NSG 5003 WEEK 6 KNOWLEDGE CHECK
QUESTRIONS WITH COMPLETE
SOLUTION GUARANTEED SUCCESS.
1. Which hormone, produced by the kidneys, is the primary regulator of erythropoiesis in
response to hypoxia?
A. Thrombopoietin
B. Erythropoietin
C. Interleukin-3
D. Aldosterone
Answer: B
Conceptual Explanation: Erythropoietin is synthesized by the peritubular cells of the
kidney in response to low oxygen levels to stimulate red blood cell production.
2. In Iron Deficiency Anemia, how would you typically describe the morphology of the red
blood cells?
A. Macrocytic and Normochromic
B. Normocytic and Normochromic
C. Microcytic and Hypochromic
D. Microcytic and Hyperchromic
,Answer: C
Conceptual Explanation: Iron deficiency leads to smaller cells (microcytic) with reduced
hemoglobin content (hypochromic).
3. Pernicious anemia is caused by a deficiency in which of the following, leading to impaired
Vitamin B12 absorption?
A. Ferritin
B. Transferrin
C. Intrinsic Factor
D. Transcobalamin II
Answer: C
Conceptual Explanation: Intrinsic factor, secreted by gastric parietal cells, is essential for
the absorption of Vitamin B12 in the ileum.
4. Which clinical finding is unique to Vitamin B12 deficiency compared to folate deficiency?
A. Glossitis
B. Fatigue
C. Stomatitis
D. Demyelination leading to neurological symptoms
Answer: D
, Conceptual Explanation: Vitamin B12 is essential for myelin synthesis; its deficiency
causes subacute combined degeneration of the spinal cord, which folate deficiency does
not.
5. What is the underlying genetic defect in Sickle Cell Anemia?
A. Deletion of the alpha-globin gene
B. Translocation between chromosomes 9 and 22
C. A point mutation where valine replaces glutamic acid
D. Mutation in the JAK2 signaling protein
Answer: C
Conceptual Explanation: Sickle cell disease results from a single amino acid substitution
(valine for glutamic acid) in the beta-globin chain.
6. Which diagnostic marker is hallmark for Chronic Myeloid Leukemia (CML)?
A. Reed-Sternberg cells
B. Philadelphia Chromosome (t[9;22])
C. Bence-Jones proteins
D. Auer rods
Answer: B
Conceptual Explanation: The Philadelphia chromosome, involving the BCR-ABL1 fusion
gene, is the pathognomonic marker for CML.
QUESTRIONS WITH COMPLETE
SOLUTION GUARANTEED SUCCESS.
1. Which hormone, produced by the kidneys, is the primary regulator of erythropoiesis in
response to hypoxia?
A. Thrombopoietin
B. Erythropoietin
C. Interleukin-3
D. Aldosterone
Answer: B
Conceptual Explanation: Erythropoietin is synthesized by the peritubular cells of the
kidney in response to low oxygen levels to stimulate red blood cell production.
2. In Iron Deficiency Anemia, how would you typically describe the morphology of the red
blood cells?
A. Macrocytic and Normochromic
B. Normocytic and Normochromic
C. Microcytic and Hypochromic
D. Microcytic and Hyperchromic
,Answer: C
Conceptual Explanation: Iron deficiency leads to smaller cells (microcytic) with reduced
hemoglobin content (hypochromic).
3. Pernicious anemia is caused by a deficiency in which of the following, leading to impaired
Vitamin B12 absorption?
A. Ferritin
B. Transferrin
C. Intrinsic Factor
D. Transcobalamin II
Answer: C
Conceptual Explanation: Intrinsic factor, secreted by gastric parietal cells, is essential for
the absorption of Vitamin B12 in the ileum.
4. Which clinical finding is unique to Vitamin B12 deficiency compared to folate deficiency?
A. Glossitis
B. Fatigue
C. Stomatitis
D. Demyelination leading to neurological symptoms
Answer: D
, Conceptual Explanation: Vitamin B12 is essential for myelin synthesis; its deficiency
causes subacute combined degeneration of the spinal cord, which folate deficiency does
not.
5. What is the underlying genetic defect in Sickle Cell Anemia?
A. Deletion of the alpha-globin gene
B. Translocation between chromosomes 9 and 22
C. A point mutation where valine replaces glutamic acid
D. Mutation in the JAK2 signaling protein
Answer: C
Conceptual Explanation: Sickle cell disease results from a single amino acid substitution
(valine for glutamic acid) in the beta-globin chain.
6. Which diagnostic marker is hallmark for Chronic Myeloid Leukemia (CML)?
A. Reed-Sternberg cells
B. Philadelphia Chromosome (t[9;22])
C. Bence-Jones proteins
D. Auer rods
Answer: B
Conceptual Explanation: The Philadelphia chromosome, involving the BCR-ABL1 fusion
gene, is the pathognomonic marker for CML.
