Test Bank for Katzung's
̦̣ Basic & Clinical Pharmacology 16th
Edition by Todd W. Vanderah and Bertram G. Katzung ̦̣
, Page 1 of 822
Basic and Clinical Pharmacology 16th Edition Katzung
̦̣ Trevor Test Bank
Chapter 1. Introduction:
̦̣ The Nature
̦̣ of Drugs
̦̣ & Drug̦̣ Development & Regulation
̦̣
1. A nurse̦̣ working in radiology administers iodine to a patient who is having a
computed̦̣ tomography (CT) scan. The nurse̦̣ working on the oncology unit ̦̣ administers
chemotherapy to patients who have cancer. At the Public̦̣ Health Department, a nurse
̦̣
administers a measles-mumps-ru
̦̣ bella
̦̣ (MMR) vaccine to a 14-month-old child as a
routine
̦̣ immunization.
̦̣ Which branch of
pharmacology best describes the actions of all three nurses?
̦̣
A) Pharmacoeconomics
B) Pharmacotherapeutics
̦̣
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
Feedback:
Pharmacology is the study̦̣ of the biologic effects of chemicals. Nurses ̦̣ are
involved with clinical pharmacology or pharmacotherapeutics, ̦̣ which is a
branch of pharmacology that deals with the uses ̦̣ of drugs
̦̣ to treat, prevent,
and diagnose disease. The radiology nurse ̦̣ is administering a drug̦̣ to help
diagnose a disease. The oncology nurse ̦̣ is administering a drug̦̣ to help treat a
disease. Pharmacoeconomics includes ̦̣ any costs involved in drug̦̣ therapy.
Pharmacodynamics involves how a drug̦̣ affects the body and
pharmacokinetics is how the body acts on the body.
2. A physician has ordered intramuscu
̦̣ lar
̦̣ (IM) injections of morphine, a
narcotic, every 4 hours
̦̣ as needed for pain in a motor vehicle accident victim.
The nurse
̦̣ is aware this drug̦̣ has a high abuse
̦̣ potential. Under what category
would̦̣ morphine be classified?
A) Schedule
̦̣ I
B) Schedule
̦̣ II
WWW.NURSYLAB.COM
, Page 2 of 822
C) Schedule
̦̣ III
D) Schedule
̦̣ IV
Ans: B
Feedback:
Narcotics with a high abuse̦̣ potential are classified as Schedule ̦̣ II drugs ̦̣
because̦̣ of severe dependence liability. Schedu le
̦̣ I dru gs
̦̣ have high abu se
̦̣
potential and no accepted medical use. ̦̣ Schedule
̦̣ III dru gs
̦̣ have a lesser abuse
̦̣
potential than II and an accepted medical use.̦̣ Schedule ̦̣ IV drugs ̦̣ have low
abuse
̦̣ potential and limited dependence liability.
3. When involved in phase III drug̦̣ evaluation
̦̣ studies,
̦̣ what responsibilities
would̦̣ the nurse
̦̣ have?
A) Working with animals who are given experimental drugs
̦̣
B) Choosing appropriate patients to be involved in the drug̦̣ study
̦̣
C) Monitoring and observing patients closely for adverse effects
D) Conducting
̦̣ research to determine effectiveness of the drug̦̣
Ans: C
Feedback:
Phase III studies ̦̣ involve use ̦̣ of a drug̦̣ in a vast clinical population̦̣ in which
patients are asked to record any symptoms they experience while taking the
drugs.̦̣ Nurseș̣ may be responsible for helping collect and analyze the
information to be shared with the Food and Drug̦̣ Administration (FDA) buț̣
would ̦̣ not conduct ̦̣ research independently because ̦̣ nurses
̦̣ do not prescribe
medications. Use of animals in drug̦̣ testing is done in the preclinical trials.
Select patients who are involved in phase II studies ̦̣ to participate in studieș̣
where the participants have the disease the drug̦̣ is intended to treat. These
patients are monitored closely for drug̦̣ action and adverse effects. Phase I
studies
̦̣ involve healthy human̦̣ volunteers
̦̣ who are usu ̦̣ ally
̦̣ paid for their
participation. Nurses ̦̣ may observe for adverse effects and toxicity.
4. What concept is considered when generic drugs
̦̣ are substitu
̦̣ ted
̦̣ for brand
name drugs?
