NURS 6521 ADVANCED
PHARMACOLOGY FINAL PREP EXAM
(VERIFIED ANSWERS) QUESTIONS
WITH ANSWERS: WALDEN
UNIVERSITY
1. Which pharmacokinetic phase is primarily bypassed when a medication is administered via
the intravenous (IV) route?
A. Metabolism
B. Absorption
C. Distribution
D. Excretion
Answer: B
Conceptual Explanation: IV administration deposits the drug directly into the systemic
circulation, thereby bypassing the absorption process required for oral, subcutaneous, or
intramuscular routes.
2. A patient is prescribed Lisinopril for hypertension. Which biochemical change is responsible
for the common side effect of a dry, hacking cough?
A. Stimulation of beta-2 receptors
,B. Inhibition of prostaglandin synthesis
C. Increased levels of angiotensin II
D. Accumulation of bradykinin
Answer: D
Conceptual Explanation: ACE inhibitors prevent the breakdown of bradykinin in the
lungs; the resulting accumulation of bradykinin irritates the respiratory tract, causing a dry
cough.
3. When prescribing a non-selective beta-blocker like Propranolol, for which pre-existing
condition is the drug strictly contraindicated?
A. Hypertension
B. Glaucoma
C. Asthma
D. Tachycardia
Answer: C
Conceptual Explanation: Non-selective beta-blockers block both beta-1 and beta-2
receptors. Blocking beta-2 receptors in the lungs can cause bronchoconstriction, which is
dangerous for patients with asthma or COPD.
, 4. A patient on Warfarin therapy presents with an INR of 8.5 and minor mucosal bleeding.
Which agent should be administered to reverse the effects of Warfarin?
A. Protamine sulfate
B. Idarucizumab
C. Vitamin K1 (Phytonadione)
D. Flumazenil
Answer: C
Conceptual Explanation: Vitamin K1 is the specific antagonist for Warfarin. Protamine
sulfate is for Heparin, Idarucizumab is for Dabigatran, and Flumazenil is for
Benzodiazepines.
5. Which electrolyte abnormality increases the risk of Digoxin toxicity in a patient
concurrently taking Furosemide?
A. Hypercalcemia
B. Hyperkalemia
C. Hypokalemia
D. Hyponatremia
Answer: C
Conceptual Explanation: Low serum potassium (hypokalemia) enhances the effects of
Digoxin at the myocardial cell level, significantly increasing the risk of toxicity.
PHARMACOLOGY FINAL PREP EXAM
(VERIFIED ANSWERS) QUESTIONS
WITH ANSWERS: WALDEN
UNIVERSITY
1. Which pharmacokinetic phase is primarily bypassed when a medication is administered via
the intravenous (IV) route?
A. Metabolism
B. Absorption
C. Distribution
D. Excretion
Answer: B
Conceptual Explanation: IV administration deposits the drug directly into the systemic
circulation, thereby bypassing the absorption process required for oral, subcutaneous, or
intramuscular routes.
2. A patient is prescribed Lisinopril for hypertension. Which biochemical change is responsible
for the common side effect of a dry, hacking cough?
A. Stimulation of beta-2 receptors
,B. Inhibition of prostaglandin synthesis
C. Increased levels of angiotensin II
D. Accumulation of bradykinin
Answer: D
Conceptual Explanation: ACE inhibitors prevent the breakdown of bradykinin in the
lungs; the resulting accumulation of bradykinin irritates the respiratory tract, causing a dry
cough.
3. When prescribing a non-selective beta-blocker like Propranolol, for which pre-existing
condition is the drug strictly contraindicated?
A. Hypertension
B. Glaucoma
C. Asthma
D. Tachycardia
Answer: C
Conceptual Explanation: Non-selective beta-blockers block both beta-1 and beta-2
receptors. Blocking beta-2 receptors in the lungs can cause bronchoconstriction, which is
dangerous for patients with asthma or COPD.
, 4. A patient on Warfarin therapy presents with an INR of 8.5 and minor mucosal bleeding.
Which agent should be administered to reverse the effects of Warfarin?
A. Protamine sulfate
B. Idarucizumab
C. Vitamin K1 (Phytonadione)
D. Flumazenil
Answer: C
Conceptual Explanation: Vitamin K1 is the specific antagonist for Warfarin. Protamine
sulfate is for Heparin, Idarucizumab is for Dabigatran, and Flumazenil is for
Benzodiazepines.
5. Which electrolyte abnormality increases the risk of Digoxin toxicity in a patient
concurrently taking Furosemide?
A. Hypercalcemia
B. Hyperkalemia
C. Hypokalemia
D. Hyponatremia
Answer: C
Conceptual Explanation: Low serum potassium (hypokalemia) enhances the effects of
Digoxin at the myocardial cell level, significantly increasing the risk of toxicity.
