NR 566 Advanced Pharmacology for the care of the family: week 1
antifungal agents Questions with Verified Answers (Correct
Update)
Question 1: Amphotericin B is a antibiotic is it well absorbed in the GI tract?
Answer: polyene no; poorly absorbed. PO therapy won't work. must be given IV! undergoes binding to
sterol-containing membranes of tissues
Question 2: Amphotericin B must be given
Answer: IV
Question 3: Amphotericin B should be used in impairment occurs in all pts
Answer: life threatening infections Renal
Question 4: when it comes to _, kidney damage = total amphotericin dose in tx
Answer: B highly nephrotoxic
Question 5: if Amphotericin B dose > _ g, permanent damage is likely to occur, can be decreased
by infusing 1 L of saline
Answer: 4
Question 6: if plasma creatinine is > , decrease dose
Answer: 3.5
Question 7: high levels of Itraconazole can cause fatal if taking and : monitor levels!
Answer: ventricular dysrhythmias digoxin, cyclosporine
Question 8: if taking Itraconazole with : PT time should be monitored! can be by azoles if taking
Itraconazole with : check blood sugar can be by azoles, causing severe hypoglocemia
Answer: warfarin; increased sulfonylureas; increased
Question 9: itraconazole is a spectrum Azoles are often used as alternatives to _ for most systemic
fungal infections, systemic and superficial mycoses
Answer: broad antifungal Amphotericin B
Page 1
, Question 10: old people have higher risk for , decreasing achlorhydria ability to absorb
antifungal meds.
Answer: (no gastric acid in stomach)
Question 11: Do not take Itraconazole with meds that raise gastric pH: , ,
Answer: antacids, H2 antagonists, PPIs these meds can decrease the absorption of Itraconazole
Question 12: Caspofungin is a often used in form
Answer: echinocandin IV
Question 13: Caspofungin can be used to treat:
-invasive aspergillosis (fungal lung infection)
-systemic infections
-Candidemia
-Candida-related
-peritonitis
- pleural space
- intraabdominal abscesses
Answer: Candida esophagitis infections
Question 14: is approved for empiric tx of neutropenic fever DT fungal infections
Answer: caspofungin
Question 15: adverse effects of Caspofungin: at IV site , , HoTN, N/V/D
Answer: phlebitis fever, chills
Question 16: Caspofungin can cause effects mediated by release like: rash, flushing,
Answer: histamine pruritis
Question 17: other hematologic adverse effects caused by caspofungin are anemia and
impairment, too. can increase liver enzymes and creatinine
Answer: leukopenia hepatic
Question 18: is the first PO antifungal product for tx of infections caused by dermatophytes
Answer: Griseofulvin
Page 2
antifungal agents Questions with Verified Answers (Correct
Update)
Question 1: Amphotericin B is a antibiotic is it well absorbed in the GI tract?
Answer: polyene no; poorly absorbed. PO therapy won't work. must be given IV! undergoes binding to
sterol-containing membranes of tissues
Question 2: Amphotericin B must be given
Answer: IV
Question 3: Amphotericin B should be used in impairment occurs in all pts
Answer: life threatening infections Renal
Question 4: when it comes to _, kidney damage = total amphotericin dose in tx
Answer: B highly nephrotoxic
Question 5: if Amphotericin B dose > _ g, permanent damage is likely to occur, can be decreased
by infusing 1 L of saline
Answer: 4
Question 6: if plasma creatinine is > , decrease dose
Answer: 3.5
Question 7: high levels of Itraconazole can cause fatal if taking and : monitor levels!
Answer: ventricular dysrhythmias digoxin, cyclosporine
Question 8: if taking Itraconazole with : PT time should be monitored! can be by azoles if taking
Itraconazole with : check blood sugar can be by azoles, causing severe hypoglocemia
Answer: warfarin; increased sulfonylureas; increased
Question 9: itraconazole is a spectrum Azoles are often used as alternatives to _ for most systemic
fungal infections, systemic and superficial mycoses
Answer: broad antifungal Amphotericin B
Page 1
, Question 10: old people have higher risk for , decreasing achlorhydria ability to absorb
antifungal meds.
Answer: (no gastric acid in stomach)
Question 11: Do not take Itraconazole with meds that raise gastric pH: , ,
Answer: antacids, H2 antagonists, PPIs these meds can decrease the absorption of Itraconazole
Question 12: Caspofungin is a often used in form
Answer: echinocandin IV
Question 13: Caspofungin can be used to treat:
-invasive aspergillosis (fungal lung infection)
-systemic infections
-Candidemia
-Candida-related
-peritonitis
- pleural space
- intraabdominal abscesses
Answer: Candida esophagitis infections
Question 14: is approved for empiric tx of neutropenic fever DT fungal infections
Answer: caspofungin
Question 15: adverse effects of Caspofungin: at IV site , , HoTN, N/V/D
Answer: phlebitis fever, chills
Question 16: Caspofungin can cause effects mediated by release like: rash, flushing,
Answer: histamine pruritis
Question 17: other hematologic adverse effects caused by caspofungin are anemia and
impairment, too. can increase liver enzymes and creatinine
Answer: leukopenia hepatic
Question 18: is the first PO antifungal product for tx of infections caused by dermatophytes
Answer: Griseofulvin
Page 2
