CPHON EXAMS COMPREHENSIVE QUESTIONS
AND ANSWERS
◉ Tumor Lysis Syndrome.
Answer: 1. Release of ions and metabolites from dying malignant
cells
2. High Phosphorus, Uric Acid, Potassium; Low Calcium
3. Back/abdominal pain, vomiting, diarrhea, effects of hyperkalemia
(HR effects), hypocalcemia (tetany, seizure, cramps)
4. Most common in high grade NHL and ALL
◉ What kind of cell is seen in Hodgkins Lymphoma?.
Answer: Reed-Sternberg Cell
◉ Ewings Sarcoma is most commonly seen in what patient
population?.
Answer: Males of European descent
◉ How much radiation until hair loss?.
Answer: Temporary= 25 Gray; Permanent=55 Gray
◉ RBC Life Span.
,Answer: 120 days
◉ Platelet life span.
Answer: 7-10 days
◉ IgM.
Answer: First antibody to appear in response to antigen exposure
◉ IgA.
Answer: Antibody most commonly found in mucous membranes
◉ IgE.
Answer: Antibody most commonly seen in hypersensitivity reactions
◉ IgG.
Answer: Most prevalent antibody in the body
◉ AFP can be a tumor marker for which cancers?.
Answer: germ cell tumors; liver tumors
◉ 11:22 translocation is most commonly seen with which
diagnosis?.
,Answer: Ewings Sarcoma (EW it's 11:22)
◉ 9:22 translocation (BCR-ABL) is most commonly seen in which
cancer?.
Answer: CML (Also can be seen in AML or ALL)
◉ Nuremberg Code.
Answer: First document written on ethics of human subjects
research
◉ Belmont Report.
Answer: Established federal guidelines for:
1. Respect for persons
2. Beneficence
3. Justice
◉ The Common Rule.
Answer: US federal policy that specifies ethics regulations for human
subjects research, informed consent, and established the role of IRBs
◉ Tocilizumab.
Answer: IL-6 receptor antagonist, used for cytokine release
syndrome
, ◉ ANC Calculation.
Answer: (%neutrophils + %bands) x WBC count
◉ Maximum dose of Vincristine.
Answer: 2 mg
◉ Alkylating Agents.
Answer: 1. Cell-cycle non-specific
2. Causes breaks in DNA strands
3. Includes drugs like platins, busulfan, thiotepa, cyclophosphamide
◉ Antimetabolites.
Answer: 1. Interferes with cells in the S-phase
2. Inhibit DNA and RNA synthesis
3. Includes drugs like 5FU, methotrexate, cytarabine, hydroxyurea
◉ Antitumor Antibiotics.
Answer: 1. Includes drugs like bleomycin (G2 phase), dactinomycin,
anthracyclines (non-specific)
2. Bind with DNA to prevent RNA synthesis
AND ANSWERS
◉ Tumor Lysis Syndrome.
Answer: 1. Release of ions and metabolites from dying malignant
cells
2. High Phosphorus, Uric Acid, Potassium; Low Calcium
3. Back/abdominal pain, vomiting, diarrhea, effects of hyperkalemia
(HR effects), hypocalcemia (tetany, seizure, cramps)
4. Most common in high grade NHL and ALL
◉ What kind of cell is seen in Hodgkins Lymphoma?.
Answer: Reed-Sternberg Cell
◉ Ewings Sarcoma is most commonly seen in what patient
population?.
Answer: Males of European descent
◉ How much radiation until hair loss?.
Answer: Temporary= 25 Gray; Permanent=55 Gray
◉ RBC Life Span.
,Answer: 120 days
◉ Platelet life span.
Answer: 7-10 days
◉ IgM.
Answer: First antibody to appear in response to antigen exposure
◉ IgA.
Answer: Antibody most commonly found in mucous membranes
◉ IgE.
Answer: Antibody most commonly seen in hypersensitivity reactions
◉ IgG.
Answer: Most prevalent antibody in the body
◉ AFP can be a tumor marker for which cancers?.
Answer: germ cell tumors; liver tumors
◉ 11:22 translocation is most commonly seen with which
diagnosis?.
,Answer: Ewings Sarcoma (EW it's 11:22)
◉ 9:22 translocation (BCR-ABL) is most commonly seen in which
cancer?.
Answer: CML (Also can be seen in AML or ALL)
◉ Nuremberg Code.
Answer: First document written on ethics of human subjects
research
◉ Belmont Report.
Answer: Established federal guidelines for:
1. Respect for persons
2. Beneficence
3. Justice
◉ The Common Rule.
Answer: US federal policy that specifies ethics regulations for human
subjects research, informed consent, and established the role of IRBs
◉ Tocilizumab.
Answer: IL-6 receptor antagonist, used for cytokine release
syndrome
, ◉ ANC Calculation.
Answer: (%neutrophils + %bands) x WBC count
◉ Maximum dose of Vincristine.
Answer: 2 mg
◉ Alkylating Agents.
Answer: 1. Cell-cycle non-specific
2. Causes breaks in DNA strands
3. Includes drugs like platins, busulfan, thiotepa, cyclophosphamide
◉ Antimetabolites.
Answer: 1. Interferes with cells in the S-phase
2. Inhibit DNA and RNA synthesis
3. Includes drugs like 5FU, methotrexate, cytarabine, hydroxyurea
◉ Antitumor Antibiotics.
Answer: 1. Includes drugs like bleomycin (G2 phase), dactinomycin,
anthracyclines (non-specific)
2. Bind with DNA to prevent RNA synthesis
