Top 500 Drugs CPJE Exam | Questions & Verified Answers

Top 500 drugs CPJE LATEST UPDATES!!!
2026-2027 | CORRECT SOLUTIONS WITH
comprehensive questions and
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Acetazolamide - CORRECT ANSWERS-Diamox
MOA- Carbonic Anhydrase Inhibitor
sun protection and hydration are recommended
- for Altitude sickness and motion sickness --> 125 mg BID
- CI: sulfa allergy

Sevelamer - CORRECT ANSWERS-- Renvela (carbonate) or Renagel (HCl)
- CI: Bowel obstruction
- Indication: hyperphosphatemia in CKD
- non-Ca, Non-Al based phosphate binder
- lower TC and LDL by 15%-30%
- Sevelamer carbonate maintains Bicarbonate concentrations
- SE: NVD (>20%)
- 800- 1,600 mg TID w/ meals

Calcitrol (Rocaltrol)- Cap, Sol'n, Injection
Calcifediol (Rayaldee ER) - CORRECT ANSWERS-- Vitamin D analogs
- increase intestinal absorption of Ca and provide a negative feedback to parathyroid
gland
- CI: hypercalcemia, vitamin D toxicity
- Indication: Dialysis, Vitamin D deficiency and secondary hyperparathyroidism in CKD
- Dose for Calcitriol
------ CKD: 0.25-0.5 mcg PO daily
------Dialysis: 0.5-1 mcg PO daily of 0.5-4 mcg IV 3X weekly

Vitamin D - CORRECT ANSWERS-Vitamin D3--> Rocaltrol calcitriol
Vitamin D2--> Drisdol ergocalciferol

Cinacalcet - CORRECT ANSWERS-Sensipar
Dialysis: 30-180 mg PO QD w/ food
CI: Hypocalcemia
MOA: calcimimetic --> lowers PTH, Ca, PO4
SE: hypocalcemia

Penicillin - CORRECT ANSWERS-Pen VK

,- take on empty stomach
- tablet, suspension

Penicillin G Benzathine - CORRECT ANSWERS-Bicillin L-A
BBW: not for IV use --> can cause cardiorespiratory arrest and death
Indication: Syphillis

Amoxicillin - CORRECT ANSWERS-Amoxil, Moxatag
- Tablet, Capsule, Chewable, suspension

Amoxicillin + Clavulanate - CORRECT ANSWERS-Augmentin
- CI: hx of cholestatic jaundice or hepatic dysfunction assosicated w/ previous use,
Severe renal Impairment CrCl <30 mL/min

- Tablet, chewable, suspension

Cephalexin - CORRECT ANSWERS-Keflex (PO)
1st generation: Skin infections MSSA, strep throat

Cefuroxime - CORRECT ANSWERS-Ceftin, Zinacef ----2nd generation
Common uses: otitis media, CAP, Sinus Infection
*** in sulfa allergy in children--> Ceftin is acceptable alternative for otitis media

Cefotetan (Cefotan) and cefoxitin - CORRECT ANSWERS-anaerobe coverage (B.
fragilis)
****Cefotetan can cause disulfiram like reaction w/ alcohol ingestion
----- 1-2 g IV/IM Q12H

recommended antibiotics for prophylaxis before colorectal surgeries

Ceftriaxone - CORRECT ANSWERS-Rocephin
3rd generation
no renal adjustment
once daily dosing
- do not use in neonates (0-28 days)
- Common uses: CAP, meningitis, SBP, Pyelonephritis

*** Cefotaxime is another 3rd generation cephalosporin

Ceftaroline - CORRECT ANSWERS-Teflaro (5th gen cephalosporin)
**** The only B-lactam that is active against MRSA

Cefazolin (IV) - CORRECT ANSWERS-Ancef, Kefzol
- 1st generation ceph
- surgical prophylaxis

,Ertapenem - CORRECT ANSWERS-Invanz
- it is dosed once daily IV/IM
- Stable in NS only
common uses: ESBL-producing bacteria, DFI
**** No pseudomonas, acinetobacter or enterococcus

