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REx-PN Practice Exam 2026 | 73 Scenario-Based Pharmacology Questions & Verified Answers | Psych, Cardiac & High-Alert Meds | Graded A+

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REX-PN Practice Exam 2026 | Most Tested Questions | Graded A+ 73 scenario-based pharmacology questions with the correct answer marked on every item. Unlike a suffix-and-drug-class drill, this set puts you inside realistic clinical situations — a patient on lithium reporting GI upset, a phenytoin dose increase, a diuretic adherence question — the format REx-PN and NCLEX-PN actually test. Drugs and topics covered: - Psychiatric medications – lithium toxicity recognition, clozapine's recognized side effects, diazepam and liver metabolism, fluoxetine patient education, trazodone's primary use - Cardiac and renal – diuretic adherence teaching for heart failure, warfarin and anticoagulant considerations - Neurological – phenytoin toxicity signs after a dose increase, sumatriptan and migraine treatment follow-up - Endocrine and pediatrics – individualized insulin dosing in children with Type 1 diabetes - Corticosteroids – recognizing 'buffalo hump' and other long-term steroid effects - Geriatric pharmacology principles – dosing approach for clients over 70 Procedure-related medication safety – anticoagulant use before a myelogram, contrast allergy screening Format: 33-page PDF, question-and-answer layout with correct responses highlighted. Note: if you've already purchased our REx-PN Pharmacology 2026 (suffix and drug-class) set, this document covers different specific drugs and clinical scenarios rather than repeating that content. Instant download after purchase.

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REX-PN Practice Exam 2026 | Most Tested Questions |
Graded A+
1. What is the primary use of trazodone in medical treatment?

Depression

Pain relief

Anxiety

Insomnia

2. If a heart failure patient reports feeling less fluid retention after starting
diuretics, what should the nurse advise regarding their medication
adherence?

Stop taking the diuretic immediately.

Reduce the dosage of the diuretic by half.

Continue taking the diuretic as prescribed until advised otherwise.

Switch to a different medication without consulting a doctor.

3. Why is it important to monitor liver function in patients receiving diazepam?

Monitoring liver function is only necessary for long-term diazepam
use.

Diazepam is excreted by the kidneys, so kidney function is more
important.

Diazepam is metabolized in the liver, and impaired liver function
can lead to increased drug levels and toxicity.

Liver function does not affect the metabolism of diazepam.

,4. A patient on lithium presents with increased thirst and gastrointestinal upset.
What should the nurse's immediate action be?

Encourage the patient to drink more fluids without further assessment.

Administer an antiemetic to relieve nausea.

Document the symptoms and wait for the physician's orders.

Assess the patient's lithium levels and monitor for additional
symptoms of toxicity.

5. A nurse is caring for clients over the age of 70. The nurse is aware that when
giving medications to older clients, it is best to use what approach?

Do not stop a medication entirely

Review the drug regimen yearly

Avoid drugs with side effects that impact cognition

Start with the smallest effective dose or increase dose slowly if
needed

6. Describe the significance of the 'buffalo hump' in patients undergoing long-
term corticosteroid therapy.

The 'buffalo hump' is unrelated to medication use and can occur in any
individual.

The 'buffalo hump' indicates fat redistribution often seen in patients
on long-term corticosteroids like prednisone.

The 'buffalo hump' signifies liver dysfunction in patients taking
prednisone.

The 'buffalo hump' is a sign of muscle growth due to increased protein
synthesis.

,7. If a patient takes sumatriptan and does not experience relief after one hour,
what is the most appropriate next step?

Wait for another hour before taking more medication.

Call emergency services.

Consult a healthcare provider for further instructions.

Take another dose of sumatriptan immediately.

8. A patient is started on clozapine for treatment resistant schizophrenia. Which
one of the following is a recognised side effect of clozapine therapy?

Stevens-Johnson syndrome

Diarrhoea

Hypersalivation

Bradycardia

Gingival hyperplasia

9. Describe the significance of understanding the side effects of fluoxetine for
patient education.

Understanding the side effects of fluoxetine is crucial for patient
education as it helps patients manage expectations and recognize
adverse reactions early.

Patients should only be informed about the benefits of fluoxetine, not
the side effects.

The side effects of fluoxetine are not important for patient education.

Fluoxetine has no side effects that need to be communicated to
patients.

, 10. What is the recommended approach for determining insulin dosage in
children with Type I diabetes mellitus?

The dose is fixed for all children

The dose is determined individually

The dose is based on weight alone

The dose is dependent solely on age

11. Describe the significance of recognizing symptoms of lithium toxicity in
nursing care.

Nurses should only monitor lithium levels and not focus on symptoms.

Lithium toxicity symptoms are the same as those of dehydration.

Recognizing symptoms of lithium toxicity is crucial for timely
intervention and preventing serious complications.

Symptoms of lithium toxicity are often mild and do not require
immediate action.

12. A patient presents with vertigo and nausea after a recent increase in their
phenytoin dosage. What should the nurse assess for in relation to the
medication?

The nurse should assess for potential allergic reactions to phenytoin.

The nurse should check for signs of dehydration unrelated to
medication.

The nurse should evaluate the patient's diet for deficiencies.

The nurse should assess for signs of phenytoin toxicity due to the
increased dosage.

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