Nu 578, Unit 4 - GI Drugs Questions and Answers
Question 1.
Treatment Goal for PUD/GERD
Correct Answer: •Main treatment goal: neutralization of stomach acid •Oxyntic
glands in stomach secrete acid (parietal cells) •To get maximum acid secretion,
these cells need to be stimulated by gastrin + ACh + histamine “, “ •If any one
of these 3 is acid secretion will be markedly
Question 2.
acid secretion
Correct Answer: ‘ ‘ - ACH gastrin in gut -Histamine is always available in gut ‘ -
when the 3 work together, They stimulate the parietal cells to HCI secretion.
Question 3.
Cimetidine (Tagamet)
Correct Answer: H2 receptor antagonist - PUD or GERD tx - Inhibits P450
enzymes. - Well tolerated, but watch for renal/hepatic tox in older patients.
Question 4.
Ranitidine (Zantac)
Correct Answer: H2 receptor antagonist - PUD or GERD tx -Less P450
inhibition—on recall due to contaminant that may cause cancer
Question 5.
Famotidine (Pepcid)
Correct Answer: H2 receptor antagonist - PUD or GERD tx - No P450 inhibition
Question 6.
Nizatidine (Axid)
Correct Answer: H2 receptor antagonist - PUD or GERD tx - No P450
inhibition—recalled drug
Question 7.
Aluminium salts(Remegel)
Correct Answer: - Antacid - PUD or GERD tx - Constipation, hypercalcemia
Question 8.
Ca carbonate(Tums)
Correct Answer: - Antacid - PUD or GERD tx - Constipation, hypercalcemia
, Question 9.
Mg salts(Milk of Magnesia)
Correct Answer: - Antacid - PUD or GERD tx - diarrhea
Question 10.
Na citrate (Bicitra)
Correct Answer: Prep-op antacid
Question 11.
Sucralfate (Carafate)
Correct Answer: Forms protective coat over ulcer, causes constipation
Question 12.
Metoclopramide (Reglan)
Correct Answer: ‘ - rate of gastric emptying - extrapyramidal effect, possible -
do NOT use w/MAOIs or antipsychotics
Question 13.
Cisapride (Propulsid)
Correct Answer: ‘ ‘ GI motility by ACh release. Used for GERD
Question 14.
Omeprazole (Prilosec) Esomeprazole (Nexium) Lansoprazole (Prevacid) Pantoprazole
(Protonix) Rabeprazole (Aciphex)
Correct Answer: - Inhibits H+ secretion by blocking H+/K+ ATPase. - Also
inhibits P450. - PPIs—Proton Pump Inhibitors. - Linked to chronic kidney disease
with long term use; difficult to deprescribe without a lot of acid reflux
Question 15.
Misoprostol (Cytotec)
Correct Answer: - PG derivative. ‘ - Protects stomach by HCO3 + mucus
secretion. - Do NOT use in pregnancy!
Question 16.
Treatment of Ulcers
Correct Answer: • Ulcers are usually colonized by H pylori which delay the
healing process. Strategies for PUD combine an H2 antagonist or PPI+ an
antacid + an antibiotic • Most H2 blockers have best efficacy if given 30-60 min
before meal • Watch coadministration of other drugs with antacids!
Question 1.
Treatment Goal for PUD/GERD
Correct Answer: •Main treatment goal: neutralization of stomach acid •Oxyntic
glands in stomach secrete acid (parietal cells) •To get maximum acid secretion,
these cells need to be stimulated by gastrin + ACh + histamine “, “ •If any one
of these 3 is acid secretion will be markedly
Question 2.
acid secretion
Correct Answer: ‘ ‘ - ACH gastrin in gut -Histamine is always available in gut ‘ -
when the 3 work together, They stimulate the parietal cells to HCI secretion.
Question 3.
Cimetidine (Tagamet)
Correct Answer: H2 receptor antagonist - PUD or GERD tx - Inhibits P450
enzymes. - Well tolerated, but watch for renal/hepatic tox in older patients.
Question 4.
Ranitidine (Zantac)
Correct Answer: H2 receptor antagonist - PUD or GERD tx -Less P450
inhibition—on recall due to contaminant that may cause cancer
Question 5.
Famotidine (Pepcid)
Correct Answer: H2 receptor antagonist - PUD or GERD tx - No P450 inhibition
Question 6.
Nizatidine (Axid)
Correct Answer: H2 receptor antagonist - PUD or GERD tx - No P450
inhibition—recalled drug
Question 7.
Aluminium salts(Remegel)
Correct Answer: - Antacid - PUD or GERD tx - Constipation, hypercalcemia
Question 8.
Ca carbonate(Tums)
Correct Answer: - Antacid - PUD or GERD tx - Constipation, hypercalcemia
, Question 9.
Mg salts(Milk of Magnesia)
Correct Answer: - Antacid - PUD or GERD tx - diarrhea
Question 10.
Na citrate (Bicitra)
Correct Answer: Prep-op antacid
Question 11.
Sucralfate (Carafate)
Correct Answer: Forms protective coat over ulcer, causes constipation
Question 12.
Metoclopramide (Reglan)
Correct Answer: ‘ - rate of gastric emptying - extrapyramidal effect, possible -
do NOT use w/MAOIs or antipsychotics
Question 13.
Cisapride (Propulsid)
Correct Answer: ‘ ‘ GI motility by ACh release. Used for GERD
Question 14.
Omeprazole (Prilosec) Esomeprazole (Nexium) Lansoprazole (Prevacid) Pantoprazole
(Protonix) Rabeprazole (Aciphex)
Correct Answer: - Inhibits H+ secretion by blocking H+/K+ ATPase. - Also
inhibits P450. - PPIs—Proton Pump Inhibitors. - Linked to chronic kidney disease
with long term use; difficult to deprescribe without a lot of acid reflux
Question 15.
Misoprostol (Cytotec)
Correct Answer: - PG derivative. ‘ - Protects stomach by HCO3 + mucus
secretion. - Do NOT use in pregnancy!
Question 16.
Treatment of Ulcers
Correct Answer: • Ulcers are usually colonized by H pylori which delay the
healing process. Strategies for PUD combine an H2 antagonist or PPI+ an
antacid + an antibiotic • Most H2 blockers have best efficacy if given 30-60 min
before meal • Watch coadministration of other drugs with antacids!
