Pharmacotherapeutics For Advanced
Practice Nurse Prescribersquestions
With Correct Answers & Complete
Solutions | Graded A+
Nurseypractitioneryprescriptiveyauthorityyisyregulatedybyywho?y-
yTheyStateyBoardyofyNursingyforyEachyState
WhatyisytheybenefitsyofyhavingyanyAPRNyprescriber?y-
yAPRN'sycareyforypatientsymoreyholisticallyyandyincludeypatientsyinymakingydecisi
onsyregardingytheirycare
Whatydoesyclinicalyjudgementyinyprescribingyinclude?y-
yFactoringyinytheycostyofytheyparticular
Whatyisyincludedyinytheycriteriayforychoosingyandyeffectiveydrugyforyaydisorder?
y-yConsultingynationallyyrecognizedyguidelinesyforydiseaseymanagement
NP'sythriveyunderytheynewyhealth-careyreformybecauseyofywhat?y-
yNP'syhaveytheyabilityytoycontrolycareycostyandyimproveypatientyoutcome
Nutritionalyintakeyandylabyresultsyreflectyhypoalbuminemia;ywhyyisythisyimportantyf
oryprescribers?y-yTheyDistributionyofydrugsytoytargetytissuesymayybeyaffected
Drugsythatyhaveyanysignificantyfirst-passyeffectywhat?y-
ytheyyareyrapidlyymetabolizedybyytheyliveryandymayyhaveylittleyifyanyydesiredyac
tion
Theyrouteyofyexcretionyofyayvolatileydrugywillylikelyybe?y-yLungs
Medroxyprogesteroney(DepoyProvera)yisyprescribedyIMytoycreateystorageyreservoir
yofytheydrug.yWhatyareystorageyreserviors>y-
yIncreasedytheylengthyofytimeyaydrugyisyavailableyandyactive
WhyyisyCephalexinygivenyeveryy8yhours?
yWhatyknowledgeyofytheydrugydoesytheyNPyknow?y-yHalfyLife
, Azithromycinydoingyrequiresythatytheyfirstyday'sydoingybeytwiceythoseyofytheyothe
ryfouryday;yThisyisyconsideredyayloadingydoes.yWhatyisyayloadingydose?y-
yRapidlyyactivesydrugylevelsyinytheytherapeuticyrange
Theypointyinytimeyonytheydrugyconcentrationycurveythatyindicatesytheyfirstysignyo
fyaytherapeuticyeffectyisythe:y-yOnsetyofyaction
Phenytoinyrequiredythatyaytroughylevelybeydrawn.yWhenyandywhyyareypeakyandy
troughylevelsyareydoney-yToydetermineyifyaydyrugyisyinytheytherapeuticyrange
Drugsythatyareyreceptoryagonistsymayydemonstrateywhatyproperty?y-
yConcentrationsywillyproduceyanyadverseyeffect
Factorsythatyaffectygastricydrugyabsorptionyincludey-yLipidysolubilityyofytheydrug
Drugsythatyareyreceptorsyantagonists,ysuchyasybeta-blockers,ymayycauseywhat?y-
yAnyexaggeratedyresponseyifyabruptydiscontinues
DrugyadministrationyviayIV:
1)yneedytoybeylipidysolubleyinyorderytoyabsorbyeasily
2)yBeginydistributionyinytheybodyyimmediately
3)yAreyeasilyyabsorbedyifytheyyareynonionized
4)yMayyuseypinocytosisytoybeyabsorbedy-
yAreyeasilyyabsorbedyifytheyyareynonionized
Whatyisytheycombinationyeffectywhenyaymedicationyisyaddedytoyayregimenyforya
ysynergisticyeffect?y-
yGreaterythanytheysumyofytheyeffectsyofyeachydrugyindividually
Whichyofytheyfollowingystatementsyaboutybioavailabilityyisytrue?
1)yBioavailabilityyissuesyareyespeciallyyimportantyforydrugsywithynarrowytherapeuti
c
rangesyorysustained-releaseymechanisms.
2)ybrandsyofyaydrugyhaveytheysameybioavailability.
3)yDrugsythatyareyadministeredymoreythanyonceyaydayyhaveygreaterybioavailabilit
yythan
drugsygivenyonceydaily.
4)yCombiningyanyactiveydrugywithyanyinertysubstanceydoesynotyaffectybioavailabil
ity.y-
yBioavailabilityyissuesyareyespeciallyyimportantyforydrugsywithynarrowytherapeutic
Whichyofytheyfollowingystatementsyaboutytheymajorydistributionybarriersy(blood-
brainyoryfetal-placental)yisytrue?
1)yWaterysolubleyandyionizedydrugsycrossytheseybarriersyrapidly.
