NU 641 – Advanced Clinical Pharmacology
Exam 1 Questions and Detailed Solutions
EXAM OVERVIEW
| Component | Details |
||-|
| Course | NU 641 – Advanced Clinical
Pharmacology |
| Institution | Regis College |
| Exam | Exam 1 (Weeks 1–3) |
| Format | Multiple Choice, Application-Based,
Clinical Scenarios |
| Core Domains | Pharmacokinetics,
Pharmacodynamics, Prescribing Principles,
Cardiovascular Pharmacology, Autonomic
Agents |
1
,SECTION 1: PHARMACOKINETICS &
PHARMACODYNAMICS
Absorption, Distribution, Metabolism,
Excretion
QUESTION 1: A 68-year-old patient with
chronic kidney disease is prescribed a
medication with a half-life of 8 hours. The
nurse practitioner knows that in this patient,
the drug's half-life will most likely be:
A) Unchanged due to hepatic metabolism
compensation
B) Shortened because of increased protein
binding
C) Prolonged due to reduced renal clearance
2
,D) Variable based on the time of
administration
ANSWER: C
RATIONALE: In patients with chronic kidney
disease, reduced glomerular filtration rate and
renal clearance prolong drug half-life,
necessitating dose adjustments to prevent
toxicity .
QUESTION 2: A drug that follows first-order
kinetics has a half-life of 4 hours. If the initial
dose is 200 mg, how much drug remains in the
body after 12 hours?
3
, A) 25 mg
B) 50 mg
C) 100 mg
D) 12.5 mg
ANSWER: A
RATIONALE: In first-order kinetics, a
constant fraction of the drug is eliminated per
unit time. After each half-life (4 hours), the
amount remaining is halved. After 12 hours,
three half-lives have elapsed (12 ÷ 4 = 3).
Therefore, the remaining amount is 200 mg ×
(1/2)³ = 200 × 0.125 = 25 mg .
4
Exam 1 Questions and Detailed Solutions
EXAM OVERVIEW
| Component | Details |
||-|
| Course | NU 641 – Advanced Clinical
Pharmacology |
| Institution | Regis College |
| Exam | Exam 1 (Weeks 1–3) |
| Format | Multiple Choice, Application-Based,
Clinical Scenarios |
| Core Domains | Pharmacokinetics,
Pharmacodynamics, Prescribing Principles,
Cardiovascular Pharmacology, Autonomic
Agents |
1
,SECTION 1: PHARMACOKINETICS &
PHARMACODYNAMICS
Absorption, Distribution, Metabolism,
Excretion
QUESTION 1: A 68-year-old patient with
chronic kidney disease is prescribed a
medication with a half-life of 8 hours. The
nurse practitioner knows that in this patient,
the drug's half-life will most likely be:
A) Unchanged due to hepatic metabolism
compensation
B) Shortened because of increased protein
binding
C) Prolonged due to reduced renal clearance
2
,D) Variable based on the time of
administration
ANSWER: C
RATIONALE: In patients with chronic kidney
disease, reduced glomerular filtration rate and
renal clearance prolong drug half-life,
necessitating dose adjustments to prevent
toxicity .
QUESTION 2: A drug that follows first-order
kinetics has a half-life of 4 hours. If the initial
dose is 200 mg, how much drug remains in the
body after 12 hours?
3
, A) 25 mg
B) 50 mg
C) 100 mg
D) 12.5 mg
ANSWER: A
RATIONALE: In first-order kinetics, a
constant fraction of the drug is eliminated per
unit time. After each half-life (4 hours), the
amount remaining is halved. After 12 hours,
three half-lives have elapsed (12 ÷ 4 = 3).
Therefore, the remaining amount is 200 mg ×
(1/2)³ = 200 × 0.125 = 25 mg .
4
