NAPLEX Drug Interactions Questions with Correct Answers (Grade
A+)
Question 1: What are the 2 major types of drug interactions?
Answer: pharmacodynamic and pharmacokinetic
Question 2: pharmacodynamic drug interaction
Answer: changes the effect drugs have on the body
Question 3: Naloxone blocking the effects of morphine is an example of a ___ drug interaction.
Answer: pharmacodynamic
Question 4: pharmacokinetic drug interaction
Answer: changes the effect the body has on the drug; ADME
Question 5: Calcium ions chelating fluoroquinolones is an example of a ___ drug interaction.
Answer: pharmacokinetic (absorption)
Question 6: To prevent reduced absorption, these 4 drug classes should be separated from
antacids/multivitamins/sucralfate/polyvalent cations.
Answer: fluoroquinolones, tetracyclines, levothyroxine, bisphosphonates
Question 7: Which drug classes should be separated from PPIs and H2RAs to prevent reduced
absorption due to increased pH?
Answer: antifungals
Question 8: Probenecid preventing the renal excretion of penicillin is an example of a ___ drug
interaction.
Answer: pharmacokinetic
Question 9: CYP 3A4 metabolizes about ___% of CYP enzyme substrates.
Answer: 34%
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, Question 10: Why is lisdexamfetamine formulated as a prodrug?
Answer: must be activated by enzymatic cleavage - prevents abuse via snorting
Question 11: Why is valacyclovir formulated as a prodrug?
Answer: longer half-life and extended dosing interval compared to acyclovir
Question 12: Capecitabine is a prodrug for -
Answer: fluorouracil
Question 13: Codeine is a prodrug for -
Answer: morphine
Question 14: Colistimethate is a prodrug for -
Answer: colistin
Question 15: Famciclovir is a prodrug for -
Answer: penciclovir
Question 16: Levodopa is a prodrug for -
Answer: dopamine
Question 17: Lisdexamfetamine is a prodrug for -
Answer: dextroamphetamine
Question 18: Prednisone is a prodrug for -
Answer: prednisolone
Question 19: Primidone is a prodrug for -
Answer: phenobarbital
Question 20: Valganciclovir is a prodrug for -
Answer: ganciclovir
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A+)
Question 1: What are the 2 major types of drug interactions?
Answer: pharmacodynamic and pharmacokinetic
Question 2: pharmacodynamic drug interaction
Answer: changes the effect drugs have on the body
Question 3: Naloxone blocking the effects of morphine is an example of a ___ drug interaction.
Answer: pharmacodynamic
Question 4: pharmacokinetic drug interaction
Answer: changes the effect the body has on the drug; ADME
Question 5: Calcium ions chelating fluoroquinolones is an example of a ___ drug interaction.
Answer: pharmacokinetic (absorption)
Question 6: To prevent reduced absorption, these 4 drug classes should be separated from
antacids/multivitamins/sucralfate/polyvalent cations.
Answer: fluoroquinolones, tetracyclines, levothyroxine, bisphosphonates
Question 7: Which drug classes should be separated from PPIs and H2RAs to prevent reduced
absorption due to increased pH?
Answer: antifungals
Question 8: Probenecid preventing the renal excretion of penicillin is an example of a ___ drug
interaction.
Answer: pharmacokinetic
Question 9: CYP 3A4 metabolizes about ___% of CYP enzyme substrates.
Answer: 34%
Page 1
, Question 10: Why is lisdexamfetamine formulated as a prodrug?
Answer: must be activated by enzymatic cleavage - prevents abuse via snorting
Question 11: Why is valacyclovir formulated as a prodrug?
Answer: longer half-life and extended dosing interval compared to acyclovir
Question 12: Capecitabine is a prodrug for -
Answer: fluorouracil
Question 13: Codeine is a prodrug for -
Answer: morphine
Question 14: Colistimethate is a prodrug for -
Answer: colistin
Question 15: Famciclovir is a prodrug for -
Answer: penciclovir
Question 16: Levodopa is a prodrug for -
Answer: dopamine
Question 17: Lisdexamfetamine is a prodrug for -
Answer: dextroamphetamine
Question 18: Prednisone is a prodrug for -
Answer: prednisolone
Question 19: Primidone is a prodrug for -
Answer: phenobarbital
Question 20: Valganciclovir is a prodrug for -
Answer: ganciclovir
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