NSG530-Exam,./2,./Wilkes
1. Autoimmunity:,./reaction,./of,./immune,./response,./to,./one's,./own,./tissues
2. Tolerance:,./self-antigens,./not,./normally,./seen,./by,./the,./immune,./system
3. Most,./common,./autoimmune,./disease:,./Systemic,./lupus,./erythematosus,./(SLE)
4. Type, . / 1, . / DM,, . / MS,, . / RA:, . / notable,./autoimmune,./diseases
5. SLE:,./chronic,./autoimmune,./inflammatory,./disease,./that,./attects,./many,./body,./systems-,./more,./women,./then,./men
6. Clinical, . / Manifestations, . / of, . / SLE:, . / -,./arthralgias,./or,./arthritis
- vasculitis,./and,./rash
- renal,./disease
- hematologic, . / changes,, . / especially, . / anemia
- cardiovascular,. / disease
7. SLE, . / Positive, . / Labs:, . / ANA,./screen
8. Alloimmunity:,./Immune,./reaction,./to,./tissues,./of,./another,./individual
9. x3,./alloimmunity,./reactions:,./transfusion,./reactions,,./transplant,./reactions,,./fetus,./during,./pregnancy
10. Alloantigens:, . / nonself,./antigens,./from,./members,./of,./the,./same,./species
11. transfusion,./reaction:,./a,./serious,,./and,./potentially,./fatal,,./complication,./of,./a,./blood,./transfusion,./in,./w
hich,./a,./severe,./immune,./response,./occurs,./because,./the,./patient's,./blood,./and,./the,./donated,./blood,./do,./not,./mat
ch
12. universal,./donor:,./Type,./O,./blood
13. universal,./recipient:,./type,./AB,./blood
14. Type, . / A, . / blood, . / has, . / antibodies, . / in, . / the, . / blood, . / plasma.:, . / B,./antibodies
15. Rh,./blood,./type:,./Presence,./or,./absence,./of,./Rh,./factor,./(antigen,./D),./on,./erythrocytes,./determines,./if,./blood,./ty
pe,./is,./positive,./or,./negative
16. Hemolitic,./disease,./of,./the,./newborn:,./Rh,./-,./mothers,,./Rh,./+,./fetuses
17. Rhogram:, . / antigen,./D,./immunoglobulin-
Rh,./incompatibility,./(necessary,./for,./Rh,./negative,./mothers,./who,./give,./birth,./to,./an,./Rh,./positive,./baby;,./prevents,./he
molytic,./disease,./of,./the,./newborn)
18. D,./antigen,./expressed,./on,./RBC:,./Rh,./blood,./group
19. Transpant,./rejection:,./MHCs,./are,./a,./major,./target
20. Transplant,./Reaction,./Classifications:,./hyperacute,,./acute,,./chronic
21. transplant, . / reaction, . / that, . / is, . / immediate, . / and, . / rare-
, . / what, . / happens, . / to, . / tissue?:, . / -
hyperacute,,./instant,,./graft,./turns,./white,./instead,./of,./pink
, NSG530-Exam,./2,./Wilkes
22. transplant,./reactions-
,./ acute,./ and,./ chronic,./ are,./ what,./ type,./ of,./ reactions?:, . / type,./IV,./(4)
23. HTN,./and,./diabetes,./are,./risk,./factors,./for,./which,./transplant,./reactions?:,./chronic
, NSG530-Exam,./2,./Wilkes
24. immune,./deficiency:,./the,./loss,./of,./the,./body's,./ability,./to,./respond,./to,./antigens,./and,./epitopes
25. primary, . / immunodeficiency:, . / congenital;,./usually,./genetic,./errors
26. secondary,./immunodeficiency:,./(acquired),./loss,./of,./immune,./functioning,./as,./a,./result,./of,./an,./illn
ess,./or,./treatment
27. Immune, . / Deficiencies:, . / Congenital,./[Bruton,,./DiGeorge,,./SCID],./and,./acquired,./[HIV/AIDS]
28. DiGeorge,./Syndrome:,./congenital-
,./failure,./3rd/4th,./pharyngeal,./pouches,./to,./develop;,./T,./cell,./deficiency;,./absent,./thymus
29. Bare, . / lymphocyte, . / syndrome:, . / 1.,./Partial,./or,./complete,./deficiency,./in,./MHC,./I,./or,./MHC,./II
2. Patients,./have,./an,./increased,./susceptibility,./to,./viral,./and,./opportunistic,./infections
3. Symptoms:,./range,./from,./none,./to,./severe,./combined
immune,./deficiency,,./depending,./on,./number,./of,./MHC,./expressed
30. Predominantly, . / Antibody, . / Deficiencies:, . / -most,./common,./immune,./deficiency
-defective,./B-cell,./development
31. Hypogammaglobulinemia:,./an,./abnormally,./low,./concentration,./of,./gamma,./globulin,./in,./the,./blood,./a
nd,./increased,./risk,./of,./infection
32. Agammaglobulinemia:, . / disorder,./marked,./by,./an,./almost,./complete,./lack,./of,./immunoglobulins,./or,./
antibod-ies
33. Phagocyte,./defects:,./Inadequate,./numbers,./or,./defects,./in,./function,./of,./phagocytes
34. Chronic, . / Granulomatous, . / Disease, . / (CGD):, . / defect,./in,./NADPH,./oxidase,./’‘susceptibility,./to,./infe
ctions,./with,./catalase,./+,./organisms,./(S.,./aureus,,./Aspergillus,,./etc...)
