Robbins Pathology review: Ch 1-4 Comprehensive
Test Bank Exam (10th Ed.) — Chapter wise MCQs with
Verified Explanations || Latest Update 2026
ANSWERS: Collagen
A 54-year-old man undergoes laparoscopic hernia repair. In spite of the
small size of the incisions, he has poor wound healing. Further history
reveals that his usual diet has poor nutritional value and is deficient in
vitamin C. Synthesis of which of the following extracellular matrix
components is most affected by this deficiency?
A Collagen
B Elastin
C Fibronectin
D Integrin
E Laminin
,ANSWERS:
following mediators is most likely being expressed to produce this
appearance?
,ANSWERS: Increased hemoglobin A1c
A 48-year-old man has ill-fitting shoes and develops a local injury to the
sole of his foot that fails to heal after 3 months. On examination there is
loss of the overlying epithelium in a 2-cm area on the ball of his left foot,
with excavation 0.5 cm below the surface, filled with dark, soft material
mixed with yellow exudate. His past history is significant for worsening
renal function and for a myocardial infarction. Which of the following
laboratory test findings is most likely indicative of the underlying disease
that is responsible for the delayed healing?
A Decreased cortisol
B Decreased lactic acid
C Decreased vitamin D
D Increased albumin
E Increased C-reactive protein
F Increased hemoglobin A1c
ANSWERS: 1 month
A 24-year-old man has marked abdominal pain for 6 hours. He is
diagnosed with acute abdomen and undergoes surgical removal of an
inflamed appendix. The incision site is sutured. A trichrome-stained
section representative of the site with blue appearing collagen is shown
in the figure. How long after the surgery would this appearance most
likely be seen?
A 1 day
B 2 to 3 days
C 4 to 5 days
D 2 weeks
E 1 month
, ANSWERS: Myofibroblast contraction
A 40-year-old man underwent laparotomy for a perforated sigmoid
colon diverticulum. A wound infection complicated the postoperative
course, and surgical wound dehiscence occurred. Primary closure was
no longer possible, and the wound "granulated in." Six weeks later, the
wound is only 10% of its original size. Which of the following processes
best accounts for the observed decrease in wound size over the past 6
weeks?
A Elaboration of adhesive glycoproteins
B Increase in synthesis of collagen
C Inhibition of metalloproteinases
D Myofibroblast contraction
E Resolution of subcutaneous edema
ANSWERS: Integrin
In an experiment involving observations on wound healing, researchers
noted that intracytoplasmic cytoskeletal elements, including actin,
interact with the extracellular matrix to promote cell attachment and
migration in wound healing. Which of the following substances is most
likely responsible for such interaction between the cytoskeleton and the
extracellular matrix?
A Epidermal growth factor
B Fibronectin
C Integrin
D Platelet-derived growth factor
E Type IV collagen
F Vascular endothelial growth factor
Test Bank Exam (10th Ed.) — Chapter wise MCQs with
Verified Explanations || Latest Update 2026
ANSWERS: Collagen
A 54-year-old man undergoes laparoscopic hernia repair. In spite of the
small size of the incisions, he has poor wound healing. Further history
reveals that his usual diet has poor nutritional value and is deficient in
vitamin C. Synthesis of which of the following extracellular matrix
components is most affected by this deficiency?
A Collagen
B Elastin
C Fibronectin
D Integrin
E Laminin
,ANSWERS:
following mediators is most likely being expressed to produce this
appearance?
,ANSWERS: Increased hemoglobin A1c
A 48-year-old man has ill-fitting shoes and develops a local injury to the
sole of his foot that fails to heal after 3 months. On examination there is
loss of the overlying epithelium in a 2-cm area on the ball of his left foot,
with excavation 0.5 cm below the surface, filled with dark, soft material
mixed with yellow exudate. His past history is significant for worsening
renal function and for a myocardial infarction. Which of the following
laboratory test findings is most likely indicative of the underlying disease
that is responsible for the delayed healing?
A Decreased cortisol
B Decreased lactic acid
C Decreased vitamin D
D Increased albumin
E Increased C-reactive protein
F Increased hemoglobin A1c
ANSWERS: 1 month
A 24-year-old man has marked abdominal pain for 6 hours. He is
diagnosed with acute abdomen and undergoes surgical removal of an
inflamed appendix. The incision site is sutured. A trichrome-stained
section representative of the site with blue appearing collagen is shown
in the figure. How long after the surgery would this appearance most
likely be seen?
A 1 day
B 2 to 3 days
C 4 to 5 days
D 2 weeks
E 1 month
, ANSWERS: Myofibroblast contraction
A 40-year-old man underwent laparotomy for a perforated sigmoid
colon diverticulum. A wound infection complicated the postoperative
course, and surgical wound dehiscence occurred. Primary closure was
no longer possible, and the wound "granulated in." Six weeks later, the
wound is only 10% of its original size. Which of the following processes
best accounts for the observed decrease in wound size over the past 6
weeks?
A Elaboration of adhesive glycoproteins
B Increase in synthesis of collagen
C Inhibition of metalloproteinases
D Myofibroblast contraction
E Resolution of subcutaneous edema
ANSWERS: Integrin
In an experiment involving observations on wound healing, researchers
noted that intracytoplasmic cytoskeletal elements, including actin,
interact with the extracellular matrix to promote cell attachment and
migration in wound healing. Which of the following substances is most
likely responsible for such interaction between the cytoskeleton and the
extracellular matrix?
A Epidermal growth factor
B Fibronectin
C Integrin
D Platelet-derived growth factor
E Type IV collagen
F Vascular endothelial growth factor