̦̣
A) Bioavailability
WWW.THENURSINGMASTERY.COM
WWW.NURSYLAB.COM
, Page 3 of 822
B) Critical concentration
C) Distribution
̦̣
D) Half-life
Ans: A
Feedback:
Bioavailability is the portion of a dose of a drug̦̣ that reaches the systemic
circulation
̦̣ and is available to act on body cells. Binders used ̦̣ in a generic
drug̦̣ may not be the same as those used ̦̣ in the brand name drug. ̦̣ Therefore,
the way the body breaks down and uses ̦̣ the drug̦̣ may differ, which may
eliminate a generic drug̦̣ substitu
̦̣ tion.
̦̣ Critical concentration is the amount ̦̣ of
a drug̦̣ that is needed to cause ̦̣ a therapeutic ̦̣ effect and should ̦̣ not differ
between generic and brand name medications. Distribution ̦̣ is the phase of
pharmacokinetics, which involves the movement of a drug̦̣ to the bodys
tissueș̣ and is the same in generic and brand name drugs. ̦̣ A drugs ̦̣ half-life is
the time it takes for the amount ̦̣ of dru g
̦̣ to decrease to half the peak level,
which should ̦̣ not change when substitu ̦̣ ting
̦̣ a generic medication.
5. A nurse
̦̣ is assessing the patients home medication use. ̦̣ After listening to the
patient list current
̦̣ medications, the nurse
̦̣ asks what priority question?
̦̣
A) Do you ̦̣ take any generic medications?
B) Are any of these medications orphan drugs?
̦̣
C) Are these medications safe to take during
̦̣ pregnancy?
D) Do you ̦̣ take any over-the-counter
̦̣ medications?
Ans: D
Feedback:
It is important for the nurse̦̣ to specifically question
̦̣ use
̦̣ of over-the-counter̦̣
medications because ̦̣ patients may not consider them important. The patient
is unlikely
̦̣ to know the meaning of orphan drugs ̦̣ unless
̦̣ they too are health
care providers. Safety during ̦̣ pregnancy, use̦̣ of a generic medication, or
classification of orphan drugs ̦̣ are things the patient would ̦̣ be unable
̦̣ to
answer buț̣ could
̦̣ be found
̦̣ in reference books if the nurse ̦̣ wishes to research
them.
WWW.THENURSINGMASTERY.COM
WWW.NURSYLAB.COM
̦̣ Basic & Clinical Pharmacology 16th
Edition by Todd W. Vanderah and Bertram G. Katzung ̦̣
, Page 1 of 822
Basic and Clinical Pharmacology 16th Edition Katzung
̦̣ Trevor Test Bank
Chapter 1. Introduction:
̦̣ The Nature
̦̣ of Drugs
̦̣ & Drug̦̣ Development & Regulation
̦̣
1. A nurse̦̣ working in radiology administers iodine to a patient who is having a
computed̦̣ tomography (CT) scan. The nurse̦̣ working on the oncology unit ̦̣ administers
chemotherapy to patients who have cancer. At the Public̦̣ Health Department, a nurse
̦̣
administers a measles-mumps-ru
̦̣ bella
̦̣ (MMR) vaccine to a 14-month-old child as a
routine
̦̣ immunization.
̦̣ Which branch of
pharmacology best describes the actions of all three nurses?
̦̣
A) Pharmacoeconomics
B) Pharmacotherapeutics
̦̣
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
Feedback:
Pharmacology is the study̦̣ of the biologic effects of chemicals. Nurses ̦̣ are
involved with clinical pharmacology or pharmacotherapeutics, ̦̣ which is a
branch of pharmacology that deals with the uses ̦̣ of drugs
̦̣ to treat, prevent,
and diagnose disease. The radiology nurse ̦̣ is administering a drug̦̣ to help
diagnose a disease. The oncology nurse ̦̣ is administering a drug̦̣ to help treat a
disease. Pharmacoeconomics includes ̦̣ any costs involved in drug̦̣ therapy.
Pharmacodynamics involves how a drug̦̣ affects the body and
pharmacokinetics is how the body acts on the body.
2. A physician has ordered intramuscu
̦̣ lar
̦̣ (IM) injections of morphine, a
narcotic, every 4 hours
̦̣ as needed for pain in a motor vehicle accident victim.
The nurse
̦̣ is aware this drug̦̣ has a high abuse
̦̣ potential. Under what category
would̦̣ morphine be classified?