35. Defects,./in,./Innate,./Immunity:,./-Defect,./in,./capacity,./to,./produce,./immune,./response
-Chronic,./mucocutaneous,./candidiasis
36. Complement, . / deficiencies:, . / repeated, ./ infections,. / of,. / encapsulated,. / pathogens
37. IVIG,./(intravenous,./immunoglobulin):,./Mostly,./*IgG*,./pooled,./from,./donors,./to,./give,./high,./level
s,./of,./protection
Used,. / for:, . / *immunodeficiencies*
38. secondary,./deficiency,./examples:,./pregnancy,,./burns,,./emotional,./trauma,,./eating,./disorders,,./diabete
s,,./sickle,./cell
39. Maligancies:, . / virtually,./all,./are,./complicated,./by,./immunosuppression
40. AIDS,./(acquired,./immune,./deficiency,./syndrome):,./Immune,./system,./disease,./caused,./by,./t
he,./Human,./Immunodeficiency,./Virus,./(HIV),./which,./over,./a,./period,./of,./years,./weakens,./the,./capacity,./of,./the,./i
, NSG530-Exam,./2,./Wilkes
mmune,./system,./to
1. Autoimmunity:,./reaction,./of,./immune,./response,./to,./one's,./own,./tissues
2. Tolerance:,./self-antigens,./not,./normally,./seen,./by,./the,./immune,./system
3. Most,./common,./autoimmune,./disease:,./Systemic,./lupus,./erythematosus,./(SLE)
4. Type, . / 1, . / DM,, . / MS,, . / RA:, . / notable,./autoimmune,./diseases
5. SLE:,./chronic,./autoimmune,./inflammatory,./disease,./that,./attects,./many,./body,./systems-,./more,./women,./then,./men
6. Clinical, . / Manifestations, . / of, . / SLE:, . / -,./arthralgias,./or,./arthritis
- vasculitis,./and,./rash
- renal,./disease
- hematologic, . / changes,, . / especially, . / anemia
- cardiovascular,. / disease
7. SLE, . / Positive, . / Labs:, . / ANA,./screen
8. Alloimmunity:,./Immune,./reaction,./to,./tissues,./of,./another,./individual
9. x3,./alloimmunity,./reactions:,./transfusion,./reactions,,./transplant,./reactions,,./fetus,./during,./pregnancy
10. Alloantigens:, . / nonself,./antigens,./from,./members,./of,./the,./same,./species
11. transfusion,./reaction:,./a,./serious,,./and,./potentially,./fatal,,./complication,./of,./a,./blood,./transfusion,./in,./w
hich,./a,./severe,./immune,./response,./occurs,./because,./the,./patient's,./blood,./and,./the,./donated,./blood,./do,./not,./mat
ch
12. universal,./donor:,./Type,./O,./blood
13. universal,./recipient:,./type,./AB,./blood
14. Type, . / A, . / blood, . / has, . / antibodies, . / in, . / the, . / blood, . / plasma.:, . / B,./antibodies
15. Rh,./blood,./type:,./Presence,./or,./absence,./of,./Rh,./factor,./(antigen,./D),./on,./erythrocytes,./determines,./if,./blood,./ty
pe,./is,./positive,./or,./negative
16. Hemolitic,./disease,./of,./the,./newborn:,./Rh,./-,./mothers,,./Rh,./+,./fetuses
17. Rhogram:, . / antigen,./D,./immunoglobulin-
Rh,./incompatibility,./(necessary,./for,./Rh,./negative,./mothers,./who,./give,./birth,./to,./an,./Rh,./positive,./baby;,./prevents,./he
molytic,./disease,./of,./the,./newborn)
18. D,./antigen,./expressed,./on,./RBC:,./Rh,./blood,./group
19. Transpant,./rejection:,./MHCs,./are,./a,./major,./target
20. Transplant,./Reaction,./Classifications:,./hyperacute,,./acute,,./chronic
