NU 578 Unit 1--#2 Questions and Answers
Question 1.
Full term
Correct Answer: 36-40 weeks gestation
Question 2.
Ganglionic blocking agents
Correct Answer: Interrupt impulse transmission through ganglia of the
autonomic nervous system. They do this by competing with Ach for binding to
nicotinic receptors in autonomic ganglia.
Question 3.
Generic name
Correct Answer: Assigned by US Adopted Names Council. -each drug has only
ONE -aka nonproprietary name or US Adopted Name
Question 4.
Glomerular filtration
Correct Answer: Moves drugs from the blood into the tubular urine within the
glomerulus of the Bowman's capsule.
Question 5.
Half life
Correct Answer: The time it takes for a drug to be 50% of its original
concentration in the body. The time required for the amount of dug in the body
to decrease by 50%.
Question 6.
Hepatic metabolism
Correct Answer: Is low in newborns.
Question 7.
Hepatic microsomal enzyme system
Correct Answer: a.k.a. P450 system which an enzyme system consisting of 12
closely enzyme families in the liver involved with metabolizing drugs.
Cyochrome P450 is a key component of the system. These enzymes are capable
of catalyzing a wide variety of reactions using drugs as substrate.
Question 8.
, Hepatotoxic drugs
Correct Answer: Drugs that cause injury to the liver. Patients taking these
should have liver function tests to check liver enzymes: aspartate
aminotransferase (AST, formerly known as SGOT) and alanine aminotransferase
(ALT, formerly known as SGPT).
Question 9.
Iatrogenic disease
Correct Answer: A disease produced by drugs.
Question 10.
Idiosyncratic effect
Correct Answer: An uncommon drug response resulting from a genetic
predisposition.
Question 11.
Inactivation
Correct Answer: Drug metabolism can convert pharmacologically active
compounds to inactive forms.
Question 12.
Induction
Correct Answer: The process of stimulating liver enzyme synthesis to increase
the drug-metabolizing capacity of the liver.
Question 13.
Infants
Correct Answer: weeks 5-52
Question 14.
Intramuscular administration
Correct Answer: Absorption pattern: rapidly or slowly depending on the water
solubility of the drug and blood flow to the site
Question 15.
Advantages to IM administration
Correct Answer: Administration of poorly soluble drugs, administration of depot
preparations which absorb slowly.
Question 16.
Barriers to IM administration
Question 1.
Full term
Correct Answer: 36-40 weeks gestation
Question 2.
Ganglionic blocking agents
Correct Answer: Interrupt impulse transmission through ganglia of the
autonomic nervous system. They do this by competing with Ach for binding to
nicotinic receptors in autonomic ganglia.
Question 3.
Generic name
Correct Answer: Assigned by US Adopted Names Council. -each drug has only
ONE -aka nonproprietary name or US Adopted Name
Question 4.
Glomerular filtration
Correct Answer: Moves drugs from the blood into the tubular urine within the
glomerulus of the Bowman's capsule.
Question 5.
Half life
Correct Answer: The time it takes for a drug to be 50% of its original
concentration in the body. The time required for the amount of dug in the body
to decrease by 50%.
Question 6.
Hepatic metabolism
Correct Answer: Is low in newborns.
Question 7.
Hepatic microsomal enzyme system
Correct Answer: a.k.a. P450 system which an enzyme system consisting of 12
closely enzyme families in the liver involved with metabolizing drugs.
Cyochrome P450 is a key component of the system. These enzymes are capable
of catalyzing a wide variety of reactions using drugs as substrate.
Question 8.
, Hepatotoxic drugs
Correct Answer: Drugs that cause injury to the liver. Patients taking these
should have liver function tests to check liver enzymes: aspartate
aminotransferase (AST, formerly known as SGOT) and alanine aminotransferase
(ALT, formerly known as SGPT).
Question 9.
Iatrogenic disease
Correct Answer: A disease produced by drugs.
Question 10.
Idiosyncratic effect
Correct Answer: An uncommon drug response resulting from a genetic
predisposition.
Question 11.
Inactivation
Correct Answer: Drug metabolism can convert pharmacologically active
compounds to inactive forms.
Question 12.
Induction
Correct Answer: The process of stimulating liver enzyme synthesis to increase
the drug-metabolizing capacity of the liver.
Question 13.
Infants
Correct Answer: weeks 5-52
Question 14.
Intramuscular administration
Correct Answer: Absorption pattern: rapidly or slowly depending on the water
solubility of the drug and blood flow to the site
Question 15.
Advantages to IM administration
Correct Answer: Administration of poorly soluble drugs, administration of depot
preparations which absorb slowly.
Question 16.
Barriers to IM administration
