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NURS 5315 Hematology 2026/2027: 60 Exam Questions & Answers | Anemia, Hemoglobin, RBCs & Iron Studies

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This NURS 5315 Hematology 2026/2027 study document contains 60 multiple-choice exam and practice questions with answers and explanatory rationales designed to support review of essential hematology concepts. The document begins with the functions and components of blood and progresses through red blood cell physiology, hematopoiesis, erythropoiesis, hemoglobin structure and function, coagulation, platelet disorders, anemia, and hematological disease. The uploaded document does not identify a university or institution, so a university name should not be invented for the listing. NURS 5315 Hematology 2026 A major portion of the material focuses on red blood cell production and oxygen transport, including erythropoietin production by the kidneys, the response to tissue hypoxia, bone marrow hematopoiesis, hemoglobin synthesis, heme, globin chains, fetal hemoglobin (HbF), carboxyhemoglobin, methemoglobin, HbA1c, the Bohr effect, and the oxygen-hemoglobin dissociation curve. These concepts align with established hematology references describing erythropoiesis as a bone-marrow process regulated primarily by renal erythropoietin in response to reduced oxygen delivery. Merck Manuals The question set also provides substantial coverage of anemia classification and laboratory interpretation. Students review MCV, MCHC and RDW; microcytic, normocytic and macrocytic patterns; iron deficiency anemia; anemia of chronic illness; aplastic anemia; hemolytic anemia; vitamin B12 and folate deficiency; and sickle cell disease. Particular attention is given to interpreting serum iron, ferritin, total iron-binding capacity (TIBC), and transferrin saturation. The document teaches the classic iron-deficiency pattern of low serum iron and ferritin with increased TIBC and reduced transferrin saturation, consistent with standard clinical references. NURS 5315 Hematology 2026 Merck Manuals Additional exam topics include CBC interpretation, thrombocytopenia, hemophilia, myeloma, coagulation testing, prothrombin time (PT), iron overload/hemochromatosis, occult gastrointestinal blood loss, fetal and neonatal hematology, and age-related hematological changes. The question-and-rationale format makes the material particularly suitable for active recall, self-testing, exam revision, and identifying areas that need further study. NURS 5315 Hematology 2026 Relevant students: This document is most relevant to students taking NURS 5315 or an equivalent hematology-focused nursing/health-sciences course, particularly nursing students reviewing hematology, pathophysiology, adult health, advanced nursing, or laboratory interpretation. It may also be useful as supplementary question-based review for other health-sciences students studying anemia, blood-cell physiology, hemoglobin, and iron metabolism. Because the document itself does not state the degree program, academic level, or institution, those details should not be represented as confirmed facts. NURS 5315 Hematology 2026 Academic references (APA): Gerber, G. F. (2025). Iron deficiency anemia. Merck Manual Professional Edition. The reference supports the document's coverage of iron deficiency, chronic blood loss, ferritin, serum iron, TIBC, transferrin saturation, RDW, and microcytic/hypochromic anemia. Merck Manuals Faruqi, A., Zubair, M., & Mukkamalla, S. K. R. (2024). Iron-binding capacity. StatPearls Publishing. This reference supports the interpretation of TIBC, transferrin, transferrin saturation, and iron-storage abnormalities. NCBI Gerber, G. F. (2024). Red blood cell production. Merck Manual Professional Edition. This reference supports erythropoietin regulation, renal response to hypoxia, bone-marrow erythropoiesis, and the roles of iron, vitamin B12, folate, and heme in RBC production. Merck Manuals Keywords: NURS 5315 exam questions, hematology exam questions, hematology questions and answers, hematology exam, hematology practice questions, hematology study guide, hematology exam preparation, anemia questions and answers, anemia classification, iron deficiency anemia, anemia of chronic disease, aplastic anemia, hemolytic anemia, sickle cell anemia, vitamin B12 deficiency, folate deficiency, erythropoiesis, hematopoiesis, hemoglobin synthesis, red blood cells, RBC indices, MCV MCHC RDW, iron studies, ferritin, TIBC, transferrin saturation, oxygen hemoglobin dissociation curve, Bohr effect, fetal hemoglobin, HbF, HbA1c, carboxyhemoglobin, methemoglobin, thrombocytopenia, hemophilia, coagulation, complete blood count, CBC interpretation, hematology multiple choice questions, nursing hematology practice questions, hematology exam rationales

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NURS 5315 Hematology
2026/2027 Exam Questions and
Answers | Already Graded A+



Which blood component is primarily responsible for oxygen transport?

A) White blood cells

B) Platelets

C) Red blood cells


D) Plasma - ANSWER ✔✔C) Red blood cells




Rationale: Red blood cells contain hemoglobin, which binds oxygen and

transports it to body tissues.

,What is the main protein in red blood cells that binds oxygen?

A) Albumin

B) Hemoglobin

C) Fibrinogen


D) Myoglobin - ANSWER ✔✔Answer: B) Hemoglobin




Rationale: Hemoglobin is the primary oxygen-carrying protein in red

blood cells, essential for oxygen delivery.

Which of the following white blood cells is involved in the allergic

response?

A) Neutrophils

B) Eosinophils

C) Lymphocytes


D) Monocytes - ANSWER ✔✔Answer: B) Eosinophils




Rationale: Eosinophils play a key role in allergic reactions and parasitic

infections.

What is the most common cause of iron deficiency anemia?

,A) Vitamin B12 deficiency

B) Folate deficiency

C) Acute blood loss


D) Chronic blood loss - ANSWER ✔✔Answer: D) Chronic blood loss




Rationale: Chronic blood loss, often due to gastrointestinal bleeding or

heavy menstruation, depletes iron stores.

In which part of the body is erythropoietin mainly produced?

A) Liver

B) Bone marrow

C) Spleen


D) Kidneys - ANSWER ✔✔Answer: D) Kidneys




Rationale: The kidneys produce erythropoietin in response to low oxygen

levels in the blood, stimulating RBC production.

What type of anemia is caused by a lack of intrinsic factor?

A) Iron deficiency anemia

B) Hemolytic anemia

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, C) Aplastic anemia


D) Pernicious anemia - ANSWER ✔✔Answer: D) Pernicious anemia




Rationale: Pernicious anemia is caused by a lack of intrinsic factor,

which is necessary for vitamin B12 absorption.

Which diagnostic test measures the number and types of cells in the

blood?

A) Bone marrow biopsy

B) Complete blood count (CBC)

C) Blood smear


D) Coagulation test - ANSWER ✔✔Answer: B) Complete blood count

(CBC)




Rationale: CBC provides essential information about red blood cells,

white blood cells, and platelets.

What is the primary site of hematopoiesis in adults?

A) Liver

B) Bone marrow

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