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ACLS Final Exam 2026/2027 Complete Verified Guide
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INTRODUCTION
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Guide Graded A+ 100% Verified Pass Guaranteed LATEST!!!.
Every item uses a focused exam stem, four response options, a
keyed response, and a clear rationale, making it easier to
understand the subject, spot distractors, and build real exam
confidence.
Page 1
, Question 1
A patient in cardiac arrest with refractory VF has received three shocks,
epinephrine, and amiodarone. End-tidal CO2 abruptly rises from 10 to 45
mmHg. What is the most likely explanation and immediate priority?
A. Return of spontaneous circulation; check pulse and proceed to
post-arrest care.
B. Endotracheal tube dislodgement; reassess airway and ventilate with
bag-mask.
C. Effective chest compressions; continue CPR for 2 minutes before
rhythm check.
D. Metabolic alkalosis from excessive ventilation; reduce ventilation rate.
Correct Answer: A - Return of spontaneous circulation; check
pulse and proceed to post-arrest care.
RATIONALE
A sudden sustained rise in ETCO2 >40 mmHg during CPR indicates a
significant increase in pulmonary blood flow, most consistent with
ROSC. The immediate priority is to check for a pulse and, if present,
initiate post-cardiac arrest care. Tube dislodgement would cause a
decrease, not increase, in ETCO2; effective compressions typically
produce ETCO2 10-20 mmHg; alkalosis does not cause abrupt
ETCO2 rise.
Question 2
Which vasopressor and dose is recommended for a patient with symptomatic
bradycardia unresponsive to atropine, according to the 2025 AHA ACLS
guidelines?
A. Dopamine infusion 5-20 mcg/kg/min
B. Epinephrine infusion 2-10 mcg/min
C. Norepinephrine infusion 0.05-0.5 mcg/kg/min
D. Phenylephrine infusion 40-200 mcg/min
Page 2
,Correct Answer: B - Epinephrine infusion 2-10 mcg/min
RATIONALE
The 2025 AHA guidelines recommend epinephrine infusion (2-10
mcg/min) as the first-line vasopressor for symptomatic bradycardia
unresponsive to atropine. Dopamine is no longer preferred due to
arrhythmogenicity and evidence of harm. Norepinephrine and
phenylephrine are not first-line for bradycardia because they lack
beta-1 chronotropic effects.
Question 3
A patient with a wide-complex tachycardia is stable but has a history of heart
failure with reduced ejection fraction. Which antiarrhythmic is most
appropriate for chemical conversion?
A. Adenosine 6 mg rapid IV push
B. Amiodarone 150 mg IV over 10 minutes
C. Procainamide 20-50 mg/min until arrhythmia resolves
D. Sotalol 100 mg IV over 5 minutes
Correct Answer: B - Amiodarone 150 mg IV over 10 minutes
RATIONALE
For stable wide-complex tachycardia, amiodarone is preferred,
especially in patients with structural heart disease or heart failure.
Adenosine is ineffective for most ventricular tachycardias and may
cause hypotension. Procainamide and sotalol are contraindicated in
heart failure due to negative inotropic effects and proarrhythmia risk.
Question 4
During a resuscitation, the team leader notes that compressions are too shallow.
Which real-time feedback parameter best correlates with adequate compression
depth?
A. End-tidal CO2 >10 mmHg
Page 3
, B. Diastolic blood pressure >20 mmHg
C. Central venous oxygen saturation >70%
D. Peak systolic pressure >80 mmHg
Correct Answer: A - End-tidal CO2 >10 mmHg
RATIONALE
ETCO2 >10 mmHg is a validated surrogate for adequate pulmonary
blood flow during CPR, reflecting compression depth and rate.
Diastolic blood pressure and systolic pressure are not routinely used
for real-time feedback. Central venous oxygen saturation is not a
real-time compression quality metric.
Question 5
A patient with ROSC after cardiac arrest remains comatose. Which
intervention has the strongest evidence for improving neurological outcome?
A. Prophylactic antibiotics
B. Targeted temperature management (32-36°C) for at least 24 hours
C. Immediate coronary angiography regardless of ECG
D. Hyperventilation to maintain PaCO2 25-30 mmHg
Correct Answer: B - Targeted temperature management
(32-36°C) for at least 24 hours
RATIONALE
Targeted temperature management (TTM) at 32-36°C for at least 24
hours is a Class I recommendation for comatose post-arrest patients,
with strong evidence for improved neurological outcomes.
Prophylactic antibiotics are not routine; immediate angiography is
indicated for STEMI but not universally; hyperventilation causes
cerebral vasoconstriction and is harmful.
Page 4