Pathophysiology Practice
Questions | OA Study
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,A 45-year-old woman presents with joint pain and Rheumatoid arthritis
stiffness in her hands and wrists. She reports the
stiffness is worse in the morning and lasts for over an
hour. On exam, there is swelling, tenderness, and a
limited range of motion in the metacarpophalangeal
(MCP) and proximal interphalangeal (PIP) joints
bilaterally. Lab results show positive rheumatoid factor
(RF) and anti-CCP antibodies.
A 35-year-old man with a history of intravenous drug Endocarditis
use presents with fever, chills, and fatigue. On exam, he
has a new systolic murmur and small, painless lesions
on the palms and soles (Janeway lesions). Blood
cultures are positive for Staphylococcus aureus.
A 58-year-old man presents to the emergency Myocaridal Infarction
department with crushing chest pain radiating to his left
arm, shortness of breath, and nausea. He is diaphoretic.
ECG shows ST-segment elevations in leads II, III, and
aVF. Troponin levels are elevated.
A 70-year-old woman is admitted with sepsis from a Type 2 Myocaridal infarction
urinary tract infection. She develops chest discomfort
and shortness of breath. Troponin levels are elevated,
but ECG shows no ST-segment elevations. Coronary
angiography reveals no significant obstructive coronary
artery disease
A 58-year-old man with a history of chronic alcohol use cirrhosis
presents with fatigue, abdominal swelling, and
confusion. Physical exam reveals jaundice, ascites,
spider angiomas, and asterixis. Lab tests show elevated
liver enzymes, low albumin, and an increased INR.
A 62-year-old man with a history of diabetes and End Stage Renal Disease
hypertension presents with fatigue, pruritus, swelling in
his legs, and decreased urine output over several
months. Lab results reveal elevated blood urea nitrogen
(BUN), creatinine, hyperkalemia, metabolic acidosis,
and anemia.
A 30-year-old female presents with an acute onset of Botulism
diplopia, ptosis, dysphagia, and symmetric, flaccid,
descending paralysis. She reports recent ingestion of
improperly canned vegetables. Neurological
examination reveals impaired pupillary light reflexes
with preserved sensory function.
, A 30-year-old male presents with intermittent fever, Malaria
chills, malaise, and progressive jaundice. On
examination, he has pallor, hepatosplenomegaly, and
scleral icterus. Laboratory investigations reveal anemia
with elevated reticulocyte count, increased lactate
dehydrogenase (LDH), elevated indirect bilirubin, and
peripheral blood smear showing intraerythrocytic ring
forms consistent with Plasmodium falciparum infection.
A 55-year-old man presents in late summer with a West Nile Virus
sudden onset of fever, headache, myalgia, and a
maculopapular rash. Over the next few days, he
develops confusion and neck stiffness. Cerebrospinal
fluid (CSF) analysis shows lymphocytic pleocytosis and
elevated protein. MRI of the brain reveals
hyperintensities in the basal ganglia and thalamus.
A 62-year-old diabetic male presents with a 6-month Peripheral Neuropathy
history of numbness, tingling, and burning pain in both
feet. On examination, there is decreased sensation to
pinprick and vibration distally, with diminished ankle
reflexes. Motor strength is preserved. Nerve
conduction studies show reduced conduction velocity
and amplitude in the sensory nerves of the lower limbs
A 25-year-old woman presents with fatigue, pallor, and Aplastic Anemia
recurrent infections. Laboratory studies reveal
pancytopenia with decreased reticulocyte count. Bone
marrow biopsy shows a hypocellular marrow with fatty
infiltration. There is no evidence of abnormal infiltrates
or fibrosis.
A 50-year-old woman presents with severe right upper Cholecystitis
quadrant abdominal pain that radiates to her right
scapula and back. The pain started after a fatty meal
and is associated with nausea and vomiting. She has a
fever of 38.5°C. On exam, Murphy's sign is positive.
Labs show leukocytosis and mildly elevated alkaline
phosphatase. Ultrasound reveals thickening of the
gallbladder wall and gallstones.
A 35-year-old man presents with an expanding Lyme Disease
erythematous rash with central clearing (erythema
migrans) and flu-like symptoms two weeks after hiking
in a wooded area in the northeastern United States. He
reports a recent tick bite. A few days later, he develops
unilateral facial droop consistent with Bell's palsy.