NSG 5003 WEEK 4 KNOWLEDGE CHECK
QUESTRIONS WITH COMPLETE
SOLUTION GUARANTEED SUCCESS.
1. Which of the following is the hallmark laboratory finding in Pernicious Anemia?
A. Low serum iron levels
B. Microcytic, hypochromic red blood cells
C. Presence of anti-intrinsic factor antibodies
D. Elevated serum ferritin levels
Answer: C
Conceptual Explanation: Pernicious anemia is an autoimmune condition where the body
lacks intrinsic factor due to antibodies against parietal cells or the factor itself, leading to
B12 malabsorption.
2. In the context of Disseminated Intravascular Coagulation (DIC), what is the primary cause
of widespread bleeding?
A. Hyperactivity of the coagulation cascade
B. Depletion of clotting factors and platelets
C. Excessive production of Vitamin K
D. Inherited deficiency of Factor VIII
,Answer: B
Conceptual Explanation: DIC involves systemic activation of coagulation which consumes
clotting factors and platelets, eventually leading to severe hemorrhage.
3. Which cell type is pathognomonic for Hodgkin Lymphoma?
A. Bence-Jones cells
B. Auer rods
C. Smudge cells
D. Reed-Sternberg cells
Answer: D
Conceptual Explanation: Reed-Sternberg cells are large, multi-nucleated B cells (‘owl-eye’
appearance) characteristic of Hodgkin Lymphoma.
4. Which hypersensitivity reaction is mediated by IgE and involves mast cell degranulation?
A. Type I
B. Type II
C. Type III
D. Type IV
Answer: A
, Conceptual Explanation: Type I hypersensitivity is immediate and mediated by IgE
antibodies binding to mast cells, triggering the release of histamine.
5. A patient presents with a Mean Corpuscular Volume (MCV) of 72 fL. Which diagnosis is
most likely?
A. Folate deficiency anemia
B. Vitamin B12 deficiency
C. Iron deficiency anemia
D. Aplastic anemia
Answer: C
Conceptual Explanation: An MCV below 80 fL indicates microcytic anemia, commonly
caused by iron deficiency.
6. What is the primary pathophysiology of Sickle Cell Anemia?
A. Deficiency in the synthesis of heme
B. Autoimmune destruction of red blood cells
C. A genetic mutation causing a single amino acid substitution in the beta-globin chain
D. Chronic blood loss through the GI tract
Answer: C
Conceptual Explanation: Sickle cell anemia is caused by a point mutation (valine for
glutamic acid) in the beta-globin chain of hemoglobin.
QUESTRIONS WITH COMPLETE
SOLUTION GUARANTEED SUCCESS.
1. Which of the following is the hallmark laboratory finding in Pernicious Anemia?
A. Low serum iron levels
B. Microcytic, hypochromic red blood cells
C. Presence of anti-intrinsic factor antibodies
D. Elevated serum ferritin levels
Answer: C
Conceptual Explanation: Pernicious anemia is an autoimmune condition where the body
lacks intrinsic factor due to antibodies against parietal cells or the factor itself, leading to
B12 malabsorption.
2. In the context of Disseminated Intravascular Coagulation (DIC), what is the primary cause
of widespread bleeding?
A. Hyperactivity of the coagulation cascade
B. Depletion of clotting factors and platelets
C. Excessive production of Vitamin K
D. Inherited deficiency of Factor VIII
,Answer: B
Conceptual Explanation: DIC involves systemic activation of coagulation which consumes
clotting factors and platelets, eventually leading to severe hemorrhage.
3. Which cell type is pathognomonic for Hodgkin Lymphoma?
A. Bence-Jones cells
B. Auer rods
C. Smudge cells
D. Reed-Sternberg cells
Answer: D
Conceptual Explanation: Reed-Sternberg cells are large, multi-nucleated B cells (‘owl-eye’
appearance) characteristic of Hodgkin Lymphoma.
4. Which hypersensitivity reaction is mediated by IgE and involves mast cell degranulation?
A. Type I
B. Type II
C. Type III
D. Type IV
Answer: A
, Conceptual Explanation: Type I hypersensitivity is immediate and mediated by IgE
antibodies binding to mast cells, triggering the release of histamine.
5. A patient presents with a Mean Corpuscular Volume (MCV) of 72 fL. Which diagnosis is
most likely?
A. Folate deficiency anemia
B. Vitamin B12 deficiency
C. Iron deficiency anemia
D. Aplastic anemia
Answer: C
Conceptual Explanation: An MCV below 80 fL indicates microcytic anemia, commonly
caused by iron deficiency.
6. What is the primary pathophysiology of Sickle Cell Anemia?
A. Deficiency in the synthesis of heme
B. Autoimmune destruction of red blood cells
C. A genetic mutation causing a single amino acid substitution in the beta-globin chain
D. Chronic blood loss through the GI tract
Answer: C
Conceptual Explanation: Sickle cell anemia is caused by a point mutation (valine for
glutamic acid) in the beta-globin chain of hemoglobin.
