Chamberlain NR 507 Advanced Pathophysiology Midterm Exam - Practice Questions & Verified Answers
Hypersensitivity Type 1 is... Allergic Reaction
Hypersensitivity Type 1 is meadiated by IgE
Hypersensitivty type 1: inflammation as result of mast cell degranulation
hypersensitivity type 1 s/s itching/rash
Hypersensitivity Type 1 systemic s/s wheezing
Hypersensitivity type 1 most dangerous form of reaction anaphylactic reaction- systemic response leading to hypotension and severe
bronchoconstriction
Treatment for hypersensitivity type 1 reaction epi pen
Hypersensitivity type 2 is what kind of reaction cytotoxic reaction that is tissue specific ex thyroid tissue
Hypersensitivity type 2 primary effector cells macrophages
Hypersensitivity type 2 can cause damage to tissue or alter function
hypersensitivity type 2 example graves' disease, incompatible blood typing leading to cell/tissue damage.
Hypersensitivity type 2 is organ specific the antibody binds to antigen on cell surface
hypersensitivity type 3 is not organ specific. antibody binds to soluble antigen outside of the cell surface that was
released into the blood or body fluids and the complex is then deposited into
tissues.
Examples of Type 3 sensitivity RA- antibodies/antigen deposited into joints
Systemic Lupus Erythematousu( SLE)
Scope of damage of SLE Facial rash, discoid rash (raised patches, scaling), photosensitivity, oral or
nasopharyngeal ulcers, hematologic disorders like anemia, leukopenia,
thrombocytopenia.
2026-2027 | Stuvia Edition
, Chamberlain NR 507 Advanced Pathophysiology Midterm Exam - Practice Questions & Verified Answers
Autoimmunity can be familial, affected family members may not develop the same disease or may
have different disorders. Both for autoimmune disorders and allergies. Associations
with particular autoimmune disease have been ID for a variety of major
histocompatibility complex (MHC) alleles or non-MHC genes
Alloimmunity Immune system reactions against antigens on the tissues of OTHER members of
same species.
Ex of Alloiummunity Neonatal disease where maternal immune system becomes sensitized against
antigens expressed by fetus
Transplant rejection
Transfusion reaction
Hypersensitivity type 4 is a what response delayed
Hypersensitivity is mediated by T-Cells
Type 2 sensitivity organ rejection involves cytotoxcitiy
T-cells play major role in organ rejection which is what type Type IV and it is T-Cell mediated
of sensitivity and what mediates it
what cells have a direct cytotoxic activity T-Cells
Rash for Type 1 immediate hypersensitivity reactions, atopic dermatitis usually characterized by
widely distributed lesions
Rash for type IV contact dermatitis (delayed hypersensitivity) consists of lesions only at the site of
contact with the allergen ex poison ivy
Treatment for Type IV rash topical corticosteroid
Why wouldn't epinephrine or histamine work for type IV epi is only indicated for anaphylactic reactions and antihistamines act on H1
rash receptors, Type IV does not involve mast cells and H1 receptors.
Primary immunodeficiency is result of single gene defect
primary immunodeficiency ex B-lymphocyte deficiency - one of most severe forms of primary immunodeficiency
2026-2027 | Stuvia Edition
Hypersensitivity Type 1 is... Allergic Reaction
Hypersensitivity Type 1 is meadiated by IgE
Hypersensitivty type 1: inflammation as result of mast cell degranulation
hypersensitivity type 1 s/s itching/rash
Hypersensitivity Type 1 systemic s/s wheezing
Hypersensitivity type 1 most dangerous form of reaction anaphylactic reaction- systemic response leading to hypotension and severe
bronchoconstriction
Treatment for hypersensitivity type 1 reaction epi pen
Hypersensitivity type 2 is what kind of reaction cytotoxic reaction that is tissue specific ex thyroid tissue
Hypersensitivity type 2 primary effector cells macrophages
Hypersensitivity type 2 can cause damage to tissue or alter function
hypersensitivity type 2 example graves' disease, incompatible blood typing leading to cell/tissue damage.
Hypersensitivity type 2 is organ specific the antibody binds to antigen on cell surface
hypersensitivity type 3 is not organ specific. antibody binds to soluble antigen outside of the cell surface that was
released into the blood or body fluids and the complex is then deposited into
tissues.
Examples of Type 3 sensitivity RA- antibodies/antigen deposited into joints
Systemic Lupus Erythematousu( SLE)
Scope of damage of SLE Facial rash, discoid rash (raised patches, scaling), photosensitivity, oral or
nasopharyngeal ulcers, hematologic disorders like anemia, leukopenia,
thrombocytopenia.
2026-2027 | Stuvia Edition
, Chamberlain NR 507 Advanced Pathophysiology Midterm Exam - Practice Questions & Verified Answers
Autoimmunity can be familial, affected family members may not develop the same disease or may
have different disorders. Both for autoimmune disorders and allergies. Associations
with particular autoimmune disease have been ID for a variety of major
histocompatibility complex (MHC) alleles or non-MHC genes
Alloimmunity Immune system reactions against antigens on the tissues of OTHER members of
same species.
Ex of Alloiummunity Neonatal disease where maternal immune system becomes sensitized against
antigens expressed by fetus
Transplant rejection
Transfusion reaction
Hypersensitivity type 4 is a what response delayed
Hypersensitivity is mediated by T-Cells
Type 2 sensitivity organ rejection involves cytotoxcitiy
T-cells play major role in organ rejection which is what type Type IV and it is T-Cell mediated
of sensitivity and what mediates it
what cells have a direct cytotoxic activity T-Cells
Rash for Type 1 immediate hypersensitivity reactions, atopic dermatitis usually characterized by
widely distributed lesions
Rash for type IV contact dermatitis (delayed hypersensitivity) consists of lesions only at the site of
contact with the allergen ex poison ivy
Treatment for Type IV rash topical corticosteroid
Why wouldn't epinephrine or histamine work for type IV epi is only indicated for anaphylactic reactions and antihistamines act on H1
rash receptors, Type IV does not involve mast cells and H1 receptors.
Primary immunodeficiency is result of single gene defect
primary immunodeficiency ex B-lymphocyte deficiency - one of most severe forms of primary immunodeficiency
2026-2027 | Stuvia Edition
