FEDERAL MPJE PREP |ACTUAL QUESTIONS AND
VERIFIED ANSWERS|BRAND NEW 2026-2027
UPDATE|GRADED A+
Question 1
What law prohibits the distribution of foods and drugs that are misbranded or
adulterated?
a. Food, Drug, and Cosmetic Act
b. Pure Food and Drug Act
c. Prescription Drug Marketing Act
d. Durham-Humphrey Amendment
e. Kefauver-Harris Amendment
CORRECT ANSWER
B. The Pure Food and Drug Act
Prohibits the distribution of foods and drugs that are contaminated (adulterated) or not
labeled consistently or correctly (misbranded)
Question 2
What is the system that can be used as an electronic substitute for DEA Form 222 when
ordering Schedule II controlled substances?
a. Controlled Online Ordering System
b. Online Opioid Ordering System
c. Controlled Substance Ordering System
d. Federal Controlled Substance Ordering System
1
,e. Scheduled Substance Ordering System
CORRECT ANSWER
C. Controlled Substance Ordering System
CSOS is a secure, electronic program that can be used in place of a DEA Form 222 when
ordering Schedule II controlled substances
Question 3
Which agency is responsible for the federal Controlled Substances Act (CSA)?
a. FBI
b. FDA
c. HHS
d. DEA
e. USP
CORRECT ANSWER
d. DEA
CSA is available online at the DEA's website
Question 4
A pharmacist wants to know if generic Warfarin tablets are bioequivalent to brand name
Coumadin tablets. Where can this information be found?
a. Purple Book
b. Blue Book
2
,c. Green Book
d. Orange Book
e. Red Book
CORRECT ANSWER
d. Orange Book
The primary source for determining therapeutic equivalence of drugs
Question 5
When a pharmacy submits a DEA Form 222 (single sheet) to purchase Schedule II
controlled substances, who keeps the original copy of the DEA Form 222?
a. The pharmacy
b. The supplier
c. The manufacturer
d. The DEA
e. The pharmacist
CORRECT ANSWER
b. The supplier
When purchasing a Schedule II controlled substance, the pharmacy (purchaser) will fill
out a DEA Form 222 and submit it to the supplier. The supplier receives the original form.
The purchaser makes and keeps a copy of the original for their records. This copy can be
retained in paper or electronic form. Importantly, the purchaser does not have the
option of keeping the original form.
Question 6
3
, Which DEA form must be completed and submitted to the DEA upon discovering a theft or
significant loss of controlled substances?
a. DEA Form 106
b. DEA Form 108
c. DEA Form 222
d. DEA Form 224
e. DEA Form 363
CORRECT ANSWER
a. DEA Form 106
Must be filled out and submitted to DEA upon discovery of theft or significant loss of
controlled substances. There is a section that allows the user to list out the controlled
substances and quantities that were stolen or lost. Submission formally documents the
situation and the pharmacy should retain a copy for their records. The DEA must also
immediately be contacted by phone, fax, or brief written message to alert them of the
situation. Local authorities should also be alerted.
Question 7
What is the first application that must be submitted to the FDA before a drug can be
administered to humans in order to start testing?
a. Supplemental New Drug Application (SNDA)
b. Investigational New Drug Application (IND)
c. New Drug Application (NDA)
d. Abbreviated New Drug Application (ANDA)
e. Experimental New Drug Application (ENDA)
CORRECT ANSWER
b. IND
4
VERIFIED ANSWERS|BRAND NEW 2026-2027
UPDATE|GRADED A+
Question 1
What law prohibits the distribution of foods and drugs that are misbranded or
adulterated?
a. Food, Drug, and Cosmetic Act
b. Pure Food and Drug Act
c. Prescription Drug Marketing Act
d. Durham-Humphrey Amendment
e. Kefauver-Harris Amendment
CORRECT ANSWER
B. The Pure Food and Drug Act
Prohibits the distribution of foods and drugs that are contaminated (adulterated) or not
labeled consistently or correctly (misbranded)
Question 2
What is the system that can be used as an electronic substitute for DEA Form 222 when
ordering Schedule II controlled substances?
a. Controlled Online Ordering System
b. Online Opioid Ordering System
c. Controlled Substance Ordering System
d. Federal Controlled Substance Ordering System
1
,e. Scheduled Substance Ordering System
CORRECT ANSWER
C. Controlled Substance Ordering System
CSOS is a secure, electronic program that can be used in place of a DEA Form 222 when
ordering Schedule II controlled substances
Question 3
Which agency is responsible for the federal Controlled Substances Act (CSA)?
a. FBI
b. FDA
c. HHS
d. DEA
e. USP
CORRECT ANSWER
d. DEA
CSA is available online at the DEA's website
Question 4
A pharmacist wants to know if generic Warfarin tablets are bioequivalent to brand name
Coumadin tablets. Where can this information be found?
a. Purple Book
b. Blue Book
2
,c. Green Book
d. Orange Book
e. Red Book
CORRECT ANSWER
d. Orange Book
The primary source for determining therapeutic equivalence of drugs
Question 5
When a pharmacy submits a DEA Form 222 (single sheet) to purchase Schedule II
controlled substances, who keeps the original copy of the DEA Form 222?
a. The pharmacy
b. The supplier
c. The manufacturer
d. The DEA
e. The pharmacist
CORRECT ANSWER
b. The supplier
When purchasing a Schedule II controlled substance, the pharmacy (purchaser) will fill
out a DEA Form 222 and submit it to the supplier. The supplier receives the original form.
The purchaser makes and keeps a copy of the original for their records. This copy can be
retained in paper or electronic form. Importantly, the purchaser does not have the
option of keeping the original form.
Question 6
3
, Which DEA form must be completed and submitted to the DEA upon discovering a theft or
significant loss of controlled substances?
a. DEA Form 106
b. DEA Form 108
c. DEA Form 222
d. DEA Form 224
e. DEA Form 363
CORRECT ANSWER
a. DEA Form 106
Must be filled out and submitted to DEA upon discovery of theft or significant loss of
controlled substances. There is a section that allows the user to list out the controlled
substances and quantities that were stolen or lost. Submission formally documents the
situation and the pharmacy should retain a copy for their records. The DEA must also
immediately be contacted by phone, fax, or brief written message to alert them of the
situation. Local authorities should also be alerted.
Question 7
What is the first application that must be submitted to the FDA before a drug can be
administered to humans in order to start testing?
a. Supplemental New Drug Application (SNDA)
b. Investigational New Drug Application (IND)
c. New Drug Application (NDA)
d. Abbreviated New Drug Application (ANDA)
e. Experimental New Drug Application (ENDA)
CORRECT ANSWER
b. IND
4
