NUR 600 Exam 1 | (2026) Pharmacology
Questions | Clinical Nursing (PDF)
1. A patient with cirrhosis has decreased metabolism of a
prodrug. What pharmacokinetic change is expected?
A. Increased active drug concentration
B. Decreased active drug concentration
C. No change in drug levels
D. Faster renal excretion
Answer: B
Rationale: A prodrug requires hepatic metabolism to
1
,become active. Cirrhosis reduces metabolism, leading
to decreased active drug concentration.
2. A drug has a half-life of 4 hours. How many hours to
reach steady state?
A. 8 hours
B. 12 hours
C. 20 hours
D. 32 hours
Answer: C
2
,Rationale: Steady state occurs after 4–5 half-lives → 4 ×
5 = 20 hours.
3. Which factor increases volume of distribution (Vd)?
A. High protein binding
B. High lipophilicity
C. Low tissue binding
D. Large molecular size
Answer: B
Rationale: Lipophilic drugs distribute into fatty tissues,
increasing Vd.
3
, 4. A medication follows first-order kinetics. Doubling the
dose will:
A. Double half-life
B. Proportionally increase steady-state concentration
C. Prolong time to steady state
D. Increase clearance
Answer: B
Rationale: In first-order kinetics, steady-state
concentration increases proportionally to dose.
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Questions | Clinical Nursing (PDF)
1. A patient with cirrhosis has decreased metabolism of a
prodrug. What pharmacokinetic change is expected?
A. Increased active drug concentration
B. Decreased active drug concentration
C. No change in drug levels
D. Faster renal excretion
Answer: B
Rationale: A prodrug requires hepatic metabolism to
1
,become active. Cirrhosis reduces metabolism, leading
to decreased active drug concentration.
2. A drug has a half-life of 4 hours. How many hours to
reach steady state?
A. 8 hours
B. 12 hours
C. 20 hours
D. 32 hours
Answer: C
2
,Rationale: Steady state occurs after 4–5 half-lives → 4 ×
5 = 20 hours.
3. Which factor increases volume of distribution (Vd)?
A. High protein binding
B. High lipophilicity
C. Low tissue binding
D. Large molecular size
Answer: B
Rationale: Lipophilic drugs distribute into fatty tissues,
increasing Vd.
3
, 4. A medication follows first-order kinetics. Doubling the
dose will:
A. Double half-life
B. Proportionally increase steady-state concentration
C. Prolong time to steady state
D. Increase clearance
Answer: B
Rationale: In first-order kinetics, steady-state
concentration increases proportionally to dose.
4
