NAPLEX Drug Allergies & ADRs Questions with Correct Answers
(Grade A+)
Question 1: What drugs are associated with photosensitivity?
Answer: amiodarone, thiazides, loops, methotrexate, retinoids, quinolones, St. John's wort, sulfa drugs,
tacrolimus, tetracyclines, voriconazole
Question 2: What drugs are associated with SJS/TEN/DRESS?
Answer: allopurinol, amoxicillin, ampicillin, carbamazepine, ethosuximide, lamotrigine, nevirapine,
phenytoin, sulfamethoxazole, sulfasalazine, vancomycin
Question 3: adverse drug reactions
Answer: all unintended pharmacologic effects of a drug when used correctly; usually dose-related
Question 4: type A ADR
Answer: predictable, known, dose-dependent
Question 5: Nephrotoxicity with aminoglycosides is an example of a type ___ drug reaction.
Answer: A
Question 6: type B ADR
Answer: unrelated to pharmacologic effect, not dose-dependent, due to patient-specific factors
Question 7: An allergic reaction is an example of a type ___ drug reaction.
Answer: B
Question 8: allergy
Answer: immune-mediated reaction to a drug
Question 9: drug hypersensitivity
Answer: like an allergy, but may not be immune-mediated
Question 10: Vancomycin flushing syndrome is an example of a drug -
Answer: hypersensitivity (not allergy)
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, Question 11: idiosyncratic drug reaction
Answer: due to genetic differences
Question 12: Hemolytic anemia due to G6PD deficiency is an example of a ___ reaction.
Answer: idiosyncratic
Question 13: type 1 allergy
Answer: immediate, IgE-mediated, hives, anaphylaxis
Question 14: type 2 allergy
Answer: delayed (5-8d), antibody-mediated, ex. hemolytic anemia
Question 15: type 3 allergy
Answer: delayed (e1wk), immune complex mediated, ex. serum sickness
Question 16: type 4 allergy
Answer: delayed (e48h), T-cell mediated, ex. SJS
Question 17: SJS is a ___-mediated reaction.
Answer: T-cell
Question 18: drug intolerance
Answer: less serious than an allergy, still avoid if possible because bothers the patient
Question 19: How should you counsel patients taking a drug with risk for photosensitivity?
Answer: use broad spectrum sunscreen (UVA/UVB)
Question 20: thrombotic thrombocytopenic purpura
Answer: TTP - clotting throughout the body caused most commonly by a P2Y12i or sulfamethoxazole
Question 21: How is TTP treated?
Answer: immediately with plasma exchange
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(Grade A+)
Question 1: What drugs are associated with photosensitivity?
Answer: amiodarone, thiazides, loops, methotrexate, retinoids, quinolones, St. John's wort, sulfa drugs,
tacrolimus, tetracyclines, voriconazole
Question 2: What drugs are associated with SJS/TEN/DRESS?
Answer: allopurinol, amoxicillin, ampicillin, carbamazepine, ethosuximide, lamotrigine, nevirapine,
phenytoin, sulfamethoxazole, sulfasalazine, vancomycin
Question 3: adverse drug reactions
Answer: all unintended pharmacologic effects of a drug when used correctly; usually dose-related
Question 4: type A ADR
Answer: predictable, known, dose-dependent
Question 5: Nephrotoxicity with aminoglycosides is an example of a type ___ drug reaction.
Answer: A
Question 6: type B ADR
Answer: unrelated to pharmacologic effect, not dose-dependent, due to patient-specific factors
Question 7: An allergic reaction is an example of a type ___ drug reaction.
Answer: B
Question 8: allergy
Answer: immune-mediated reaction to a drug
Question 9: drug hypersensitivity
Answer: like an allergy, but may not be immune-mediated
Question 10: Vancomycin flushing syndrome is an example of a drug -
Answer: hypersensitivity (not allergy)
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, Question 11: idiosyncratic drug reaction
Answer: due to genetic differences
Question 12: Hemolytic anemia due to G6PD deficiency is an example of a ___ reaction.
Answer: idiosyncratic
Question 13: type 1 allergy
Answer: immediate, IgE-mediated, hives, anaphylaxis
Question 14: type 2 allergy
Answer: delayed (5-8d), antibody-mediated, ex. hemolytic anemia
Question 15: type 3 allergy
Answer: delayed (e1wk), immune complex mediated, ex. serum sickness
Question 16: type 4 allergy
Answer: delayed (e48h), T-cell mediated, ex. SJS
Question 17: SJS is a ___-mediated reaction.
Answer: T-cell
Question 18: drug intolerance
Answer: less serious than an allergy, still avoid if possible because bothers the patient
Question 19: How should you counsel patients taking a drug with risk for photosensitivity?
Answer: use broad spectrum sunscreen (UVA/UVB)
Question 20: thrombotic thrombocytopenic purpura
Answer: TTP - clotting throughout the body caused most commonly by a P2Y12i or sulfamethoxazole
Question 21: How is TTP treated?
Answer: immediately with plasma exchange
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