NAPLEX Hepatitis and Liver Disease Questions with Correct
Answers (Grade A+)
Question 1: What are the most common causes of hepatitis?
Answer: viral, alcohol, drugs, autoimmune
Question 2: What viruses cause hepatitis?
Answer: hep A, B, C, D, E; herpes, CMV, EBV, adenovirus
Question 3: hepatitis A virus
Answer: acute, self-limiting infection; fecal-oral transmission
Question 4: How is hepatitis A treated?
Answer: supportive care
Question 5: hepatitis B virus
Answer: acute or chronic infection, blood/body fluid transmission
Question 6: How is hepatitis B treated?
Answer: peg-interferon, tenofovir, entecavir
Question 7: hepatitis C virus
Answer: acute or chronic infection, blood/body fluid transmission
Question 8: How is hepatitis C treated?
Answer: direct acting antivirals with or without ribavirin
Question 9: Who should be screened for hepatitis?
Answer: everyone over 18 at least once - HBV/HCV; with each pregnancy
Question 10: What are the factors that go into selecting a hepatitis C drug regimen?
Answer: genotype, cirrhosis, previous treatment
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, Question 11: What are the NS3/4A protease inhibitors?
Answer: glecaprevir, grazoprevir, viloxaprevir
Question 12: What are the NS5A replication complex inhibitors?
Answer: elbasvir, ledipasvir, pibrentasvir, velpatasvir
Question 13: What is the NS5B protease inhibitor?
Answer: sofosbuvir
Question 14: What are the 2 regimens preferred for HCV in treatment naive patients who do not have
cirrhosis?
Answer: Mavyret (glecaprevir/pibrentasvir) or Epclusa (sofosbuvir/velpatasvir)
Question 15: All HCV antivirals have a risk for -
Answer: reactivation of HBV; hypoglycemia when used with insulin
Question 16: Which HCV antiviral is contraindicated with amiodarone?
Answer: any containing sofosbuvir - severe bradycardia
Question 17: What should be monitored with HCV antivirals?
Answer: LFTs, HCV-RNA
Question 18: Mavyret
Answer: glecaprevir/pibrentasvir
Question 19: glecaprevir/pibrentasvir
Answer: Mavyret
Question 20: What are the contraindications for Mavyret?
Answer: moderate-severe hepatic impairment, history of hepatic decompensation, use with strong 3A4
inducers, ethinyl estradiol, simvastatin, lovastatin, efavirenz, HIV protease inhibitors, cyclosporine
>100mg/day
Question 21: Which HCV antivirals are contraindicated with strong 3A4 inducers?
Answer: all
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Answers (Grade A+)
Question 1: What are the most common causes of hepatitis?
Answer: viral, alcohol, drugs, autoimmune
Question 2: What viruses cause hepatitis?
Answer: hep A, B, C, D, E; herpes, CMV, EBV, adenovirus
Question 3: hepatitis A virus
Answer: acute, self-limiting infection; fecal-oral transmission
Question 4: How is hepatitis A treated?
Answer: supportive care
Question 5: hepatitis B virus
Answer: acute or chronic infection, blood/body fluid transmission
Question 6: How is hepatitis B treated?
Answer: peg-interferon, tenofovir, entecavir
Question 7: hepatitis C virus
Answer: acute or chronic infection, blood/body fluid transmission
Question 8: How is hepatitis C treated?
Answer: direct acting antivirals with or without ribavirin
Question 9: Who should be screened for hepatitis?
Answer: everyone over 18 at least once - HBV/HCV; with each pregnancy
Question 10: What are the factors that go into selecting a hepatitis C drug regimen?
Answer: genotype, cirrhosis, previous treatment
Page 1
, Question 11: What are the NS3/4A protease inhibitors?
Answer: glecaprevir, grazoprevir, viloxaprevir
Question 12: What are the NS5A replication complex inhibitors?
Answer: elbasvir, ledipasvir, pibrentasvir, velpatasvir
Question 13: What is the NS5B protease inhibitor?
Answer: sofosbuvir
Question 14: What are the 2 regimens preferred for HCV in treatment naive patients who do not have
cirrhosis?
Answer: Mavyret (glecaprevir/pibrentasvir) or Epclusa (sofosbuvir/velpatasvir)
Question 15: All HCV antivirals have a risk for -
Answer: reactivation of HBV; hypoglycemia when used with insulin
Question 16: Which HCV antiviral is contraindicated with amiodarone?
Answer: any containing sofosbuvir - severe bradycardia
Question 17: What should be monitored with HCV antivirals?
Answer: LFTs, HCV-RNA
Question 18: Mavyret
Answer: glecaprevir/pibrentasvir
Question 19: glecaprevir/pibrentasvir
Answer: Mavyret
Question 20: What are the contraindications for Mavyret?
Answer: moderate-severe hepatic impairment, history of hepatic decompensation, use with strong 3A4
inducers, ethinyl estradiol, simvastatin, lovastatin, efavirenz, HIV protease inhibitors, cyclosporine
>100mg/day
Question 21: Which HCV antivirals are contraindicated with strong 3A4 inducers?
Answer: all
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