UNIVERSITY OF SOUTH ALABAMA CON NU 327 EXAM 2 STUDY
GUIDE & PRACTICE QUESTIONS 2026/2027
CH. 9 Inflammation & Wound Healing - Correct answer ✔✔ We are all familiar with the redness,
warmth, and swelling associated with inflammation. Inflammation is the body's protective
response to injury and infection. It begins with increased vascular permeability in the affected
areas. Increased vascular permeability and blood flow enable white blood cells and repair cells
to arrive at the site of injury. They are like the first responders at the scene of a medical
emergency. The body releases chemicals that dispatch the white blood cells and platelets to the
site of injury. This is called chemotaxis. Other substances amplify or dampen the inflammatory
response.
The increased capillary permeability allows fluid to increase in tissues, causing swelling. The
fluid may be purulent exudate, called pus, which is fluid containing cells, proteins, and debris.
Or the fluid may be clear transudate, like the fluid inside a blister.
Another part of the inflammatory response is leukocytosis, or elevated levels of white blood
cells in the blood. There are five basic types of white blood cells that eat and destroy foreign
matter and debris.
Inflammation produces a systemic response that includes swollen lymph nodes, fever, pain,
sleepiness, lethargy, anemia, and weight loss. Fever is common in inflammation and infection.
Chemicals called pyrogens reset the hypothalamic temperature center to a high setting, just like
turning up a thermostat in a home. Acute inflammation normally resolves once the injury or
infection is gone. Sometimes, however, the inflammation is ongoing, or chronic. Infections such
as tuberculosis can result in chronic inflammation, as can autoimmune diseases.
Now, let's shift to wounds and wound repair. Labile cells continually divide and replicate, and
thus can repair and replace injured cells. Stable cells, found in the liver and bone, can be
induced to replicate wit
John, age 37, appears at your clinic complaining of pain and soreness in his knee. Several days
prior, John had undergone knee surgery to repair a tear in the medial meniscus.
The surgical laceration is considered a _________________ intention.
primary
, secondary
tertiary - Correct answer ✔✔ primary
In a primary intention, the wound edges are close together and scarring is minimal. In a
secondary intention, the wound is allowed to granulate, and wound care is needed daily. The
wound may be packed with gauze or allowed to drain. In tertiary intention, delayed wound
closure often results in significant scarring.
To reduce pain and swelling, John had been taking an anti-prostaglandin medication. Which
enzyme is involved in the formation of prostaglandins associated with pain and swelling?
Lipooxygenase
Cyclooxygenase-1
Cyclooxygenase-2
Arachidonase - Correct answer ✔✔ Cyclooxygenase-2
Cyclooxygenase- 2 is an enzyme that converts arachidonic acid into prostaglandins. The
prostaglandins formed are associated with inflammation and swelling.
Although John's medication reduces swelling and inflammation, he is complaining that it is
hurting his stomach. Which enzyme is involved with the production of protective prostaglandins
that help maintain the health of the gastric mucosa?
Lipooxygenase
Cyclooxygenase-1
Cyclooxygenase-2
Arachidonase - Correct answer ✔✔ Cyclooxygenase-1
GUIDE & PRACTICE QUESTIONS 2026/2027
CH. 9 Inflammation & Wound Healing - Correct answer ✔✔ We are all familiar with the redness,
warmth, and swelling associated with inflammation. Inflammation is the body's protective
response to injury and infection. It begins with increased vascular permeability in the affected
areas. Increased vascular permeability and blood flow enable white blood cells and repair cells
to arrive at the site of injury. They are like the first responders at the scene of a medical
emergency. The body releases chemicals that dispatch the white blood cells and platelets to the
site of injury. This is called chemotaxis. Other substances amplify or dampen the inflammatory
response.
The increased capillary permeability allows fluid to increase in tissues, causing swelling. The
fluid may be purulent exudate, called pus, which is fluid containing cells, proteins, and debris.
Or the fluid may be clear transudate, like the fluid inside a blister.
Another part of the inflammatory response is leukocytosis, or elevated levels of white blood
cells in the blood. There are five basic types of white blood cells that eat and destroy foreign
matter and debris.
Inflammation produces a systemic response that includes swollen lymph nodes, fever, pain,
sleepiness, lethargy, anemia, and weight loss. Fever is common in inflammation and infection.
Chemicals called pyrogens reset the hypothalamic temperature center to a high setting, just like
turning up a thermostat in a home. Acute inflammation normally resolves once the injury or
infection is gone. Sometimes, however, the inflammation is ongoing, or chronic. Infections such
as tuberculosis can result in chronic inflammation, as can autoimmune diseases.
Now, let's shift to wounds and wound repair. Labile cells continually divide and replicate, and
thus can repair and replace injured cells. Stable cells, found in the liver and bone, can be
induced to replicate wit
John, age 37, appears at your clinic complaining of pain and soreness in his knee. Several days
prior, John had undergone knee surgery to repair a tear in the medial meniscus.
The surgical laceration is considered a _________________ intention.
primary
, secondary
tertiary - Correct answer ✔✔ primary
In a primary intention, the wound edges are close together and scarring is minimal. In a
secondary intention, the wound is allowed to granulate, and wound care is needed daily. The
wound may be packed with gauze or allowed to drain. In tertiary intention, delayed wound
closure often results in significant scarring.
To reduce pain and swelling, John had been taking an anti-prostaglandin medication. Which
enzyme is involved in the formation of prostaglandins associated with pain and swelling?
Lipooxygenase
Cyclooxygenase-1
Cyclooxygenase-2
Arachidonase - Correct answer ✔✔ Cyclooxygenase-2
Cyclooxygenase- 2 is an enzyme that converts arachidonic acid into prostaglandins. The
prostaglandins formed are associated with inflammation and swelling.
Although John's medication reduces swelling and inflammation, he is complaining that it is
hurting his stomach. Which enzyme is involved with the production of protective prostaglandins
that help maintain the health of the gastric mucosa?
Lipooxygenase
Cyclooxygenase-1
Cyclooxygenase-2
Arachidonase - Correct answer ✔✔ Cyclooxygenase-1
