Medical-Surgical Nursing 2026
300 Practice Questions & Answers
15 SETS | 300 ORIGINAL CASE-BASED QUESTIONS
Clinical cues | nursing priorities | concise rationales
, Welcome
Practice clinical judgment with 300 original short-response case questions covering common adult medical-surgical nursing
conditions. Each 20-question set is followed by an answer key and a concise rationale.
Use: Answer each set before turning to the key. Review the clinical cue, priority, or safety principle behind each response.
Questions are educational practice items, not treatment instructions; use current orders, policy, and clinical guidance in patient
care.
Question format: Short-response prompts with answers and rationales; no multiple-choice options.
Independence: Original educational content, not copied from secure exams and not affiliated with or endorsed by Elsevier,
HESI, NCSBN, or any nursing program.
Table of Contents
Set Questions Topic
01 1-20 Cardiovascular: Ischemia, Dysrhythmias and Vascular Care
02 21-40 Respiratory: Obstructive Disease, Infection and Acute Failure
03 41-60 Neurology: Stroke, Seizures and Neuromuscular Care
04 61-80 Endocrine: Diabetes, Thyroid and Adrenal Disorders
05 81-100 Gastrointestinal: Acute Abdomen, Bowel and Nutrition
06 101-120 Renal and Urinary
07 121-140 Fluids, Electrolytes, and Acid-Base
08 141-160 Hematology and Oncology
09 161-180 Musculoskeletal and Connective Tissue
10 181-200 Skin, Wounds, Burns, and Pressure Injury
11 201-220 Infection, Sepsis, and Isolation
12 221-240 Perioperative and Postoperative Med-Surg
13 241-260 Critical Care and Emergency Med-Surg
14 261-280 Medications and Safe Administration in Med-Surg
15 281-300 Dosage, Assessment, and Integrated Clinical Judgment
MED-SURG NURSING 2026 | ORIGINAL PRACTICE WORKBOOK 2
, Set 01 of 15 | Cardiovascular: Ischemia, Dysrhythmias and
Vascular Care
Questions 1-20 | Write a concise response.
1. A patient reports crushing chest pressure radiating to the jaw with diaphoresis. What is the priority?
________________________________________________________________________________
2. A patient with chest pain has ST elevation in contiguous leads. What is the priority goal?
________________________________________________________________________________
3. A patient with suspected MI is prescribed sublingual nitroglycerin and has BP 86/54. What should the nurse do?
________________________________________________________________________________
4. A patient taking nitroglycerin reports taking sildenafil earlier today. What is the concern?
________________________________________________________________________________
5. A patient with chest pain has a 12-lead ECG ordered. When should it be obtained?
________________________________________________________________________________
6. A patient after MI develops new crackles, dyspnea, and falling oxygen saturation. What is the priority?
________________________________________________________________________________
7. A patient with MI is pale, cool, hypotensive, and confused. What complication is likely?
________________________________________________________________________________
8. A patient with atrial fibrillation asks why anticoagulation may be prescribed. What is the purpose?
________________________________________________________________________________
9. A patient taking warfarin has black, tarry stools. What should the nurse advise?
________________________________________________________________________________
10. A patient on digoxin has nausea, yellow vision, and an apical pulse of 52/min. What is the action?
________________________________________________________________________________
11. A postoperative patient has unilateral calf swelling and tenderness. What should the nurse do?
________________________________________________________________________________
12. A patient with suspected DVT suddenly develops pleuritic chest pain and dyspnea. What is the priority?
________________________________________________________________________________
13. A patient receiving heparin has a platelet count fall by more than half. What is concerning?
________________________________________________________________________________
14. A patient with PAD has a cool foot and weak pedal pulse. What assessment is important?
________________________________________________________________________________
15. A patient with chronic venous insufficiency has ankle edema. What intervention may help if prescribed?
________________________________________________________________________________
16. A patient with a new AV fistula reports hand numbness. What should be assessed?
________________________________________________________________________________
17. A patient with an AV fistula has no palpable thrill. What should the nurse do?
________________________________________________________________________________
MED-SURG NURSING 2026 | ORIGINAL PRACTICE WORKBOOK 3
, 18. A patient with sickle-cell disease reports severe pain during a crisis. What care is appropriate?
