HESI RN 2026
300-Question Practice Exam
15 SETS | 300 ORIGINAL PRACTICE QUESTIONS
Clinical judgment | nursing priorities | concise rationales
, Welcome
Fifteen sets of 20 original short-response practice questions cover core RN content, prioritization, calculations, and clinical
judgment. Complete each set before reviewing its answer key and concise rationale.
How to use: Answer without the key, mark uncertain items, then review the cue or safety principle in each rationale. Follow
current clinical guidance, orders, facility policy, and scope of practice in patient care.
Content note: Newly written educational practice material, not copied from secure HESI content and not affiliated with or
endorsed by Elsevier.
Table of Contents
Set Questions Topic
01 1-20 Med-Surg I
02 21-40 Pharmacology
03 41-60 Fundamentals & Safety
04 61-80 Leadership & Delegation
05 81-100 Maternity & Newborn
06 101-120 Pediatrics
07 121-140 Psychiatric Nursing
08 141-160 Critical Care & Emergency
09 161-180 Assessment & Diagnostics
10 181-200 Infection Prevention
11 201-220 Dosage Calculations
12 221-240 NGN Clinical Judgment
13 241-260 Gerontology & Integrated Review
14 261-280 Leadership & Delegation II
15 281-300 NGN Clinical Judgment III
HESI RN 2026 | ORIGINAL PRACTICE WORKBOOK 2
, Set 01 of 15 | Med-Surg I
Questions 1-20 | Write a concise response.
1. COPD patient newly somnolent; rising PaCO2
________________________________________________________________________________
2. DKA patient K 3.0 before insulin
________________________________________________________________________________
3. HF patient with pink frothy sputum
________________________________________________________________________________
4. Suspected stroke with facial droop
________________________________________________________________________________
5. Cirrhosis with confusion and asterixis
________________________________________________________________________________
6. Pancreatitis with severe epigastric pain
________________________________________________________________________________
7. GI bleeding with hypotension
________________________________________________________________________________
8. AKI with peaked T waves
________________________________________________________________________________
9. Chest tube with continuous water-seal bubbling
________________________________________________________________________________
10. Cast pain unrelieved by opioid and passive stretch pain
________________________________________________________________________________
11. SIADH with sodium 118 and headache
________________________________________________________________________________
12. COPD exacerbation with new cyanosis
________________________________________________________________________________
13. Bowel obstruction with distention and emesis
________________________________________________________________________________
14. Pneumonia SpO2 86% with increased work of breathing
________________________________________________________________________________
15. New AV fistula with cool numb fingers
________________________________________________________________________________
16. Ulcerative colitis with frequent bloody stool
________________________________________________________________________________
17. Sickle-cell crisis with severe pain
________________________________________________________________________________
HESI RN 2026 | ORIGINAL PRACTICE WORKBOOK 3
, 18. Possible appendicitis asks for heat
________________________________________________________________________________
19. New stoma appears dusky and dry
________________________________________________________________________________
20. Hyperthyroid patient with fever, agitation, tachycardia
________________________________________________________________________________
HESI RN 2026 | ORIGINAL PRACTICE WORKBOOK 4
300-Question Practice Exam
15 SETS | 300 ORIGINAL PRACTICE QUESTIONS
Clinical judgment | nursing priorities | concise rationales
, Welcome
Fifteen sets of 20 original short-response practice questions cover core RN content, prioritization, calculations, and clinical
judgment. Complete each set before reviewing its answer key and concise rationale.
How to use: Answer without the key, mark uncertain items, then review the cue or safety principle in each rationale. Follow
current clinical guidance, orders, facility policy, and scope of practice in patient care.
Content note: Newly written educational practice material, not copied from secure HESI content and not affiliated with or
endorsed by Elsevier.
Table of Contents
Set Questions Topic
01 1-20 Med-Surg I
02 21-40 Pharmacology
03 41-60 Fundamentals & Safety
04 61-80 Leadership & Delegation
05 81-100 Maternity & Newborn
06 101-120 Pediatrics
07 121-140 Psychiatric Nursing
08 141-160 Critical Care & Emergency
09 161-180 Assessment & Diagnostics
10 181-200 Infection Prevention
11 201-220 Dosage Calculations
12 221-240 NGN Clinical Judgment
13 241-260 Gerontology & Integrated Review
14 261-280 Leadership & Delegation II
15 281-300 NGN Clinical Judgment III
HESI RN 2026 | ORIGINAL PRACTICE WORKBOOK 2
, Set 01 of 15 | Med-Surg I
Questions 1-20 | Write a concise response.
1. COPD patient newly somnolent; rising PaCO2
________________________________________________________________________________
2. DKA patient K 3.0 before insulin
________________________________________________________________________________
3. HF patient with pink frothy sputum
________________________________________________________________________________
4. Suspected stroke with facial droop
________________________________________________________________________________
5. Cirrhosis with confusion and asterixis
________________________________________________________________________________
6. Pancreatitis with severe epigastric pain
________________________________________________________________________________
7. GI bleeding with hypotension
________________________________________________________________________________
8. AKI with peaked T waves
________________________________________________________________________________
9. Chest tube with continuous water-seal bubbling
________________________________________________________________________________
10. Cast pain unrelieved by opioid and passive stretch pain
________________________________________________________________________________
11. SIADH with sodium 118 and headache
________________________________________________________________________________
12. COPD exacerbation with new cyanosis
________________________________________________________________________________
13. Bowel obstruction with distention and emesis
________________________________________________________________________________
14. Pneumonia SpO2 86% with increased work of breathing
________________________________________________________________________________
15. New AV fistula with cool numb fingers
________________________________________________________________________________
16. Ulcerative colitis with frequent bloody stool
________________________________________________________________________________
17. Sickle-cell crisis with severe pain
________________________________________________________________________________
HESI RN 2026 | ORIGINAL PRACTICE WORKBOOK 3
, 18. Possible appendicitis asks for heat
________________________________________________________________________________
19. New stoma appears dusky and dry
________________________________________________________________________________
20. Hyperthyroid patient with fever, agitation, tachycardia
________________________________________________________________________________
HESI RN 2026 | ORIGINAL PRACTICE WORKBOOK 4
