NR565 Midterm Week 4 Newest 2026/2027 Questions
and Correct Detailed Answers Already Graded A+
What areas of healthcare most heavily integrate pharmacogenetics into clinical
practice? - CORRECT ANSWER-Oncology & cystic fibrosis population
Think HER2 with breast cancer and CF have 2 defective CFTR genes
Barrier in understanding racial differences in drug pharmacokinetics with
American Indian or Alaskan Natives? - CORRECT ANSWER-Limited to no
research in racial considerations
Purpose of genetic testing with Tamoxifen? - CORRECT ANSWER-Reduce the
risk of therapeutic failure as variation of CYP2D6 will not allow for activation and
conversion to endoxifen which is necessary for treating estrogen sensitive
cancers.
Liver and Kidney functions labs for monitoring? - CORRECT ANSWER-
Creatinine, BUN, GFR, AST, ALT, Bilirubin
Dose of propranolol in migraine reduction - CORRECT ANSWER-20-80mg 3-4X
daily
increases levels of serotonin, prevents beta receptor vasodilation
allow 4-6 weeks to trial treatment
what makes clopidogrel unique among other P2Y12 inhibitors? - CORRECT
ANSWER-relies on cytochrome P450 enzyme to convert into active metabolite
, (CYP2C19) thus requiring this gene to be present to be an effective drug in clot
formation
Alternatives to clopidogrel - CORRECT ANSWER-Brilinta (ticagrelor) or Effient
(Prasugrel) because they are not dependent on CYP2C19 genotype
Name the 4 medications that REQUIRE pharmacogenetic testing - CORRECT
ANSWER-Cetuximab, trastuzumab, maraviroc, dasatinib
2 medications prescribed together that are highly protein bound, what is clinical
outcome? - CORRECT ANSWER-The two drugs compete for availability of
plasma proteins and one or the other becomes increasingly effective, think extra
medication is floating around as it cannot bind to plasma proteins. Warfarin is
highly protein bound.
First consideration in selecting most appropriate beta blocker? - CORRECT
ANSWER-Cardio selectivity
Pregnancy Categories B vs D with beta blockers - CORRECT ANSWER-Atenolol -
D
betaxolol, acebutolol, metoprolol, nadolol, nebivolol, tiolol, propranolol - C
Where are beta 2 receptors located and what do they do? - CORRECT
ANSWER-smooth muscle of eye, arterioles, venules, bronchioles, liver, pancreas,
GI, GU
Stimulate adneylyl cyclase, increase cAMP, activate cardiac G1
and Correct Detailed Answers Already Graded A+
What areas of healthcare most heavily integrate pharmacogenetics into clinical
practice? - CORRECT ANSWER-Oncology & cystic fibrosis population
Think HER2 with breast cancer and CF have 2 defective CFTR genes
Barrier in understanding racial differences in drug pharmacokinetics with
American Indian or Alaskan Natives? - CORRECT ANSWER-Limited to no
research in racial considerations
Purpose of genetic testing with Tamoxifen? - CORRECT ANSWER-Reduce the
risk of therapeutic failure as variation of CYP2D6 will not allow for activation and
conversion to endoxifen which is necessary for treating estrogen sensitive
cancers.
Liver and Kidney functions labs for monitoring? - CORRECT ANSWER-
Creatinine, BUN, GFR, AST, ALT, Bilirubin
Dose of propranolol in migraine reduction - CORRECT ANSWER-20-80mg 3-4X
daily
increases levels of serotonin, prevents beta receptor vasodilation
allow 4-6 weeks to trial treatment
what makes clopidogrel unique among other P2Y12 inhibitors? - CORRECT
ANSWER-relies on cytochrome P450 enzyme to convert into active metabolite
, (CYP2C19) thus requiring this gene to be present to be an effective drug in clot
formation
Alternatives to clopidogrel - CORRECT ANSWER-Brilinta (ticagrelor) or Effient
(Prasugrel) because they are not dependent on CYP2C19 genotype
Name the 4 medications that REQUIRE pharmacogenetic testing - CORRECT
ANSWER-Cetuximab, trastuzumab, maraviroc, dasatinib
2 medications prescribed together that are highly protein bound, what is clinical
outcome? - CORRECT ANSWER-The two drugs compete for availability of
plasma proteins and one or the other becomes increasingly effective, think extra
medication is floating around as it cannot bind to plasma proteins. Warfarin is
highly protein bound.
First consideration in selecting most appropriate beta blocker? - CORRECT
ANSWER-Cardio selectivity
Pregnancy Categories B vs D with beta blockers - CORRECT ANSWER-Atenolol -
D
betaxolol, acebutolol, metoprolol, nadolol, nebivolol, tiolol, propranolol - C
Where are beta 2 receptors located and what do they do? - CORRECT
ANSWER-smooth muscle of eye, arterioles, venules, bronchioles, liver, pancreas,
GI, GU
Stimulate adneylyl cyclase, increase cAMP, activate cardiac G1