________________________________________________________________________________
19. A patient with sickle-cell disease has a fever. What instruction is important?
________________________________________________________________________________
20. A patient with iron-deficiency anemia asks how to take oral iron. What teaching is useful?
________________________________________________________________________________
MED-SURG NURSING 2026 | ORIGINAL PRACTICE WORKBOOK 4
300 Practice Questions & Answers
15 SETS | 300 ORIGINAL CASE-BASED QUESTIONS
Clinical cues | nursing priorities | concise rationales
, Welcome
Practice clinical judgment with 300 original short-response case questions covering common adult medical-surgical nursing
conditions. Each 20-question set is followed by an answer key and a concise rationale.
Use: Answer each set before turning to the key. Review the clinical cue, priority, or safety principle behind each response.
Questions are educational practice items, not treatment instructions; use current orders, policy, and clinical guidance in patient
care.
Question format: Short-response prompts with answers and rationales; no multiple-choice options.
Independence: Original educational content, not copied from secure exams and not affiliated with or endorsed by Elsevier,
HESI, NCSBN, or any nursing program.
Table of Contents
Set Questions Topic
01 1-20 Cardiovascular: Ischemia, Dysrhythmias and Vascular Care
02 21-40 Respiratory: Obstructive Disease, Infection and Acute Failure
03 41-60 Neurology: Stroke, Seizures and Neuromuscular Care
04 61-80 Endocrine: Diabetes, Thyroid and Adrenal Disorders
05 81-100 Gastrointestinal: Acute Abdomen, Bowel and Nutrition
06 101-120 Renal and Urinary
07 121-140 Fluids, Electrolytes, and Acid-Base
08 141-160 Hematology and Oncology
09 161-180 Musculoskeletal and Connective Tissue
10 181-200 Skin, Wounds, Burns, and Pressure Injury
11 201-220 Infection, Sepsis, and Isolation
12 221-240 Perioperative and Postoperative Med-Surg
13 241-260 Critical Care and Emergency Med-Surg
14 261-280 Medications and Safe Administration in Med-Surg
15 281-300 Dosage, Assessment, and Integrated Clinical Judgment
MED-SURG NURSING 2026 | ORIGINAL PRACTICE WORKBOOK 2
, Set 01 of 15 | Cardiovascular: Ischemia, Dysrhythmias and
Vascular Care
Questions 1-20 | Write a concise response.
1. A patient reports crushing chest pressure radiating to the jaw with diaphoresis. What is the priority?
________________________________________________________________________________
2. A patient with chest pain has ST elevation in contiguous leads. What is the priority goal?
________________________________________________________________________________
3. A patient with suspected MI is prescribed sublingual nitroglycerin and has BP 86/54. What should the nurse do?
________________________________________________________________________________
4. A patient taking nitroglycerin reports taking sildenafil earlier today. What is the concern?
________________________________________________________________________________
5. A patient with chest pain has a 12-lead ECG ordered. When should it be obtained?
________________________________________________________________________________
6. A patient after MI develops new crackles, dyspnea, and falling oxygen saturation. What is the priority?
________________________________________________________________________________
7. A patient with MI is pale, cool, hypotensive, and confused. What complication is likely?
________________________________________________________________________________
8. A patient with atrial fibrillation asks why anticoagulation may be prescribed. What is the purpose?
________________________________________________________________________________
9. A patient taking warfarin has black, tarry stools. What should the nurse advise?
________________________________________________________________________________
10. A patient on digoxin has nausea, yellow vision, and an apical pulse of 52/min. What is the action?
________________________________________________________________________________
11. A postoperative patient has unilateral calf swelling and tenderness. What should the nurse do?
________________________________________________________________________________
12. A patient with suspected DVT suddenly develops pleuritic chest pain and dyspnea. What is the priority?
________________________________________________________________________________
13. A patient receiving heparin has a platelet count fall by more than half. What is concerning?
________________________________________________________________________________
14. A patient with PAD has a cool foot and weak pedal pulse. What assessment is important?
________________________________________________________________________________
15. A patient with chronic venous insufficiency has ankle edema. What intervention may help if prescribed?
________________________________________________________________________________
16. A patient with a new AV fistula reports hand numbness. What should be assessed?
________________________________________________________________________________
17. A patient with an AV fistula has no palpable thrill. What should the nurse do?
________________________________________________________________________________
MED-SURG NURSING 2026 | ORIGINAL PRACTICE WORKBOOK 3
, 18. A patient with sickle-cell disease reports severe pain during a crisis. What care is appropriate?
________________________________________________________________________________
19. A patient with sickle-cell disease has a fever. What instruction is important?
________________________________________________________________________________
20. A patient with iron-deficiency anemia asks how to take oral iron. What teaching is useful?
________________________________________________________________________________
MED-SURG NURSING 2026 | ORIGINAL PRACTICE WORKBOOK 4
