NURS 660 Psychopharmacology Exam 2 | NEWEST UPDATED
ACTUAL | VERIFIED ANSWERS AND COMPLETE EXAM PREP
• What is an ADR of Clomipramine (Anafranil)? -✓✓ANSWER: QTc
prolongation
• Amitriptyline (Elavil) MOA? -✓✓ANSWER: TCA- Boosts serotonin and
norepinephrine/noradrenaline
• Amitriptyline (Elavil) ADR? -✓✓ANSWER: TCA toxicity (*WIDENED QRS*)
• _____ is the only TCA with an established therapeutic window (concentrations
<50 or >150 are less likely to work) -✓✓ANSWER: Nortriptyline (Pamelor)
• Nortriptyline (Pamelor) MOA? -✓✓ANSWER: TCA- Serotonin, norepinephrine
reuptake inhibitor (Predominantly a NE/noradrenaline reuptake inhibitor (which
increases DA); NET > SERT (At higher doses, may also boost serotonin)
• Imipramine (Tofranil) MOA? -✓✓ANSWER: TCA- Blocks serotonin reuptake
pump, blocks NE reuptake pump (increase DA)
• What drug may be effective in treating enuresis b/c of its anticholinergic
properties? -✓✓ANSWER: Imipramine (Tofranil) (TCA)
• What lab tests are recommended for patients taking TCAs? -✓✓ANSWER:
Baseline EKG (patients >50y/o)
, • Doxepin (Sinequan, Silenor) MOA? -✓✓ANSWER: TCA- Blocks serotonin
reuptake pump, blocks norepinephrine reuptake pump (increases DA)
• Doxepin (Sinequan, Silenor) may be effective in treating what? -✓✓ANSWER:
Skin conditions (d/t strong antihistamine properties) (potent H1 blocker)
• What drug may be effective in treating skin conditions b/c of its strong
antihistamine properties? -✓✓ANSWER: Doxepin (Sinequan, Silenor) (TCA)
• What drug? At hypnotic doses (3-6mg/day), selectively and potently blocks H1
receptors, decreases wakefulness and thus promoting sleep -✓✓ANSWER:
Doxepin (Sinequan, Silenor) (TCA)
• Phenelzine (Nardil), Tranylcypromine (Parnate), Isocarboxazid (Marplan) "Not
Popular Meds" are examples of what drug class? -✓✓ANSWER: MAOIs
(Monoamine Oxidase Inhibitors)
• MAOIs increase all 3 monoamines (_____, _____, & _____) -✓✓ANSWER:
5HT, NE, & DA
• MAOIs increase all 3 monoamines (5HT, NE, & DA) by blocking the enzyme
that breaks them down (_____ & _____) -✓✓ANSWER: MAO-A & MAO-B
• What is the only antidepressant that directly increases neurotransmissions for all
3 monoamine neurotransmitters? -✓✓ANSWER: MAOIs- Phenelzine (Nardil),
Tranylcypromine (Parnate), Isocarboxazid (Marplan)
ACTUAL | VERIFIED ANSWERS AND COMPLETE EXAM PREP
• What is an ADR of Clomipramine (Anafranil)? -✓✓ANSWER: QTc
prolongation
• Amitriptyline (Elavil) MOA? -✓✓ANSWER: TCA- Boosts serotonin and
norepinephrine/noradrenaline
• Amitriptyline (Elavil) ADR? -✓✓ANSWER: TCA toxicity (*WIDENED QRS*)
• _____ is the only TCA with an established therapeutic window (concentrations
<50 or >150 are less likely to work) -✓✓ANSWER: Nortriptyline (Pamelor)
• Nortriptyline (Pamelor) MOA? -✓✓ANSWER: TCA- Serotonin, norepinephrine
reuptake inhibitor (Predominantly a NE/noradrenaline reuptake inhibitor (which
increases DA); NET > SERT (At higher doses, may also boost serotonin)
• Imipramine (Tofranil) MOA? -✓✓ANSWER: TCA- Blocks serotonin reuptake
pump, blocks NE reuptake pump (increase DA)
• What drug may be effective in treating enuresis b/c of its anticholinergic
properties? -✓✓ANSWER: Imipramine (Tofranil) (TCA)
• What lab tests are recommended for patients taking TCAs? -✓✓ANSWER:
Baseline EKG (patients >50y/o)
, • Doxepin (Sinequan, Silenor) MOA? -✓✓ANSWER: TCA- Blocks serotonin
reuptake pump, blocks norepinephrine reuptake pump (increases DA)
• Doxepin (Sinequan, Silenor) may be effective in treating what? -✓✓ANSWER:
Skin conditions (d/t strong antihistamine properties) (potent H1 blocker)
• What drug may be effective in treating skin conditions b/c of its strong
antihistamine properties? -✓✓ANSWER: Doxepin (Sinequan, Silenor) (TCA)
• What drug? At hypnotic doses (3-6mg/day), selectively and potently blocks H1
receptors, decreases wakefulness and thus promoting sleep -✓✓ANSWER:
Doxepin (Sinequan, Silenor) (TCA)
• Phenelzine (Nardil), Tranylcypromine (Parnate), Isocarboxazid (Marplan) "Not
Popular Meds" are examples of what drug class? -✓✓ANSWER: MAOIs
(Monoamine Oxidase Inhibitors)
• MAOIs increase all 3 monoamines (_____, _____, & _____) -✓✓ANSWER:
5HT, NE, & DA
• MAOIs increase all 3 monoamines (5HT, NE, & DA) by blocking the enzyme
that breaks them down (_____ & _____) -✓✓ANSWER: MAO-A & MAO-B
• What is the only antidepressant that directly increases neurotransmissions for all
3 monoamine neurotransmitters? -✓✓ANSWER: MAOIs- Phenelzine (Nardil),
Tranylcypromine (Parnate), Isocarboxazid (Marplan)
