Nussbaum: Thompson & Thompson Genetics in Medicine, 7th Edition
Test Bank
Chapter 2: The Human Genome and the Chromosomal Basis of Heredity
MULTIPLE CHOICE
1. How many chromosomes do humans normally have in their somatic cells?
A. 22
B. 23
C. 44
D. 45
E. 46
ANS: E
2. In humans, DNA is associated with several classes of proteins and packaged into complexes
known as:
A. Histones
B. Chromatin
C. Nuclei
D. Genomes
E. Double helices
ANS: B
3. Which of the following represents the pairing of nucleotide bases in DNA?
A. Purines-Purines, Pyrimidines-Pyrimidines
B. Adenine-Cytosine, Guanine-Thymine
C. Adenine-Guanine, Cytosine-Thymine
D. Guanine-Cytosine, Adenine-Thymine
E. Deoxyribose-Ribose
ANS: D
4. Which of the following are composed of repetitive DNA elements?
A. Centromeres
B. Alu elements
C. LINE elements
D. Telomeres
E. All of the above
Copyright © 2007, 2004, 2001, 1991, 1986, 1980, 1973, 1966 by Saunders, an imprint of Elsevier Inc. All rights
reserved.
,ANS: E
5. A human somatic cell spends most of its life in this state:
A. Meiosis
B. Mitosis
C. Interphase
D. Zygote
E. Prophase
ANS: C
6. The arms of a chromosome are designated:
A. 1 and 2
B. Short and long
C. p and q
D. Individually for each chromosome
E. A and B
ANS: C
7. An important and distinct feature of meiosis is:
A. Recombination
B. Chromosome condensation
C. Chromosome congression
D. Spindle formation
ANS: A
8. Mitosis and meiosis result in the following chromosome complements, respectively:
A. n, 2n
B. 2n, n
C. Haploid, diploid
D. 2n, 2n
E. n, n
ANS: B
9. Failure of homologous chromosomes to segregate to opposite poles during meiosis is called:
A. Disjunction
B. Missegregation
C. Nondisjunction
Copyright © 2007, 2004, 2001, 1991, 1986, 1980, 1973, 1966 by Saunders, an imprint of Elsevier Inc. All rights
reserved.
,D. Meiotic failure
E. Nonsegregation
ANS: C
10. In human males, when is meiosis initiated and completed?
A. At birth, at ejaculation
B. At puberty, at ejaculation
C. At birth, at puberty
D. At puberty, it is continuous
E. At birth, it is continuous
ANS: D
11. In human females, when is meiosis initiated and completed?
A. At birth, at ovulation
B. At birth, it is continuous
C. At puberty, at fertilization
D. Prenatally, at ovulation
E. Prenatally, at fertilization
ANS: E
MULTIPLE RESPONSE
1. The extent of the haplotype block surrounding a disease mutation depends on which two of
the following factors?
A. Marker phasing
B. Marker association
C. Recombination frequency in the region
D. Number of generations since the disease mutation arose
E. Marker repulsion
ANS: C, D
Copyright © 2007, 2004, 2001, 1991, 1986, 1980, 1973, 1966 by Saunders, an imprint of Elsevier Inc. All rights
reserved.
, Nussbaum: Thompson & Thompson Genetics in Medicine, 7th Edition
Test Bank
Chapter 3: The Human Genome: Gene Structure and Function
MULTIPLE CHOICE
1. Translation involves which type of RNA?
A. Messenger RNA (mRNA)
B. Ribosomal RNA (rRNA)
C. Transfer RNA (tRNA)
D. All of the above
E. None of the above
ANS: D
2. What is the central dogma of molecular biology?
A. DNA to RNA to protein
B. Transcription to splicing to translation
C. Meiosis, recombination, fertilization
D. Mitosis, cell division, cell death
E. DNA synthesis, homologous pairing, recombination
ANS: A
3. What types of sequences are located in the 5' region of human genes?
A. Exons and introns
B. Start and stop codons
C. Promoters and enhancers
D. Splice signals
E. Polyadenylation sequences
ANS: C
4. Which of the following sequences is located in the 3' region of human genes?
A. Splice signals
B. Promoters
C. Start codons
D. Locus control regions
E. Polyadenylation sequences
ANS: E
Copyright © 2007, 2004, 2001, 1991, 1986, 1980, 1973, 1966 by Saunders, an imprint of Elsevier Inc. All rights
reserved.
