PMHNP Pharmacology Questions and Answers PMHNP Pharmacology Study Guide PMHNP Pharmacology Exam Review PMHNP Practice Questions 2026/2027

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PMHNP: Pharmacology
Antipsychotics: Drug Interactions - questions and answers-Decreased antipsychotic effects w/
amphetamines
Increased sedation, decreased levels, hypotension w/ barbiturates, BZAs, narcotics
Decreased levels w/ smoking
Decreased effectiveness w/ hypoglycemics
Decreased antiparkinson effects w/ levodopa, increases psychosis

Atypical Antipsychotics: MOA - questions and answers-Blocks D2 receptors to decrease DA
Blocks 5HT2 receptors causing reuptake of DA into mesolimbic pathway

Atypical Antipsychotics: Side Effects - questions and answers-Metabolic
EPS
Sedation
Galactorrhea
CNS s/s
Hypersalivation- clozapine
Myocarditis- clozapine
QT prolongation- paliperdione, zispradone, iloperidone
NMS

Benzodiazepines (BZAs): Drug Interactions - questions and answers-Increased sedation with
CNS depressants, MAOIs, TCAs
Increased BZA levels w/ disulfiram, cimetidine
Increased phenytoin levels
Decreased effectiveness w/ antacids
Decreased NM blockage w/ succinylcholine

Benzodiazepines (BZAs): MOA - questions and answers-Binds to BZA receptors at GABAa
ligand-gated Cl channel to enhance inhibitory effects of GABA in amygdala-centered fear
circuits
Boosts Cl

Benzodiazepines (BZAs): Pregnancy & Lactation - questions and answers-Floppy infant
syndrome

Benzodiazepines (BZAs): Side Effects - questions and answers-Amnesia
Ataxia, motor incoordination
Confusion, impaired cognition
Depression
Drowsiness, dizziness, lightheadedness
Dysarthria




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PMHNP_ Pharmacology questions and answers.pdf###############################################################

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PMHNP_ PharmacologyPharmacology
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answers.pdf###############################################################
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Headache
Weight gain
Sexual dysfunction

Monoamine Oxidase Inhibitors (MAOIs): Drug Interactions - questions and answers-Increased
SS w/ SSRIs
Increased CV risk w/ sympathomimetics
Increased CNS depression with CNS depressants, anesthetics
Increased hypotension w/ antihypertensives
Increased ACH response
Multiple food interactions

Monoamine Oxidase Inhibitors (MAOIs): MOA - questions and answers-Inhibit monoamine
oxidase to prevent breakdown of NE, 5HT, and DA to increase and restore levels

Monoamine Oxidase Inhibitors (MAOIs): Side Effects - questions and answers-CSN
hyperstimulation
Hypotension
ACH effects
Hematologic, hepatic dysfunction

Mood Stabilizers: MOA - questions and answers-Blocks voltage-sensitive Na channels
Increases GABA

Mood Stabilizers: Pregnancy & Lactation - questions and answers-VPA- neural tube
Lithium- Ebstein anomaly

Mood Stabilizers: Side Effects - questions and answers-Tremor
Lethargy
Malaise
Anorexia
N/V/D
Edema
Abdominal pain
CNS s/s
Weight gain
Hair loss
Impaired thyroid function
VPA- hepatotoxicity, pancreatitis, thrombocytopenia, DRESS
Lithium- nephrotoxicity, CVD

Non-Stimulant: Drug Interactions - questions and answers-2D6 inh (SSRIs, Wellbutrin)
increases levels




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