A) Schedule
̦̣ I
B) Schedule
̦̣ II
WWW.NURSYLAB.COM
, Page 2 of 822
C) Schedule
̦̣ III
D) Schedule
̦̣ IV
Ans: B
Feedback:
Narcotics with a high abuse̦̣ potential are classified as Schedule ̦̣ II drugs ̦̣
because̦̣ of severe dependence liability. Schedu le
̦̣ I dru gs
̦̣ have high abu se
̦̣
potential and no accepted medical use. ̦̣ Schedule
̦̣ III dru gs
̦̣ have a lesser abuse
̦̣
potential than II and an accepted medical use.̦̣ Schedule ̦̣ IV drugs ̦̣ have low
abuse
̦̣ potential and limited dependence liability.
3. When involved in phase III drug̦̣ evaluation
̦̣ studies,
̦̣ what responsibilities
would̦̣ the nurse
̦̣ have?
A) Working with animals who are given experimental drugs
̦̣
B) Choosing appropriate patients to be involved in the drug̦̣ study
̦̣
C) Monitoring and observing patients closely for adverse effects
D) Conducting
̦̣ research to determine effectiveness of the drug̦̣
Ans: C
Feedback:
Phase III studies ̦̣ involve use ̦̣ of a drug̦̣ in a vast clinical population̦̣ in which
patients are asked to record any symptoms they experience while taking the
drugs.̦̣ Nurseș̣ may be responsible for helping collect and analyze the
information to be shared with the Food and Drug̦̣ Administration (FDA) buț̣
would ̦̣ not conduct ̦̣ research independently because ̦̣ nurses
̦̣ do not prescribe
medications. Use of animals in drug̦̣ testing is done in the preclinical trials.
Select patients who are involved in phase II studies ̦̣ to participate in studieș̣
where the participants have the disease the drug̦̣ is intended to treat. These
patients are monitored closely for drug̦̣ action and adverse effects. Phase I
studies
̦̣ involve healthy human̦̣ volunteers
̦̣ who are usu ̦̣ ally
̦̣ paid for their
participation. Nurses ̦̣ may observe for adverse effects and toxicity.
4. What concept is considered when generic drugs
̦̣ are substitu
̦̣ ted
̦̣ for brand
name drugs?
̦̣
A) Bioavailability
WWW.THENURSINGMASTERY.COM
WWW.NURSYLAB.COM
, Page 3 of 822
B) Critical concentration
C) Distribution
̦̣
D) Half-life
Ans: A
Feedback:
Bioavailability is the portion of a dose of a drug̦̣ that reaches the systemic
circulation
̦̣ and is available to act on body cells. Binders used ̦̣ in a generic
drug̦̣ may not be the same as those used ̦̣ in the brand name drug. ̦̣ Therefore,
the way the body breaks down and uses ̦̣ the drug̦̣ may differ, which may
eliminate a generic drug̦̣ substitu
̦̣ tion.
̦̣ Critical concentration is the amount ̦̣ of
a drug̦̣ that is needed to cause ̦̣ a therapeutic ̦̣ effect and should ̦̣ not differ
between generic and brand name medications. Distribution ̦̣ is the phase of
pharmacokinetics, which involves the movement of a drug̦̣ to the bodys
tissueș̣ and is the same in generic and brand name drugs. ̦̣ A drugs ̦̣ half-life is
the time it takes for the amount ̦̣ of dru g
̦̣ to decrease to half the peak level,
which should ̦̣ not change when substitu ̦̣ ting
̦̣ a generic medication.
5. A nurse
̦̣ is assessing the patients home medication use. ̦̣ After listening to the
patient list current
̦̣ medications, the nurse
̦̣ asks what priority question?
̦̣
A) Do you ̦̣ take any generic medications?
B) Are any of these medications orphan drugs?
̦̣
C) Are these medications safe to take during
̦̣ pregnancy?
D) Do you ̦̣ take any over-the-counter
̦̣ medications?
Ans: D
Feedback:
It is important for the nurse̦̣ to specifically question
̦̣ use
̦̣ of over-the-counter̦̣
medications because ̦̣ patients may not consider them important. The patient
is unlikely
̦̣ to know the meaning of orphan drugs ̦̣ unless
̦̣ they too are health
care providers. Safety during ̦̣ pregnancy, use̦̣ of a generic medication, or
classification of orphan drugs ̦̣ are things the patient would ̦̣ be unable
̦̣ to
answer buț̣ could
̦̣ be found
̦̣ in reference books if the nurse ̦̣ wishes to research
them.
WWW.THENURSINGMASTERY.COM
WWW.NURSYLAB.COM
