NAPLEX Dyslipidemia Questions with Correct Answers (Grade A+)
Question 1: What are the functions of cholesterol?
Answer: structural part of cell walls, hormone synthesis, bile acids
Question 2: What are bile acids?
Answer: used to absorb fats and lipid soluble vitamins; produced in the liver -> bile ducts -> small intestine
-> liver (enterohepatic recycling)
Question 3: total cholesterol =
Answer: LDL + HDL + VLDL
Question 4: What is the function of HDL?
Answer: absorbs cholesterol and brings it to the liver for removal (lowers ASCVD risk)
Question 5: lipoprotein A
Answer: variant of LDL that is correlated with ASCVD risk
Question 6: Triglycerides >___ can lead to pancreatitis.
Answer: 500
Question 7: Friedewald equation
Answer: LDL = TC - HDL - (TG/5) - don't use if TG >400
Question 8: What is the goal non-HDL?
Answer: <130
Question 9: What is the goal LDL in general?
Answer: <100
Question 10: What is considered to be very high LDL?
Answer: e190
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, Question 11: What is the goal HDL?
Answer: e40 men, e50 women
Question 12: primary hypercholesterolemia
Answer: familial, genetic hypercholesterolemia; can be heterozygous or homozygous
Question 13: secondary hypercholesterolemia
Answer: acquired, due to poor diet and lack of physical activity
Question 14: What makes up an ASCVD risk score?
Answer: age, race, smoking, TC, HDL, LDL, statin therapy, BP, HTN therapy, DM, aspirin
Question 15: What is considered to be a low ASCVD risk score?
Answer: <7.5% - repeat in 4-6 years
Question 16: When do you not need to calculate an ASCVD risk score?
Answer: clinical ASCVD, T2DM, or LDL e190 - will need a statin regardless
Question 17: When is ASCVD risk considered uncertain?
Answer: 7.5-19.9% - need to consider other factors such as family history of ASCVD, metabolic syndrome,
CKD, preeclampsia, premature menopause, high CRP, CAC
Question 18: coronary artery calcium score
Answer: CAC - used when ASCVD risk is 7.5-19.9%, if e100, initiate statin
Question 19: What are natural products that may treat dyslipidemia?
Answer: red yeast rice, plant stanols, fiber, OTC fish oils
Question 20: What are drugs that can increase LDL and TG?
Answer: diuretics, efavirenz, cyclosporine, tacrolimus, atypical antipsychotics, protease inhibitors
Question 21: What are drugs that can increase LDL only?
Answer: fibrates, fish oils (not Vascepa)
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Question 1: What are the functions of cholesterol?
Answer: structural part of cell walls, hormone synthesis, bile acids
Question 2: What are bile acids?
Answer: used to absorb fats and lipid soluble vitamins; produced in the liver -> bile ducts -> small intestine
-> liver (enterohepatic recycling)
Question 3: total cholesterol =
Answer: LDL + HDL + VLDL
Question 4: What is the function of HDL?
Answer: absorbs cholesterol and brings it to the liver for removal (lowers ASCVD risk)
Question 5: lipoprotein A
Answer: variant of LDL that is correlated with ASCVD risk
Question 6: Triglycerides >___ can lead to pancreatitis.
Answer: 500
Question 7: Friedewald equation
Answer: LDL = TC - HDL - (TG/5) - don't use if TG >400
Question 8: What is the goal non-HDL?
Answer: <130
Question 9: What is the goal LDL in general?
Answer: <100
Question 10: What is considered to be very high LDL?
Answer: e190
Page 1
, Question 11: What is the goal HDL?
Answer: e40 men, e50 women
Question 12: primary hypercholesterolemia
Answer: familial, genetic hypercholesterolemia; can be heterozygous or homozygous
Question 13: secondary hypercholesterolemia
Answer: acquired, due to poor diet and lack of physical activity
Question 14: What makes up an ASCVD risk score?
Answer: age, race, smoking, TC, HDL, LDL, statin therapy, BP, HTN therapy, DM, aspirin
Question 15: What is considered to be a low ASCVD risk score?
Answer: <7.5% - repeat in 4-6 years
Question 16: When do you not need to calculate an ASCVD risk score?
Answer: clinical ASCVD, T2DM, or LDL e190 - will need a statin regardless
Question 17: When is ASCVD risk considered uncertain?
Answer: 7.5-19.9% - need to consider other factors such as family history of ASCVD, metabolic syndrome,
CKD, preeclampsia, premature menopause, high CRP, CAC
Question 18: coronary artery calcium score
Answer: CAC - used when ASCVD risk is 7.5-19.9%, if e100, initiate statin
Question 19: What are natural products that may treat dyslipidemia?
Answer: red yeast rice, plant stanols, fiber, OTC fish oils
Question 20: What are drugs that can increase LDL and TG?
Answer: diuretics, efavirenz, cyclosporine, tacrolimus, atypical antipsychotics, protease inhibitors
Question 21: What are drugs that can increase LDL only?
Answer: fibrates, fish oils (not Vascepa)
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