Diagnostic Reasoning: 250-Question
Practice Bank
1. A 68-year-old male with a history of benign prostatic hyperplasia presents
for his annual physical. His provider orders a PSA level. The nurse
understands that an elevated PSA is most specific for which of the following
conditions?
A. Urinary tract infection
B. Prostate cancer
C. Acute kidney injury
D. Bladder obstruction
Answer: B. Prostate cancer
2. A nurse is reviewing the diagnostic workup for a patient suspected of
having rheumatoid arthritis. Which laboratory tests should the nurse
anticipate the provider will order? Select all that apply.
A. Rheumatoid Factor (RF)
B. Anti-CCP antibody
C. C-reactive Protein (CRP)
D. Erythrocyte Sedimentation Rate (ESR)
E. Complete Blood Count (CBC)
,Answer: A, B, C, D, E
3. A patient is scheduled for a bone scan using a radioactive isotope. Which
pre-procedure instruction should the nurse provide?
A. "You will need to fast for 12 hours before the scan."
B. "Remove all metal jewelry and clothing with zippers before the
procedure."
C. "You will be radioactive for several weeks and must avoid contact with
others."
D. "Drink only clear fluids for 48 hours after the injection."
Answer: B. "Remove all metal jewelry and clothing with zippers before the
procedure."
4. A 45-year-old female presents with fatigue, weight gain, constipation, and
bradycardia. Laboratory studies reveal elevated TSH and low T3 and T4
levels. The nurse recognizes these findings are consistent with which
condition?
A. Hyperthyroidism
B. Hypothyroidism
C. Cushing's syndrome
D. Addison's disease
Answer: B. Hypothyroidism
5. A patient with type 1 diabetes presents to the emergency department with
fruity breath, Kussmaul respirations, and altered mental status. Laboratory
,results show high ketones, high anion gap, low potassium, and rising
BUN/creatinine. The nurse recognizes these findings as indicative of:
A. Hyperosmolar hyperglycemic state
B. Diabetic ketoacidosis (DKA)
C. Hypoglycemic shock
D. Acute kidney injury
Answer: B. Diabetic ketoacidosis (DKA)
6. A nurse is caring for a patient who underwent a cystoscopy. Which
statement by the patient indicates a need for further teaching?
A. "I may notice some pink-tinged urine after the procedure."
B. "I should drink plenty of fluids to flush my bladder."
C. "I can resume my normal diet immediately after the procedure."
D. "I should report burning with urination that lasts more than 24 hours."
Answer: C. "I can resume my normal diet immediately after the procedure."
7. A 52-year-old male presents to the emergency department with sudden
onset of severe epigastric pain that radiates to his back. He reports nausea
and vomiting. The pain is steady and worsens when he walks or lies supine.
He admits to drinking approximately 12 beers daily and consumed a large
fatty meal 4 hours prior to symptom onset. His vital signs reveal a
temperature of 101.2°F, heart rate of 112 bpm, and blood pressure of 148/92
mmHg. Laboratory studies show lipase 980 U/L (normal: 10–140), amylase
420 U/L (normal: 30–110), ALT 85 U/L, CRP 18 mg/L, WBC 16,500/µL, and
glucose 198 mg/dL. Which diagnostic imaging study is the first choice to
confirm the diagnosis?
, A. Abdominal ultrasound
B. CT abdomen with contrast
C. MRI abdomen
D. ERCP
Answer: B. CT abdomen with contrast
8. A 45-year-old female presents with RUQ pain, nausea, vomiting, and a low-
grade fever. She reports the pain began approximately 6 hours after eating
fried chicken. On physical examination, the nurse practitioner elicits a
positive Murphy's sign. Her WBC is 14,200/µL. Which of the following
diagnostic tests would be appropriate to order? Select all that apply.
A. RUQ ultrasound
B. HIDA scan
C. CT abdomen
D. ERCP
E. Abdominal x-ray
Answer: A, B
9. A 68-year-old male with a history of alcohol abuse presents with epigastric
pain, nausea, and vomiting. Laboratory studies reveal a lipase of 1,250 U/L
(3× upper limit of normal) and an amylase of 380 U/L. The nurse practitioner
knows that lipase is more sensitive and specific than amylase for
pancreatitis. Which statement about these laboratory findings is most
accurate?