PAT 201 - TEST 1: all drugs Questions with
Verified Correct Answers
whats a agonist drug?
mimics or enhances action of a receptor
response can be greater than endogenous substances
what is a partial agonist drug?
display both agonistic and antagonistic effects, produces weaker responses than endogenous
substances
what is a drug antagonist?
prevents action by competing with endogenous substance or a drug agonist at a receptor site
morphine is an opioid ________ and naloxone is an opioid __________
morphine = opioid agonist
naloxone = opioid antagonist
what 2 receptors do opioids usually bind to?
mu and kappa
what do mu receptors usually cause?
analgesia (strong pain relief)
respiratory depression (serious)
decreased GI motility
sedation
physical depedence (euphoria)
,what do kappa receptors usually cause?
analgesia (less than mu)
decreased GI motility
sedation
less respiratory depression than mu
can cause dysphoria (unpleasent mood)
a med that binds to both kappa and mu receptors would be a?
pure opioid agonist
a med that binds to ONLY mu or kappa receptors would be a?
mixed opioid agonist
a med that binds to blocks both kappa and mu receptors would be a?
pure opioid antagonist
what are the indications of use for morphine?
serious/severe acute and chronic pain, MI pain, cancer pain, relief of shortness of breath
what is the mechanism of action for morphine?
binds to mu and kappa receptors, mimics endogenous opioids like endorphins and
enkephalins
what are the adverse effects for morphine?
orthostatic hypotension (becuz of peripheral vasodilation)
overdose: respiratory depression, cardiac arrest
dysphoria, dizziness, hallucinations
, what should a nursing implications for morphine?
vital signs, respiratory, CNS, pain
alcohol use -> can increase resp depression, hypotension, overdose
tell the patient they might feel drowsiness, nausea, constipation
report difficulty breathing, dizziness, confusion, severe constipation, unrelieved pain
what is the indication of use for naloxone?
acute opioid intoxication, opioid overdose: based off resp depression
for post operative opiod depression (excessive sedation or slow breathing)
and opioid pruritis (itching)
what is the mechanism of action for naloxone?
compete with mu and kappa opioid receptors
block opioids from binding which results in reversal of opioids
desired effect of naloxone?
partial or complete reversal of resp depresion caused by opioids
improved lvl of consciousness
restoration of adequate breathing
Verified Correct Answers
whats a agonist drug?
mimics or enhances action of a receptor
response can be greater than endogenous substances
what is a partial agonist drug?
display both agonistic and antagonistic effects, produces weaker responses than endogenous
substances
what is a drug antagonist?
prevents action by competing with endogenous substance or a drug agonist at a receptor site
morphine is an opioid ________ and naloxone is an opioid __________
morphine = opioid agonist
naloxone = opioid antagonist
what 2 receptors do opioids usually bind to?
mu and kappa
what do mu receptors usually cause?
analgesia (strong pain relief)
respiratory depression (serious)
decreased GI motility
sedation
physical depedence (euphoria)
,what do kappa receptors usually cause?
analgesia (less than mu)
decreased GI motility
sedation
less respiratory depression than mu
can cause dysphoria (unpleasent mood)
a med that binds to both kappa and mu receptors would be a?
pure opioid agonist
a med that binds to ONLY mu or kappa receptors would be a?
mixed opioid agonist
a med that binds to blocks both kappa and mu receptors would be a?
pure opioid antagonist
what are the indications of use for morphine?
serious/severe acute and chronic pain, MI pain, cancer pain, relief of shortness of breath
what is the mechanism of action for morphine?
binds to mu and kappa receptors, mimics endogenous opioids like endorphins and
enkephalins
what are the adverse effects for morphine?
orthostatic hypotension (becuz of peripheral vasodilation)
overdose: respiratory depression, cardiac arrest
dysphoria, dizziness, hallucinations
, what should a nursing implications for morphine?
vital signs, respiratory, CNS, pain
alcohol use -> can increase resp depression, hypotension, overdose
tell the patient they might feel drowsiness, nausea, constipation
report difficulty breathing, dizziness, confusion, severe constipation, unrelieved pain
what is the indication of use for naloxone?
acute opioid intoxication, opioid overdose: based off resp depression
for post operative opiod depression (excessive sedation or slow breathing)
and opioid pruritis (itching)
what is the mechanism of action for naloxone?
compete with mu and kappa opioid receptors
block opioids from binding which results in reversal of opioids
desired effect of naloxone?
partial or complete reversal of resp depresion caused by opioids
improved lvl of consciousness
restoration of adequate breathing