Practice Nurse Prescribersquestions
With Correct Answers & Complete
Solutions | Graded A+
Nurseypractitioneryprescriptiveyauthorityyisyregulatedybyywho?y-
yTheyStateyBoardyofyNursingyforyEachyState
WhatyisytheybenefitsyofyhavingyanyAPRNyprescriber?y-
yAPRN'sycareyforypatientsymoreyholisticallyyandyincludeypatientsyinymakingydecisi
onsyregardingytheirycare
Whatydoesyclinicalyjudgementyinyprescribingyinclude?y-
yFactoringyinytheycostyofytheyparticular
Whatyisyincludedyinytheycriteriayforychoosingyandyeffectiveydrugyforyaydisorder?
y-yConsultingynationallyyrecognizedyguidelinesyforydiseaseymanagement
NP'sythriveyunderytheynewyhealth-careyreformybecauseyofywhat?y-
yNP'syhaveytheyabilityytoycontrolycareycostyandyimproveypatientyoutcome
Nutritionalyintakeyandylabyresultsyreflectyhypoalbuminemia;ywhyyisythisyimportantyf
oryprescribers?y-yTheyDistributionyofydrugsytoytargetytissuesymayybeyaffected
Drugsythatyhaveyanysignificantyfirst-passyeffectywhat?y-
ytheyyareyrapidlyymetabolizedybyytheyliveryandymayyhaveylittleyifyanyydesiredyac
tion
Theyrouteyofyexcretionyofyayvolatileydrugywillylikelyybe?y-yLungs
Medroxyprogesteroney(DepoyProvera)yisyprescribedyIMytoycreateystorageyreservoir
yofytheydrug.yWhatyareystorageyreserviors>y-
yIncreasedytheylengthyofytimeyaydrugyisyavailableyandyactive
WhyyisyCephalexinygivenyeveryy8yhours?
yWhatyknowledgeyofytheydrugydoesytheyNPyknow?y-yHalfyLife
, Azithromycinydoingyrequiresythatytheyfirstyday'sydoingybeytwiceythoseyofytheyothe
ryfouryday;yThisyisyconsideredyayloadingydoes.yWhatyisyayloadingydose?y-
yRapidlyyactivesydrugylevelsyinytheytherapeuticyrange
Theypointyinytimeyonytheydrugyconcentrationycurveythatyindicatesytheyfirstysignyo
fyaytherapeuticyeffectyisythe:y-yOnsetyofyaction
Phenytoinyrequiredythatyaytroughylevelybeydrawn.yWhenyandywhyyareypeakyandy
troughylevelsyareydoney-yToydetermineyifyaydyrugyisyinytheytherapeuticyrange
Drugsythatyareyreceptoryagonistsymayydemonstrateywhatyproperty?y-
yConcentrationsywillyproduceyanyadverseyeffect
Factorsythatyaffectygastricydrugyabsorptionyincludey-yLipidysolubilityyofytheydrug
Drugsythatyareyreceptorsyantagonists,ysuchyasybeta-blockers,ymayycauseywhat?y-
yAnyexaggeratedyresponseyifyabruptydiscontinues
DrugyadministrationyviayIV:
1)yneedytoybeylipidysolubleyinyorderytoyabsorbyeasily
2)yBeginydistributionyinytheybodyyimmediately
3)yAreyeasilyyabsorbedyifytheyyareynonionized
4)yMayyuseypinocytosisytoybeyabsorbedy-
yAreyeasilyyabsorbedyifytheyyareynonionized
Whatyisytheycombinationyeffectywhenyaymedicationyisyaddedytoyayregimenyforya
ysynergisticyeffect?y-
yGreaterythanytheysumyofytheyeffectsyofyeachydrugyindividually
Whichyofytheyfollowingystatementsyaboutybioavailabilityyisytrue?
1)yBioavailabilityyissuesyareyespeciallyyimportantyforydrugsywithynarrowytherapeuti
c
rangesyorysustained-releaseymechanisms.
2)ybrandsyofyaydrugyhaveytheysameybioavailability.
3)yDrugsythatyareyadministeredymoreythanyonceyaydayyhaveygreaterybioavailabilit
yythan
drugsygivenyonceydaily.
4)yCombiningyanyactiveydrugywithyanyinertysubstanceydoesynotyaffectybioavailabil
ity.y-
yBioavailabilityyissuesyareyespeciallyyimportantyforydrugsywithynarrowytherapeutic
Whichyofytheyfollowingystatementsyaboutytheymajorydistributionybarriersy(blood-
brainyoryfetal-placental)yisytrue?
1)yWaterysolubleyandyionizedydrugsycrossytheseybarriersyrapidly.