21. transplant, . / reaction, . / that, . / is, . / immediate, . / and, . / rare-
, . / what, . / happens, . / to, . / tissue?:, . / -
hyperacute,,./instant,,./graft,./turns,./white,./instead,./of,./pink
, NSG530-Exam,./2,./Wilkes
22. transplant,./reactions-
,./ acute,./ and,./ chronic,./ are,./ what,./ type,./ of,./ reactions?:, . / type,./IV,./(4)
23. HTN,./and,./diabetes,./are,./risk,./factors,./for,./which,./transplant,./reactions?:,./chronic
, NSG530-Exam,./2,./Wilkes
24. immune,./deficiency:,./the,./loss,./of,./the,./body's,./ability,./to,./respond,./to,./antigens,./and,./epitopes
25. primary, . / immunodeficiency:, . / congenital;,./usually,./genetic,./errors
26. secondary,./immunodeficiency:,./(acquired),./loss,./of,./immune,./functioning,./as,./a,./result,./of,./an,./illn
ess,./or,./treatment
27. Immune, . / Deficiencies:, . / Congenital,./[Bruton,,./DiGeorge,,./SCID],./and,./acquired,./[HIV/AIDS]
28. DiGeorge,./Syndrome:,./congenital-
,./failure,./3rd/4th,./pharyngeal,./pouches,./to,./develop;,./T,./cell,./deficiency;,./absent,./thymus
29. Bare, . / lymphocyte, . / syndrome:, . / 1.,./Partial,./or,./complete,./deficiency,./in,./MHC,./I,./or,./MHC,./II
2. Patients,./have,./an,./increased,./susceptibility,./to,./viral,./and,./opportunistic,./infections
3. Symptoms:,./range,./from,./none,./to,./severe,./combined
immune,./deficiency,,./depending,./on,./number,./of,./MHC,./expressed
30. Predominantly, . / Antibody, . / Deficiencies:, . / -most,./common,./immune,./deficiency
-defective,./B-cell,./development
31. Hypogammaglobulinemia:,./an,./abnormally,./low,./concentration,./of,./gamma,./globulin,./in,./the,./blood,./a
nd,./increased,./risk,./of,./infection
32. Agammaglobulinemia:, . / disorder,./marked,./by,./an,./almost,./complete,./lack,./of,./immunoglobulins,./or,./
antibod-ies
33. Phagocyte,./defects:,./Inadequate,./numbers,./or,./defects,./in,./function,./of,./phagocytes
34. Chronic, . / Granulomatous, . / Disease, . / (CGD):, . / defect,./in,./NADPH,./oxidase,./’‘susceptibility,./to,./infe
ctions,./with,./catalase,./+,./organisms,./(S.,./aureus,,./Aspergillus,,./etc...)
35. Defects,./in,./Innate,./Immunity:,./-Defect,./in,./capacity,./to,./produce,./immune,./response
-Chronic,./mucocutaneous,./candidiasis
36. Complement, . / deficiencies:, . / repeated, ./ infections,. / of,. / encapsulated,. / pathogens
37. IVIG,./(intravenous,./immunoglobulin):,./Mostly,./*IgG*,./pooled,./from,./donors,./to,./give,./high,./level
s,./of,./protection
Used,. / for:, . / *immunodeficiencies*
38. secondary,./deficiency,./examples:,./pregnancy,,./burns,,./emotional,./trauma,,./eating,./disorders,,./diabete
s,,./sickle,./cell
39. Maligancies:, . / virtually,./all,./are,./complicated,./by,./immunosuppression
40. AIDS,./(acquired,./immune,./deficiency,./syndrome):,./Immune,./system,./disease,./caused,./by,./t
he,./Human,./Immunodeficiency,./Virus,./(HIV),./which,./over,./a,./period,./of,./years,./weakens,./the,./capacity,./of,./the,./i
, NSG530-Exam,./2,./Wilkes
mmune,./system,./to