Fluoroquinolones - CORRECT ANSWERS-BBW: CNS effects (Seizures hx), Tendonitis,
peripheral neuropathy
- may exacerbate muscle weakness related to myasthenia gravis
**** may use if no other alternative available for uncomplicated UTI, bacterial sinusitis,
chronic bronchitis

***Moxifloxcin --> do not use in UTI, highest risk for QT prolongation

Ciprofloxacin - CORRECT ANSWERS-Cipro, Ciloxin eye drops, ciprodex ear drops
(+dexamethasone), Otovel ear drops ( + fluocinolone)
Cetraxal sol'n--- Ciprofloxacin for acute otitis externa (swimmer's ear)

- oil based suspension ---> should not be given through NG or other feeding tube--->
crush IR tabs, mix w/ water and give via feeding tube. hold tube feedings at least 1hr
before and 2 hrs after dose- shake vigorously for 15 seconds before use

-250-750 mg PO Q8-12 hrs
- 200-400 mg IV Q 8-12 hrs

Ofloxacin - CORRECT ANSWERS-Ocuflox, Floxin Otic

IV: PO - CORRECT ANSWERS-minocycline, doxycycline 1:1
moxifloxacin, levofloxacin 1:1
*** Tetracycline--> No IV

Metronidazole - CORRECT ANSWERS-Flagyl
- Mild-moderate CDI: 500 mg IV/PO TID for 10-14 days
- no renal adjustment
- take IR tabs w/ food***
- Take ER tabs on empty stomach
- metallic taste---No alcohol 3 days after discontinuation
- Indication: bacterial vaginosis, trichomoniasis, giardiasis, amebiasis, C. Difficile, intra-
abdominal infections.
-----Does not cover UTI, CAP
***CI: 1st trimester in pregnancy (except for trichomoniasis)


**** Tinidazole (Tindamax) limited to protozoa (giardiasis, amebiasis), trichomoniasis,
bacterial vaginosis organisms.

, Fosfomycin - CORRECT ANSWERS-Monurol
Urinary antiinfective
used in females only
3g X1 mixed w/ 3-4 oz of water

Rifaximin (Xifaxan) - CORRECT ANSWERS-- TD-- 200mg PO TID X 3days
- hepatic encephalopathy recurrence 550mg PO BID

- IBS -D 550 mg PO TID x 14 days

Pseudomonas aeruginosa coverage - CORRECT ANSWERS-Zosyn
cefepime (Maxipime)
ceftazidime (Fortaz, Tazicef)
ceftazidime/avibactam (Avycaz)
ceftolozane/Tazobactam (Zerbaxa)
Carbapenems (except ertapenem)
Ciprofloxacin, Levofloxacin
Aztreonam (Azactam)
AGs
Colistimethate, Polymyxin B

Carbapenem-resistant Enterobacteriaceae (CRE) - CORRECT ANSWERS-
Ceftazidime/Avibactam
Colistimethate, Polymyxin B

B. fragilis - CORRECT ANSWERS-Metronidazole
Beta-lactam/beta lactamase inhibitor
cefotetan, Cefoxitin
carbapenems
Tigecycline

Acute bacterial meningitis tx - CORRECT ANSWERS-- dexamethasone is given 15-20
min prior to or w/ 1st dose of Abx to prevent neurological complications of meningitis.
- Dexamethasone dose : 0.15 mg/kg IV Q6H x4day
-----3 drug options, Ampicilin, Vanco and ceftriaxone
if severe PCN allergy --> Quinolone (moxifloxacin or levofloxacin) + vancomycin
+/- bactrim 10-20 mg/kg day IV divided Q6-12 hrs for listeria coverage

*** bactrim for ampicilin
**** FQ for ceftriaxone

Acute Otitis Media (AOM) - CORRECT ANSWERS-1st line: amoxicillin or Augmentin

Alternative if PCN allergy --> Cefdinir or cefuroxime, ceftriaxone

TB - CORRECT ANSWERS-Active TB