NSG6005 ADVANCED PHARMACOLOGY
FINAL EXAM SOUTH UNIVERSITY
(CORRECT Q & A) SATISFACTION
GUARANTEED
1. Which cytochrome P450 enzyme is responsible for the metabolism of approximately 50
percent of all clinical drugs?
A. CYP2D6
B. CYP1A2
C. CYP3A4
D. CYP2C9
Answer: C
Conceptual Explanation: CYP3A4 is the most abundant hepatic enzyme and is involved in
the metabolism of roughly half of all medications.
2. A patient with a history of asthma is diagnosed with hypertension. Which antihypertensive
class should be used with extreme caution or avoided?
A. Non-selective Beta-Blockers
B. ACE Inhibitors
C. Calcium Channel Blockers
,D. Thiazide Diuretics
Answer: A
Conceptual Explanation: Non-selective beta-blockers like propranolol block Beta-2
receptors in the lungs, potentially causing bronchoconstriction in asthmatic patients.
3. What is the primary mechanism of action of Angiotensin-Converting Enzyme (ACE)
inhibitors?
A. Directly blocking Angiotensin II receptors
B. Blocking the conversion of Angiotensin I to Angiotensin II
C. Inhibiting the release of Renin
D. Increasing the excretion of potassium in the kidneys
Answer: B
Conceptual Explanation: ACE inhibitors prevent the conversion of Angiotensin I to the
potent vasoconstrictor Angiotensin II, leading to vasodilation.
4. Which adverse effect is a characteristic ‘dry cough’ associated with ACE inhibitor therapy
attributed to?
A. Hypokalemia
B. Decreased levels of Nitric Oxide
C. Direct irritation of the bronchial mucosa
D. Increased levels of Bradykinin
, Answer: D
Conceptual Explanation: ACE is also responsible for the breakdown of bradykinin;
inhibiting ACE leads to bradykinin accumulation in the lungs, causing a cough.
5. When initiating Statin therapy, which lab value must be monitored to assess for potential
muscle injury?
A. Serum Creatinine
B. Creatine Kinase (CK)
C. Alkaline Phosphatase
D. Hemoglobin A1c
Answer: B
Conceptual Explanation: Elevated Creatine Kinase levels can indicate myopathy or
rhabdomyolysis, a rare but serious side effect of statins.
6. Amiodarone carries a ‘black box warning’ primarily due to toxicity in which organ system?
A. Pulmonary system
B. Renal system
C. Gastrointestinal system
D. Hematologic system
Answer: A
FINAL EXAM SOUTH UNIVERSITY
(CORRECT Q & A) SATISFACTION
GUARANTEED
1. Which cytochrome P450 enzyme is responsible for the metabolism of approximately 50
percent of all clinical drugs?
A. CYP2D6
B. CYP1A2
C. CYP3A4
D. CYP2C9
Answer: C
Conceptual Explanation: CYP3A4 is the most abundant hepatic enzyme and is involved in
the metabolism of roughly half of all medications.
2. A patient with a history of asthma is diagnosed with hypertension. Which antihypertensive
class should be used with extreme caution or avoided?
A. Non-selective Beta-Blockers
B. ACE Inhibitors
C. Calcium Channel Blockers
,D. Thiazide Diuretics
Answer: A
Conceptual Explanation: Non-selective beta-blockers like propranolol block Beta-2
receptors in the lungs, potentially causing bronchoconstriction in asthmatic patients.
3. What is the primary mechanism of action of Angiotensin-Converting Enzyme (ACE)
inhibitors?
A. Directly blocking Angiotensin II receptors
B. Blocking the conversion of Angiotensin I to Angiotensin II
C. Inhibiting the release of Renin
D. Increasing the excretion of potassium in the kidneys
Answer: B
Conceptual Explanation: ACE inhibitors prevent the conversion of Angiotensin I to the
potent vasoconstrictor Angiotensin II, leading to vasodilation.
4. Which adverse effect is a characteristic ‘dry cough’ associated with ACE inhibitor therapy
attributed to?
A. Hypokalemia
B. Decreased levels of Nitric Oxide
C. Direct irritation of the bronchial mucosa
D. Increased levels of Bradykinin
, Answer: D
Conceptual Explanation: ACE is also responsible for the breakdown of bradykinin;
inhibiting ACE leads to bradykinin accumulation in the lungs, causing a cough.
5. When initiating Statin therapy, which lab value must be monitored to assess for potential
muscle injury?
A. Serum Creatinine
B. Creatine Kinase (CK)
C. Alkaline Phosphatase
D. Hemoglobin A1c
Answer: B
Conceptual Explanation: Elevated Creatine Kinase levels can indicate myopathy or
rhabdomyolysis, a rare but serious side effect of statins.
6. Amiodarone carries a ‘black box warning’ primarily due to toxicity in which organ system?
A. Pulmonary system
B. Renal system
C. Gastrointestinal system
D. Hematologic system
Answer: A
