NAPLEX Inflammatory Bowel Disease Questions with Correct
Answers (Grade A+)
Question 1: symptoms of IBD
Answer: bloody diarrhea, rectal urgency, tenesmus, abdominal pain, fatigue
Question 2: tenesmus
Answer: The feeling that you need to pass stools, even though your bowels are already empty
Question 3: What are common triggers of IBD flares?
Answer: infection, NSAIDs, certain foods
Question 4: ulcerative colitis
Answer: confined to rectum and colon, superficial ulcerations; distal disease in descending colon and
rectum only
Question 5: fulminant UC
Answer: >10 bloody stools per day with severe symptoms; risk for toxic megacolon and bowel perforation
Question 6: Crohn's disease
Answer: deep, transmural inflammation of any part of GI tract; fistulas/strictures common, "cobblestone"
appearance
Question 7: How is IBD diagnosed?
Answer: colonoscopy with biopsy; also look at inflammatory markers, stool tests, CT, MRI
Question 8: IBD lifestyle modifications
Answer: smaller/more frequent meals, low fat/dairy diet, hydrate, avoid lactose/sorbitol
Question 9: Should pts with IBD take a multivitamin?
Answer: yes - B12, folate, vitamin D, Ca, iron, zinc deficiencies common
Question 10: nicotine and IBD
Answer: worsens CD; protective effect in UC
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, Question 11: UC induction of remission options
Answer: 5-ASA, anti-TNF, Stelara, Xeljanz, Entyvio, cyclosporine
Question 12: maintenance of mild UC
Answer: mesalamine
Question 13: maintenance of moderate-severe UC
Answer: Humira, Remicade, Simponi, Stelara, AZA, 6-MP, cyclosporine
Question 14: treatment of refractory UC
Answer: Entyvio, Xeljanz
Question 15: CD induction of remission options
Answer: steroids (+ AZA, 6-MP, MTX); anti-TNF (+ AZA, 6-MP); Stelara
Question 16: mild CD maintenance
Answer: PO budesonide d3mo, then AZA, 6-MP, or MTX
Question 17: moderate-severe CD maintenance
Answer: Humira, Remicade, Cimzia, AZA, 6-MP, MTX, Stelara
Question 18: refractory CD treatment
Answer: Entyvio, Tysabri
Question 19: budesonide DDI
Answer: major 3A4 substrate; separate from antacids (2h)
Question 20: aminosalicylate MOA in UC
Answer: topical anti-inflammatory effect
Question 21: aminosalicylates
Answer: mesalamine, sulfasalazine, balsalazide
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Answers (Grade A+)
Question 1: symptoms of IBD
Answer: bloody diarrhea, rectal urgency, tenesmus, abdominal pain, fatigue
Question 2: tenesmus
Answer: The feeling that you need to pass stools, even though your bowels are already empty
Question 3: What are common triggers of IBD flares?
Answer: infection, NSAIDs, certain foods
Question 4: ulcerative colitis
Answer: confined to rectum and colon, superficial ulcerations; distal disease in descending colon and
rectum only
Question 5: fulminant UC
Answer: >10 bloody stools per day with severe symptoms; risk for toxic megacolon and bowel perforation
Question 6: Crohn's disease
Answer: deep, transmural inflammation of any part of GI tract; fistulas/strictures common, "cobblestone"
appearance
Question 7: How is IBD diagnosed?
Answer: colonoscopy with biopsy; also look at inflammatory markers, stool tests, CT, MRI
Question 8: IBD lifestyle modifications
Answer: smaller/more frequent meals, low fat/dairy diet, hydrate, avoid lactose/sorbitol
Question 9: Should pts with IBD take a multivitamin?
Answer: yes - B12, folate, vitamin D, Ca, iron, zinc deficiencies common
Question 10: nicotine and IBD
Answer: worsens CD; protective effect in UC
Page 1
, Question 11: UC induction of remission options
Answer: 5-ASA, anti-TNF, Stelara, Xeljanz, Entyvio, cyclosporine
Question 12: maintenance of mild UC
Answer: mesalamine
Question 13: maintenance of moderate-severe UC
Answer: Humira, Remicade, Simponi, Stelara, AZA, 6-MP, cyclosporine
Question 14: treatment of refractory UC
Answer: Entyvio, Xeljanz
Question 15: CD induction of remission options
Answer: steroids (+ AZA, 6-MP, MTX); anti-TNF (+ AZA, 6-MP); Stelara
Question 16: mild CD maintenance
Answer: PO budesonide d3mo, then AZA, 6-MP, or MTX
Question 17: moderate-severe CD maintenance
Answer: Humira, Remicade, Cimzia, AZA, 6-MP, MTX, Stelara
Question 18: refractory CD treatment
Answer: Entyvio, Tysabri
Question 19: budesonide DDI
Answer: major 3A4 substrate; separate from antacids (2h)
Question 20: aminosalicylate MOA in UC
Answer: topical anti-inflammatory effect
Question 21: aminosalicylates
Answer: mesalamine, sulfasalazine, balsalazide
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