli
Apples
Rice
Chicken
Correct Answer: A
Rationale: Vitamin K reverses warfarin. Keep intake consistent, not avoid, but consistent.
[21] Opioid overdose triad?
Respiratory depression, pinpoint pupils, decreased LOC
Tachycardia, hypertension
Dilated pupils
Agitation
Correct Answer: A
Rationale: Opioid overdose: respiratory depression, pinpoint pupils, CNS depression. Antidote naloxone.
[22] Gentamicin side effect?
Nephrotoxicity and ototoxicity
Hyperkalemia only
No side effects
Weight loss only
Correct Answer: A
Rationale: Aminoglycosides: nephrotoxic (monitor creatinine), ototoxic (hearing loss, tinnitus), check peak/trough.
[23] Long-term steroid teaching?
Take with food in AM, do not stop abruptly, monitor blood sugar
Take on empty stomach at night
Stop suddenly
No need to monitor
Correct Answer: A
Rationale: Steroids: take AM with food, taper, increase infection risk, hyperglycemia, weight gain, osteoporosis, GI bleed.
[24] Foods high in Vitamin K?
Green leafy vegetables: spinach, kale, broccoli
Apples
Rice
Chicken
Correct Answer: A
Rationale: Vitamin K reverses warfarin. Keep intake consistent, not avoid, but consistent.
[25] Opioid overdose triad?
Respiratory depression, pinpoint pupils, decreased LOC
Tachycardia, hypertension
Dilated pupils
Agitation
