NAPLEX Gout Questions with Correct Answers (Grade A+)
Question 1: gout
Answer: buildup of uric acid crystals in joints
Question 2: uric acid
Answer: end product of purine metabolism; excreted renally and through GI tract
Question 3: asymptomatic hyperuricemia
Answer: do not need to treat, monitor for gout sx
Question 4: Where does gout usually occur?
Answer: metatarsophalangeal joint
Question 5: How is gout diagnosed?
Answer: increased UA level, synovial fluid analysis, x-ray/MRI/CT to confirm
Question 6: What are risk factors for gout?
Answer: male, obese, excess alcohol intake (beer), HTN, CKD
Question 7: What drugs increase risk for gout?
Answer: aspirin, tacrolimus, cyclosporine, diuretics, niacin, pyrazinamide, chemo/TLS, pancreatic enzymes
Question 8: What foods should be avoided in pts with gout?
Answer: organ meats, high fructose corn syrup, alcohol
Question 9: How is an acute gout attack treated?
Answer: colchicine, steroids, NSAIDs
Question 10: How can gout be prevented?
Answer: allopurinol, febuxostat, probenecid, lesinurad, pegloticase
Question 11: colchicine drug interactions
Answer: avoid strong 3A4 and p-gp inhibitors
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, Question 12: When is gout ppx indicated?
Answer: repeat attacks, joint damage, tophi
Question 13: tophi
Answer: small, whitish nodules of uric acid
Question 14: What is the goal uric acid in gout prevention?
Answer: <6
Question 15: allopurinol, febuxostat MOA
Answer: Xanthine oxidase inhibitors, prevent the formation of uric acid
Question 16: probenecid, lesinurad MOA
Answer: uricosuric agent - inhibits reabsorption of UA in the proximal tubule
Question 17: pegloticase MOA
Answer: recombinant uricase enzyme, inactivates UA to allantoin
Question 18: What is used for severe, refractory gout?
Answer: pegloticase
Question 19: What other drugs should be avoided with allopurinol or febuxostat?
Answer: mercaptopurine, azathioprine
Question 20: What drugs should be avoided with probenecid?
Answer: aspirin, methotrexate, penicillins, cephalosporins, carbapenems - inhibits clearance
Question 21: tumor lysis syndrome
Answer: rapid release of purines into the blood that are converted to UA causing hyperuricemia and
electrolyte abnormalities
Question 22: How is TLS treated?
Answer: rasburicase
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Question 1: gout
Answer: buildup of uric acid crystals in joints
Question 2: uric acid
Answer: end product of purine metabolism; excreted renally and through GI tract
Question 3: asymptomatic hyperuricemia
Answer: do not need to treat, monitor for gout sx
Question 4: Where does gout usually occur?
Answer: metatarsophalangeal joint
Question 5: How is gout diagnosed?
Answer: increased UA level, synovial fluid analysis, x-ray/MRI/CT to confirm
Question 6: What are risk factors for gout?
Answer: male, obese, excess alcohol intake (beer), HTN, CKD
Question 7: What drugs increase risk for gout?
Answer: aspirin, tacrolimus, cyclosporine, diuretics, niacin, pyrazinamide, chemo/TLS, pancreatic enzymes
Question 8: What foods should be avoided in pts with gout?
Answer: organ meats, high fructose corn syrup, alcohol
Question 9: How is an acute gout attack treated?
Answer: colchicine, steroids, NSAIDs
Question 10: How can gout be prevented?
Answer: allopurinol, febuxostat, probenecid, lesinurad, pegloticase
Question 11: colchicine drug interactions
Answer: avoid strong 3A4 and p-gp inhibitors
Page 1
, Question 12: When is gout ppx indicated?
Answer: repeat attacks, joint damage, tophi
Question 13: tophi
Answer: small, whitish nodules of uric acid
Question 14: What is the goal uric acid in gout prevention?
Answer: <6
Question 15: allopurinol, febuxostat MOA
Answer: Xanthine oxidase inhibitors, prevent the formation of uric acid
Question 16: probenecid, lesinurad MOA
Answer: uricosuric agent - inhibits reabsorption of UA in the proximal tubule
Question 17: pegloticase MOA
Answer: recombinant uricase enzyme, inactivates UA to allantoin
Question 18: What is used for severe, refractory gout?
Answer: pegloticase
Question 19: What other drugs should be avoided with allopurinol or febuxostat?
Answer: mercaptopurine, azathioprine
Question 20: What drugs should be avoided with probenecid?
Answer: aspirin, methotrexate, penicillins, cephalosporins, carbapenems - inhibits clearance
Question 21: tumor lysis syndrome
Answer: rapid release of purines into the blood that are converted to UA causing hyperuricemia and
electrolyte abnormalities
Question 22: How is TLS treated?
Answer: rasburicase
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