Nurs 5334 Advanced Pharmacology 2026 Endocrine And Diabetes Pharmacology Insulin And Hormone Drug Guid

NURS 5334 ADVANCED PHARMACOLOGY
2026 ENDOCRINE AND DIABETES
PHARMACOLOGY INSULIN AND HORMONE
DRUG GUIDE
◉ simple occupancy theory
Answer: the intensity of the response to a drug is proportional to the
number of receptors occupied by that drug and a maximal response
will occur when all available receptors have been occupied


◉ modified occupancy theory
Answer: takes into account affinity and intrinsic activity


◉ affinity
Answer: the strength of the attraction between a drug and its
receptor


◉ intrinsic activity
Answer: ability of a drug to activate a receptor upon binding


◉ agonists
Answer: molecules that activate receptors

, - endogenous regulators are considered agonists
- have both affinity & high intrinsic activity
- can make processes go faster or slower


EX: dobutamine mimics norepi @ cardiac receptors


◉ antagonists
Answer: produce their effects by preventing receptor activation by
endogenous regulatory molecules and drugs
- affinity but NO intrinsic activity
- NO effects of their own on receptor function
- if there is no agonist present, antagonist will have no observable
effect


◉ noncompetitive antagonist
Answer: Drug that reduces the effect of an agonist, but does not
compete at the receptor site.
- binds irreversibly to receptors
- reduce maximal response an agonist can elicit (fewer available
receptors)
- impact NOT permanent (cells constantly break down old receptors
& synthesize new ones)