Test Bank
Chapter 2: The Human Genome and the Chromosomal Basis of Heredity
MULTIPLE CHOICE
1. How many chromosomes do humans normally have in their somatic cells?
A. 22
B. 23
C. 44
D. 45
E. 46
ANS: E
2. In humans, DNA is associated with several classes of proteins and packaged into complexes
known as:
A. Histones
B. Chromatin
C. Nuclei
D. Genomes
E. Double helices
ANS: B
3. Which of the following represents the pairing of nucleotide bases in DNA?
A. Purines-Purines, Pyrimidines-Pyrimidines
B. Adenine-Cytosine, Guanine-Thymine
C. Adenine-Guanine, Cytosine-Thymine
D. Guanine-Cytosine, Adenine-Thymine
E. Deoxyribose-Ribose
ANS: D
4. Which of the following are composed of repetitive DNA elements?
A. Centromeres
B. Alu elements
C. LINE elements
D. Telomeres
E. All of the above
Copyright © 2007, 2004, 2001, 1991, 1986, 1980, 1973, 1966 by Saunders, an imprint of Elsevier Inc. All rights
reserved.
,ANS: E
5. A human somatic cell spends most of its life in this state:
A. Meiosis
B. Mitosis
C. Interphase
D. Zygote
E. Prophase
ANS: C
6. The arms of a chromosome are designated:
A. 1 and 2
B. Short and long
C. p and q
D. Individually for each chromosome
E. A and B
ANS: C
7. An important and distinct feature of meiosis is:
A. Recombination
B. Chromosome condensation
C. Chromosome congression
D. Spindle formation
ANS: A
8. Mitosis and meiosis result in the following chromosome complements, respectively:
A. n, 2n
B. 2n, n
C. Haploid, diploid
D. 2n, 2n
E. n, n
ANS: B
9. Failure of homologous chromosomes to segregate to opposite poles during meiosis is called:
A. Disjunction
B. Missegregation
C. Nondisjunction
Copyright © 2007, 2004, 2001, 1991, 1986, 1980, 1973, 1966 by Saunders, an imprint of Elsevier Inc. All rights
reserved.
,D. Meiotic failure
E. Nonsegregation
ANS: C
10. In human males, when is meiosis initiated and completed?
A. At birth, at ejaculation
B. At puberty, at ejaculation
C. At birth, at puberty
D. At puberty, it is continuous
E. At birth, it is continuous
ANS: D
11. In human females, when is meiosis initiated and completed?
A. At birth, at ovulation
B. At birth, it is continuous
C. At puberty, at fertilization
D. Prenatally, at ovulation
E. Prenatally, at fertilization
ANS: E
MULTIPLE RESPONSE
1. The extent of the haplotype block surrounding a disease mutation depends on which two of
the following factors?
A. Marker phasing
B. Marker association
C. Recombination frequency in the region
D. Number of generations since the disease mutation arose
E. Marker repulsion
ANS: C, D
Copyright © 2007, 2004, 2001, 1991, 1986, 1980, 1973, 1966 by Saunders, an imprint of Elsevier Inc. All rights
reserved.
, Nussbaum: Thompson & Thompson Genetics in Medicine, 7th Edition
Test Bank
Chapter 3: The Human Genome: Gene Structure and Function
MULTIPLE CHOICE
1. Translation involves which type of RNA?
A. Messenger RNA (mRNA)
B. Ribosomal RNA (rRNA)
C. Transfer RNA (tRNA)
D. All of the above
E. None of the above
ANS: D
2. What is the central dogma of molecular biology?
A. DNA to RNA to protein
B. Transcription to splicing to translation
C. Meiosis, recombination, fertilization
D. Mitosis, cell division, cell death
E. DNA synthesis, homologous pairing, recombination
ANS: A
3. What types of sequences are located in the 5' region of human genes?
A. Exons and introns
B. Start and stop codons
C. Promoters and enhancers
D. Splice signals
E. Polyadenylation sequences
ANS: C
4. Which of the following sequences is located in the 3' region of human genes?
A. Splice signals
B. Promoters
C. Start codons
D. Locus control regions
E. Polyadenylation sequences
ANS: E
Copyright © 2007, 2004, 2001, 1991, 1986, 1980, 1973, 1966 by Saunders, an imprint of Elsevier Inc. All rights
reserved.
