NBME 25 ASSESSMENT WITH SOLUTIONS
,
,1
Exam Section 1: Item 1 of 50
National Board of Medical Examiners
Comprehensive Basic Science Self-Assessment
1. A75-year-old man has decreased exercise tolerance and occasional
syncopal episodes related to exertion. Left-heart catheterization discloses
this pressure tracing (Ao -aorta; LV -left ventricle; LA -
left atrium). The most frequently encountered mechanism underlying this
disorder is which of the following?
ЕCG
A) Amyloid deposition
150-
B) Calcification
C) Cystic medial necrosis
D) Pericardial effusion
100-
O E) Septal hypertrophy
Ao
50-
LV
LA
Time
Time-
Correct Answer: B.
The pressure tracing demonstrates a large pressure gradient between the
left ventricle and aorta during systole, which is consistent with the diagnosis
of aortic stenosis. In the setting of aortic stenosis, the left ventricle must
generate higher pressures in order to
, overcome the opening resistance of the stenotic valve. This increased -
correct ans:
2
Exam Section 1: Item 2 of 50
National Board of Medical Examiners
Comprehensive Basic Science Self-Assessment
2. New reagents are being designed to treat graft-versus-host disease in
HLA-unrelated bone marrow transplant recipients. Reagents should be
designed that selectively deplete which of the following donor cells?
A) B lymphocytes
O B) Dendritic cells
C) Macrophages
D) Neutrophils
E) T lymphocytes
Correct Answer: E.
T lymphocytes, which are responsible for the immune attack against the
recipient, should be the target of agents used to treat graft-versus-host
disease (GVHD) in HLA-unrelated bone marrow transplant recipients. Prior to
grafting of allogeneic stem cells in a bone
marrow transplant, recipient native marrow must be completely ablated. It is
then replaced with donor marrow, which recolonizes the marrow cavity.
Successful transplantation results in reconstitution of the immune system
with the donor's i - correct ans:
3
Exam Section 1: Item 3 of 50
National Board of Medical Examiners
Comprehensive Basic Science Self-Assessment
,
,1
Exam Section 1: Item 1 of 50
National Board of Medical Examiners
Comprehensive Basic Science Self-Assessment
1. A75-year-old man has decreased exercise tolerance and occasional
syncopal episodes related to exertion. Left-heart catheterization discloses
this pressure tracing (Ao -aorta; LV -left ventricle; LA -
left atrium). The most frequently encountered mechanism underlying this
disorder is which of the following?
ЕCG
A) Amyloid deposition
150-
B) Calcification
C) Cystic medial necrosis
D) Pericardial effusion
100-
O E) Septal hypertrophy
Ao
50-
LV
LA
Time
Time-
Correct Answer: B.
The pressure tracing demonstrates a large pressure gradient between the
left ventricle and aorta during systole, which is consistent with the diagnosis
of aortic stenosis. In the setting of aortic stenosis, the left ventricle must
generate higher pressures in order to
, overcome the opening resistance of the stenotic valve. This increased -
correct ans:
2
Exam Section 1: Item 2 of 50
National Board of Medical Examiners
Comprehensive Basic Science Self-Assessment
2. New reagents are being designed to treat graft-versus-host disease in
HLA-unrelated bone marrow transplant recipients. Reagents should be
designed that selectively deplete which of the following donor cells?
A) B lymphocytes
O B) Dendritic cells
C) Macrophages
D) Neutrophils
E) T lymphocytes
Correct Answer: E.
T lymphocytes, which are responsible for the immune attack against the
recipient, should be the target of agents used to treat graft-versus-host
disease (GVHD) in HLA-unrelated bone marrow transplant recipients. Prior to
grafting of allogeneic stem cells in a bone
marrow transplant, recipient native marrow must be completely ablated. It is
then replaced with donor marrow, which recolonizes the marrow cavity.
Successful transplantation results in reconstitution of the immune system
with the donor's i - correct ans:
3
Exam Section 1: Item 3 of 50
National Board of Medical Examiners
Comprehensive Basic Science Self-Assessment
