TDM Exam Questions With Correct Detailed Answers

The anti-convulsant used to control tonic-clonic (grand mal) seizures is: - correct answers phenytoin A fetal lung maturity test indicates the fetal lung is mature. The PG result will be: - correct answers positive A cardiac glycoside that is used in the treatment of congenital heart failure and arrhythmias by increasing the force and velocity of myocardial contraction is: - correct answers digoxin Blood specimens for digoxin assays should be obtained between 8 hours or more after drug administration because: - correct answers tissue and serum levels need to reach equilibrium A drug the relaxes the smooth muscles of the bronchial passages is: - correct answers theophylline A carbonate salt used to control manic-depressive disorders is: - correct answers lithium Which of the following factors does NOT affect drug disposition? age disease diet none of the above - correct answers none of the above Bioavailability of a drug refers to the: - correct answers fraction of drug absorbed into systemic circulation Toxic levels of therapeutic drugs are: - correct answers above the therapeutic range Three controls and ten patients were run for cyclosporine. One control and two of the patients had no result on the printout. You should: - correct answers repeat everything Technical problems encountered during the collection of an amniotic fluid specimen caused doubt as to whether the specimen was amniotic in origin. Which one of the following procedures would establish that the fluid is amniotic in origin? - correct answers creatinine measurement Phenytoin is 90% bound in normal patients. The therapeutic range is 10-20 ?g/mL. A uremic patient with a decreased ability to bind drugs to plasma proteins would have a concentration that is: - correct answers toxic When the amount of drug entering the body equals the amount eliminated: - correct answers steady state The main reason for suboptimal drug levels in therapeutic drug monitoring is: - correct answers patient noncompliance with dosage regimen The fluorescence polarization assay for fetal lung maturity measures the ratio of: - correct answers phospholipids to albumin Lithium therapy is widely used in the treatment of: - correct answers manic depression In amniotic fluid, the procedure used to determine fetal lung maturity is: - correct answers lecithin/spingomyelin ratio Phenobarbital is a metabolite of: - correct answers primidone When the clinical response does not agree with total drug concentration, free drug levels may be of clinical use in all of the following cases, EXCEPT: - correct answers Patient noncompliance